Reproductive and Developmental Toxicity of Orally Administered Botanical Composition, UP446-Part III: Effects on Fertility and Early Embryonic Development to Implantation in Sprague Dawley Rats

2015 ◽  
Vol 104 (4) ◽  
pp. 166-176 ◽  
Author(s):  
Mesfin Yimam ◽  
Young-Chul Lee ◽  
Eu-Jin Hyun ◽  
Qi Jia
Keyword(s):  
Embryonic Development ◽  
Developmental Toxicity ◽  
Early Embryonic Development ◽  
Botanical Composition ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Fertility and early embryonic development toxicity assessment of naringin in Sprague-Dawley rats

2021 ◽  
Vol 123 ◽  
pp. 104938
Author(s):  
Yonggang Wang ◽  
Hao Wu ◽  
Pan Chen ◽  
Weiwei Su ◽  
Wei Peng ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Toxicity Assessment ◽  
Early Embryonic Development ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Toxicity effects of a novel potent triple reuptake inhibitor, LPM570065, on the fertility and early embryonic development in Sprague-Dawley rats

2018 ◽  
Vol 100 ◽  
pp. 45-51 ◽  
Author(s):  
Wei Guo ◽  
Yonglin Gao ◽  
Wanglin Jiang ◽  
Chunmei Li ◽  
Fei Lin ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Reuptake Inhibitor ◽  
Early Embryonic Development ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Toxicity Effects

Safety Assessment of a Hydroethanolic Extract of Caralluma fimbriata

2013 ◽  
Vol 32 (5) ◽  
pp. 385-394 ◽  
Author(s):  
Antoinette Y. Odendaal ◽  
Narendra S. Deshmukh ◽  
Tennille K. Marx ◽  
Alexander G. Schauss ◽  
John R. Endres ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Toxicity Study ◽  
Developmental Study ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Toxicological Assessment ◽  
Sprague Dawley Rats ◽  
Chromosomal Aberration Test ◽  
Hydroethanolic Extract

This toxicological assessment evaluated the safety of a hydroethanolic extract prepared from Caralluma fimbriata (CFE), a dietary supplement marketed worldwide as an appetite suppressant. Studies included 2 in vitro genotoxicity assays, a repeated dose oral toxicity study, and a developmental study in rats. No evidence of in vitro mutagenicity or clastogenicity surfaced in the in vitro studies at concentrations up to 5000 μg of extract/plate (Ames test) or 5000 μg of extract/mL (chromosomal aberration test). No deaths or treatment-related toxicity were seen in the 6-month chronic oral toxicity study in Sprague-Dawley rats conducted at 3 doses (100, 300, and 1000 mg/kg body weight (bw)/d). The no observed effect level for CFE in this study was considered to be 1000 mg/kg bw/d. A prenatal developmental toxicity study conducted at 3 doses (250, 500, and 1000 mg/kg bw/d) in female Sprague-Dawley rats resulted in no treatment-related external, visceral, or skeletal fetal abnormalities, and no treatment-related maternal or pregnancy alterations were seen at and up to the maximum dose tested. CFE was not associated with any toxicity or adverse events.

Developmental toxicity evaluation of ELF magnetic fields in Sprague–Dawley rats

2003 ◽  
Vol 24 (4) ◽  
pp. 231-240 ◽  
Author(s):  
Moon-Koo Chung ◽  
Jong-Choon Kim ◽  
Sung-Ho Myung ◽  
Dong-Il Lee
Keyword(s):  
Magnetic Fields ◽  
Developmental Toxicity ◽  
Sprague Dawley ◽  
Toxicity Evaluation ◽  
Sprague Dawley Rats

Corrigendum to “Prenatal developmental toxicity study of strontium citrate in Sprague Dawley rats” [Regul. Toxicol. Pharmacol. 101 (2019), 196–200]

2019 ◽  
Vol 106 ◽  
pp. 369
Author(s):  
Chen-Yuan Chiu ◽  
Hsien-Chun Chiu ◽  
Shing-Hwa Liu ◽  
Kuo-Cheng Lan
Keyword(s):  
Developmental Toxicity ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Reproductive and developmental toxicity assessment of palbociclib, a CDK4/6 inhibitor, in Sprague-Dawley rats and New Zealand White rabbits

2019 ◽  
Vol 88 ◽  
pp. 76-84 ◽  
Author(s):  
N.R. Catlin ◽  
C.J. Bowman ◽  
S.M. Engel ◽  
A. Sacaan ◽  
S. Thibault ◽  
...  
Keyword(s):  
New Zealand ◽  
Developmental Toxicity ◽  
Toxicity Assessment ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
New Zealand White Rabbits

Acute and developmental toxicity assessment of erincine A-enriched Hericium erinaceus mycelia in Sprague–Dawley rats

2018 ◽  
Vol 41 (4) ◽  
pp. 459-464 ◽  
Author(s):  
I-Chen Li ◽  
Wan-Ping Chen ◽  
Yen-Po Chen ◽  
Li-Ya Lee ◽  
Yueh-Ting Tsai ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Toxicity Assessment ◽  
Sprague Dawley ◽  
Hericium Erinaceus ◽  
Sprague Dawley Rats

Evaluation of potential reproductive and developmental toxicity of potassium perfluorohexanesulfonate in Sprague Dawley rats

2009 ◽  
Vol 27 (3-4) ◽  
pp. 331-341 ◽  
Author(s):  
John L. Butenhoff ◽  
Shu-Ching Chang ◽  
David J. Ehresman ◽  
Raymond G. York
Keyword(s):  
Developmental Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats
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