scholarly journals Effect of minodronic acid (ONO-5920) on bone mineral density and arthritis in adult rats with collagen-induced arthritis

2003 ◽  
Vol 48 (6) ◽  
pp. 1732-1741 ◽  
Author(s):  
Itsuro Yamane ◽  
Hiroshi Hagino ◽  
Toru Okano ◽  
Makoto Enokida ◽  
Daisuke Yamasaki ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Collagen Induced Arthritis ◽  
Adult Rats ◽  
Minodronic Acid

Comparative effects of cyclosporine, tacrolimus and rapamycine on bone remodelling and bone mineral density of healthy adult rats

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S244
Author(s):  
M. Rubert ◽  
M. Montero ◽  
M. Diaz-Curiel ◽  
M. Soldevilla ◽  
C. De la Piedra
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Healthy Adult ◽  
Bone Remodelling ◽  
Mineral Density ◽  
Adult Rats

IGF-I and pamidronate increase bone mineral density in ovariectomized adult rats

1993 ◽  
Vol 265 (5) ◽  
pp. E770-E776 ◽  
Author(s):  
P. Ammann ◽  
R. Rizzoli ◽  
K. Muller ◽  
D. Slosman ◽  
J. P. Bonjour
Keyword(s):  
Bone Mineral Density ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Mineral Density ◽  
Adult Rats ◽  
Igf I ◽  
Midshaft Tibia ◽  
Dose Dependent Increase ◽  
Dose Dependent ◽  
Ovariectomized Adult Rats

Effects induced by insulin-like growth factor I (IGF-I) and/or the bisphosphonate pamidronate (APD) on bone mineral density (BMD) of the lumbar spine and proximal and midshaft tibia were studied in adult rats made osteopenic by ovariectomy, using dual-energy X-ray absorptiometry. IGF-I, which was administered by osmotic minipumps implanted subcutaneously for 6 wk, caused a dose-dependent increase of BMD at the three investigated sites. A 4-wk course of IGF-I, followed by intermittent cyclical APD administration, induced significant increases of BMD at the levels of spine and proximal tibia. At midshaft tibia, where cortical bone predominates, BMD was increased by IGF-I only. In conclusion, IGF-I increased BMD at sites with trabecular and/or cortical bone, whereas the APD influence was mainly detectable in the former site only.

scholarly journals Effect of Raloxifene on Arthritis and Bone Mineral Density in Rats with Collagen-Induced Arthritis

2010 ◽  
Vol 88 (2) ◽  
pp. 87-95 ◽  
Author(s):  
Ikuta Hayashi ◽  
Hiroshi Hagino ◽  
Toru Okano ◽  
Makoto Enokida ◽  
Ryota Teshima
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Collagen Induced Arthritis
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