Rubber processing oil based on modified epoxidized vegetable oils (m-EVO) was prepared by a reaction of epoxidized palm oil EPO) or epoxidized soybean oil (ESBO) with N-Phenyl-ρ-phenylenediamine (PPD) at a mole ratio of 1:0.5. The comparison of m-EVO with aromatic oil (Treated distillate aromatic extract, TDAE) on extrusion process behaviors (output rate, extrusion rate, screw efficiency, heat generation, die swell, extrudate appearance) of carbon black (N330) filled natural rubber (NR) compound was made. It was found that the mooney viscosity of m-EVO based natural rubber compounds are slightly higher than that of the TDAE based natural rubber compound (ML(1+4)100°C: m-ESBO 65.5±0.7; m-EPO 59.7±0.2; TDAE 56.5±1.0), which probably due to the poorer filler dispersion in the compounds. The extrusion process behaviors for output rate (g/min: m-ESBO 191.0±0.6; m-EPO 191.2±0.4; TDAE 195.5±0.6), extrusion rate (cm3/min: m-ESBO 179.6±0.6; m-EPO 183.2±0.4; TDAE 186.4±0.6) and screw efficiency (%: m-ESBO 30.8±0.6; m-EPO 31.4±0.4; TDAE 32.0±0.6). All the three compounds show similar extrusion process behaviors in which the TDAE based compounds shows a marginal higher values than the m-EVO as its lower mooney viscosity lead to a better flow. The m-EPO and m-ESBO based natural rubber compounds show very similar extrusion process behaviors. The heat generation (°C: m-ESBO 61.0±0.8; m-EPO 62.1±0.4; TDAE 63.1±1.0) and die swell (%: m-ESBO 11.0±0.7; m-EPO 11.0±0.5; TDAE 12.7±0.3) of the m-EVO based natural rubber compounds are slightly lower than those of the TDAE based natural rubber compound. As there are no significant differences in the extrusion process behaviors, with respect to extrusion process, m-EVO can be used to replace TDAE oil.