The hypotriglyceridemic effect of biotin supplementation involves increased levels of cGMP and AMPK activation

BioFactors ◽  
2012 ◽  
Vol 38 (5) ◽  
pp. 387-394 ◽  
Author(s):  
Asdrúbal Aguilera-Méndez ◽  
Cristina Fernández-Mejía
Keyword(s):  
Ampk Activation ◽  
Hypotriglyceridemic Effect ◽  
Biotin Supplementation

Effects of Biotin Supplementation in the Diet on Adipose Tissue cGMP Concentrations, AMPK Activation, Lipolysis, and Serum-Free Fatty Acid Levels

2015 ◽  
Vol 18 (10) ◽  
pp. 1150-1156 ◽  
Author(s):  
Daniel Boone-Villa ◽  
Asdrubal Aguilera-Méndez ◽  
Adriana Miranda-Cervantes ◽  
Cristina Fernandez-Mejia
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Ampk Activation ◽  
Serum Free Fatty Acid ◽  
Serum Free ◽  
Biotin Supplementation

Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia

2019 ◽  
Vol 476 (24) ◽  
pp. 3687-3704 ◽  
Author(s):  
Aphrodite T. Choumessi ◽  
Manuel Johanns ◽  
Claire Beaufay ◽  
Marie-France Herent ◽  
Vincent Stroobant ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Human Cancer ◽  
Glucose Production ◽  
Liver Mitochondria ◽  
New Drugs ◽  
Structural Isomer ◽  
Rat Liver Mitochondria ◽  
Ionization Mass ◽  
Ampk Activation ◽  
Starting Point

Root extracts of a Cameroon medicinal plant, Dorstenia psilurus, were purified by screening for AMP-activated protein kinase (AMPK) activation in incubated mouse embryo fibroblasts (MEFs). Two isoprenylated flavones that activated AMPK were isolated. Compound 1 was identified as artelasticin by high-resolution electrospray ionization mass spectrometry and 2D-NMR while its structural isomer, compound 2, was isolated for the first time and differed only by the position of one double bond on one isoprenyl substituent. Treatment of MEFs with purified compound 1 or compound 2 led to rapid and robust AMPK activation at low micromolar concentrations and increased the intracellular AMP:ATP ratio. In oxygen consumption experiments on isolated rat liver mitochondria, compound 1 and compound 2 inhibited complex II of the electron transport chain and in freeze–thawed mitochondria succinate dehydrogenase was inhibited. In incubated rat skeletal muscles, both compounds activated AMPK and stimulated glucose uptake. Moreover, these effects were lost in muscles pre-incubated with AMPK inhibitor SBI-0206965, suggesting AMPK dependency. Incubation of mouse hepatocytes with compound 1 or compound 2 led to AMPK activation, but glucose production was decreased in hepatocytes from both wild-type and AMPKβ1−/− mice, suggesting that this effect was not AMPK-dependent. However, when administered intraperitoneally to high-fat diet-induced insulin-resistant mice, compound 1 and compound 2 had blood glucose-lowering effects. In addition, compound 1 and compound 2 reduced the viability of several human cancer cells in culture. The flavonoids we have identified could be a starting point for the development of new drugs to treat type 2 diabetes.

Abstract #1064 Biotin Supplementation Mimicking Graves’ Disease

2018 ◽  
Vol 24 ◽  
pp. 252
Author(s):  
Matthew Gorris ◽  
Brittany Henderson
Keyword(s):  
Graves Disease ◽  
Biotin Supplementation

Abstract #1098 A Curious Case of Persistently Elevated TSH Associated with High Dose Over the Counter Biotin Supplementation

2018 ◽  
Vol 24 ◽  
pp. 271-272
Author(s):  
Thomas Varghese ◽  
Faisal Qureshi
Keyword(s):  
High Dose ◽  
Over The Counter ◽  
Biotin Supplementation

Physiological role for Angptl4/fiaf in exercise-induced muscle AMPK activation

2013 ◽  
Author(s):  
Min-Seon Kim ◽  
Ghi-Su Kim ◽  
Hyuckki Chang ◽  
Mi-Seon Shin ◽  
Hyun Kyong Kim
Keyword(s):  
Physiological Role ◽  
Ampk Activation ◽  
Exercise Induced

AMPK Activation by Ozone Therapy Inhibits Tissue Factor-Triggered Intestinal Ischemia and Ameliorates Chemotherapeutic Enteritis

2019 ◽  
Author(s):  
Qingqing Yu ◽  
Chen Zhang ◽  
Xing Yang ◽  
Xiaotao Zhang ◽  
Chaoyu Wang ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Intestinal Ischemia ◽  
Ampk Activation ◽  
Ozone Therapy

Indirubin-3′-Oxime (IDR3O) Inhibits Proliferation of Osteosarcoma Cells in vitro and Tumor Growth in vivo Through AMPK-Activation and PGC-1α/TFAM Up-Regulation

2020 ◽  
Vol 495 (1) ◽  
pp. 354-360
Author(s):  
Bing Fu ◽  
Guorui Yin ◽  
Ke Song ◽  
Xiurui Mu ◽  
Bo Xu ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Ampk Activation ◽  
Osteosarcoma Cells
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