Reproductive and Developmental Toxicity of Orally Administered Botanical Composition, UP446-Part II: Effects on Prenatal and Postnatal Development, Including Maternal Function in Sprague-Dawley Rats

2015 ◽  
Vol 104 (4) ◽  
pp. 153-165 ◽  
Author(s):  
Mesfin Yimam ◽  
Young-Chul Lee ◽  
Eu-Jin Hyun ◽  
Qi Jia
Keyword(s):  
Postnatal Development ◽  
Developmental Toxicity ◽  
Botanical Composition ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Maternal Function ◽  
Prenatal And Postnatal Development

scholarly journals REPRODUCTIVE STUDY II : PRENATAL AND POSTNATAL DEVELOPMENT STUDY WITH CANDOXATRIL IN SPRAGUE-DAWLEY RATS

1998 ◽  
Vol 23 (SupplementV) ◽  
pp. 671-679
Author(s):  
Masao HORIMOTO ◽  
Rieko ITO ◽  
Yuji ISOBE ◽  
Masanori SAKIMURA ◽  
Masakatsu TACHIBANA
Keyword(s):  
Postnatal Development ◽  
Sprague Dawley ◽  
Development Study ◽  
Sprague Dawley Rats ◽  
Prenatal And Postnatal Development ◽  
Reproductive Study

Safety Assessment of a Hydroethanolic Extract of Caralluma fimbriata

2013 ◽  
Vol 32 (5) ◽  
pp. 385-394 ◽  
Author(s):  
Antoinette Y. Odendaal ◽  
Narendra S. Deshmukh ◽  
Tennille K. Marx ◽  
Alexander G. Schauss ◽  
John R. Endres ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Toxicity Study ◽  
Developmental Study ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Toxicological Assessment ◽  
Sprague Dawley Rats ◽  
Chromosomal Aberration Test ◽  
Hydroethanolic Extract

This toxicological assessment evaluated the safety of a hydroethanolic extract prepared from Caralluma fimbriata (CFE), a dietary supplement marketed worldwide as an appetite suppressant. Studies included 2 in vitro genotoxicity assays, a repeated dose oral toxicity study, and a developmental study in rats. No evidence of in vitro mutagenicity or clastogenicity surfaced in the in vitro studies at concentrations up to 5000 μg of extract/plate (Ames test) or 5000 μg of extract/mL (chromosomal aberration test). No deaths or treatment-related toxicity were seen in the 6-month chronic oral toxicity study in Sprague-Dawley rats conducted at 3 doses (100, 300, and 1000 mg/kg body weight (bw)/d). The no observed effect level for CFE in this study was considered to be 1000 mg/kg bw/d. A prenatal developmental toxicity study conducted at 3 doses (250, 500, and 1000 mg/kg bw/d) in female Sprague-Dawley rats resulted in no treatment-related external, visceral, or skeletal fetal abnormalities, and no treatment-related maternal or pregnancy alterations were seen at and up to the maximum dose tested. CFE was not associated with any toxicity or adverse events.

Developmental toxicity evaluation of ELF magnetic fields in Sprague–Dawley rats

2003 ◽  
Vol 24 (4) ◽  
pp. 231-240 ◽  
Author(s):  
Moon-Koo Chung ◽  
Jong-Choon Kim ◽  
Sung-Ho Myung ◽  
Dong-Il Lee
Keyword(s):  
Magnetic Fields ◽  
Developmental Toxicity ◽  
Sprague Dawley ◽  
Toxicity Evaluation ◽  
Sprague Dawley Rats

Role of thyroxine on postnatal development of ileal active bile salt transport

1986 ◽  
Vol 251 (2) ◽  
pp. G237-G242 ◽  
Author(s):  
J. E. Heubi
Keyword(s):  
Thyroid Hormone ◽  
Postnatal Development ◽  
Active Transport ◽  
Salt Transport ◽  
Maximal Velocity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Taurocholate Transport

The role of thyroid hormone on the postnatal development of ileal active taurocholate transport uptake was measured by an in vitro incubation technique in Sprague-Dawley rats. In 16-day-old rats treated with pharmacological doses of L-thyroxine (50 micrograms X 100 g body wt-1 X day-1 on days 10-13), ileal active transport appeared precociously whose Km was 1.60 +/- 0.48 mM and Vapp (apparent maximal velocity) was 8.09 +/- 1.14 nmol X min-1 X mg dry wt-1, while age-matched shams had only passive diffusion of taurocholate. To determine whether enhanced endogenous secretion of thyroxine was capable of stimulating development of ileal active taurocholate transport, thyrotrophic stimulating hormone (TSH) (0.5 U/100 g body wt twice daily) was given on days 10-13, with uptake measured on day 16. Following TSH treatment, only passive transport for taurocholate was observed in the ileum; uptake rates were consistently higher than those for untreated controls at each study concentration. Thyroidectomy performed at age 14 days with uptake measured at age 21 days did not ablate development of ileal active transport but resulted in a significant reduction (P less than 0.001) in the Vapp (7.39 +/- 1.10 nmol X min-1 X mg dry wt-1) and a significant increase (P less than 0.014) in Km (1.72 +/- 0.53 mM) compared with age-matched controls. Thyroid hormone does not appear to be obligatory for the postnatal development of ileal active taurocholate transport.

Corrigendum to “Prenatal developmental toxicity study of strontium citrate in Sprague Dawley rats” [Regul. Toxicol. Pharmacol. 101 (2019), 196–200]

2019 ◽  
Vol 106 ◽  
pp. 369
Author(s):  
Chen-Yuan Chiu ◽  
Hsien-Chun Chiu ◽  
Shing-Hwa Liu ◽  
Kuo-Cheng Lan
Keyword(s):  
Developmental Toxicity ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Sprague Dawley Rats
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