Corrigendum for: Levels of folate receptor autoantibodies in maternal and cord blood and risk of neural tube defects in a Chinese population, 106:685-695 (10.1002/bdra.23517)

2016 ◽  
Vol 106 (12) ◽  
pp. 1062-1062
Author(s):  
Na Yang ◽  
Linlin Wang ◽  
Richard H. Finnell ◽  
Zhiwen Li ◽  
Lei Jin ◽  
...  
Keyword(s):  
Cord Blood ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population ◽  
Folate Receptor

scholarly journals Levels of folate receptor autoantibodies in maternal and cord blood and risk of neural tube defects in a Chinese population

2016 ◽  
Vol 106 (8) ◽  
pp. 685-695 ◽  
Author(s):  
Na Yang ◽  
Linlin Wang ◽  
Richard H. Finnell ◽  
Zhiwen Li ◽  
Lei Jin ◽  
...  
Keyword(s):  
Cord Blood ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population ◽  
Folate Receptor

scholarly journals Levels of PAH–DNA adducts in cord blood and cord tissue and the risk of fetal neural tube defects in a Chinese population

2015 ◽  
Vol 46 ◽  
pp. 73-78 ◽  
Author(s):  
Deqing Yi ◽  
Yue Yuan ◽  
Lei Jin ◽  
Guodong Zhou ◽  
Huiping Zhu ◽  
...  
Keyword(s):  
Cord Blood ◽  
Dna Adducts ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population

Association betweenPTCH1polymorphisms and risk of neural tube defects in a Chinese population

2013 ◽  
Vol 97 (6) ◽  
pp. 409-415 ◽  
Author(s):  
Zhen Wang ◽  
Li Wang ◽  
Shaofang Shangguan ◽  
Xiaolin Lu ◽  
Shaoyan Chang ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population

scholarly journals The GLI2 Missense Variant rs3738880 Significantly Increases the Risk of Neural Tube Defects in the Han Chinese Population

2017 ◽  
Vol 1 (3) ◽  
pp. 127 ◽  
Author(s):  
Xue-Yan Yang ◽  
Shu-Xia Chen ◽  
Hui-Li Li ◽  
Cai-Hua Li ◽  
Ting Zhang ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population ◽  
Missense Variant ◽  
Han Chinese ◽  
Han Chinese Population

scholarly journals Vitamin B-12 and liver activity and expression of methionine synthase are decreased in fetuses with neural tube defects

2019 ◽  
Vol 109 (3) ◽  
pp. 674-683
Author(s):  
Ma'atem B Fofou-Caillierez ◽  
Rosa-Maria Guéant-Rodriguez ◽  
Jean-Marc Alberto ◽  
Céline Chéry ◽  
Thomas Josse ◽  
...  
Keyword(s):  
Cord Blood ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Intrinsic Factor ◽  
Methionine Synthase ◽  
Vitamin B ◽  
Transcriptional Level ◽  
Gene Variant ◽  
Methionine Synthase Reductase ◽  
Vitamin B 12

ABSTRACT Background The risk of neural tube defects (NTDs) is influenced by nutritional factors and genetic determinants of one-carbon metabolism. A key pathway of this metabolism is the vitamin B-12– and folate-dependent remethylation of homocysteine, which depends on methionine synthase (MS, encoded by MTR), methionine synthase reductase, and methylenetetrahydrofolate reductase. Methionine, the product of this pathway, is the direct precursor of S-adenosylmethionine (SAM), the universal methyl donor needed for epigenetic mechanisms. Objectives This study aimed to evaluate whether the availability of vitamin B-12 and folate and the expression or activity of the target enzymes of the remethylation pathway are involved in NTD risk. Methods We studied folate and vitamin B-12 concentrations and activity, expression, and gene variants of the 3 enzymes in liver from 14 NTD and 16 non-NTD fetuses. We replicated the main findings in cord blood from pregnancies of 41 NTD fetuses compared with 21 fetuses with polymalformations (metabolic and genetic findings) and 375 control pregnancies (genetic findings). Results The tissue concentration of vitamin B-12 (P = 0.003), but not folate, and the activity (P = 0.001), transcriptional level (P = 0.016), and protein expression (P = 0.003) of MS were decreased and the truncated inactive isoforms of MS were increased in NTD livers. SAM was significantly correlated with MS activity and vitamin B-12. A gene variant in exon 1 of GIF (Gastric Intrinsic Factor gene) was associated with a dramatic decrease of liver vitamin B-12 in 2 cases. We confirmed the decreased vitamin B-12 in cord blood from NTD pregnancies. A gene variant of GIF exon 3 was associated with NTD risk. Conclusions The decreased vitamin B-12 in liver and cord blood and decreased expression and activity of MS in liver point out the impaired remethylation pathway as hallmarks associated with NTD risk. We suggest evaluating vitamin B-12 in the nutritional recommendations for prevention of NTD risk beside folate fortification or supplementation.

scholarly journals Levels of PAH–DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population

2013 ◽  
Vol 37 ◽  
pp. 70-75 ◽  
Author(s):  
Yue Yuan ◽  
Lei Jin ◽  
Linlin Wang ◽  
Zhiwen Li ◽  
Le Zhang ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population ◽  
Placental Tissue

scholarly journals Lack of Association between Folate-Receptor Autoantibodies and Neural-Tube Defects

2009 ◽  
Vol 361 (2) ◽  
pp. 152-160 ◽  
Author(s):  
Anne M. Molloy ◽  
Edward V. Quadros ◽  
Jeffrey M. Sequeira ◽  
James F. Troendle ◽  
John M. Scott ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Folate Receptor

Reduced folate carrier gene is a risk factor for neural tube defects in a Chinese population

2005 ◽  
Vol 73 (6) ◽  
pp. 430-433 ◽  
Author(s):  
Lijun Pei ◽  
Huiping Zhu ◽  
Aiguo Ren ◽  
Zhiwen Li ◽  
Ling Hao ◽  
...  
Keyword(s):  
Risk Factor ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population ◽  
Reduced Folate Carrier

scholarly journals The Maternal ITPK1 Gene Polymorphism Is Associated with Neural Tube Defects in a High-Risk Chinese Population

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86145 ◽  
Author(s):  
Zhen Guan ◽  
Jianhua Wang ◽  
Jin Guo ◽  
Fang Wang ◽  
Xiuwei Wang ◽  
...  
Keyword(s):  
High Risk ◽  
Gene Polymorphism ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population

scholarly journals Lack of Association Between Folate-Receptor Autoantibodies and Neural-Tube Defects

2009 ◽  
Vol 64 (11) ◽  
pp. 716-718
Author(s):  
Anne M. Molloy ◽  
Edward V. Quadros ◽  
Jeffrey M. Sequeira ◽  
James F. Troendle ◽  
John M. Scott ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Folate Receptor
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