scholarly journals Process Development for Cross‐flow Diafiltration‐based VLP Disassembly: A Novel High‐throughput Screening Approach

2021 ◽  
Author(s):  
Nils Hillebrandt ◽  
Philipp Vormittag ◽  
Annabelle Dietrich ◽  
Christina H. Wegner ◽  
Jürgen Hubbuch
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Process Development ◽  
Cross Flow ◽  
Screening Approach

A Cell-based High-throughput Screening Approach for the Discovery of New Inhibitors of the Influenza H5N1 Virus

2008 ◽  
Vol 78 (2) ◽  
pp. A48
Author(s):  
William Severson ◽  
Joseph Maddry ◽  
Xi Chen ◽  
Subramaniam Ananthan ◽  
Adrian Poffenberger ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
H5n1 Virus ◽  
Screening Approach ◽  
A Cell ◽  
Influenza H5n1

scholarly journals Identification of novel small molecule inhibitors of adenovirus gene transfer using a high throughput screening approach

2013 ◽  
Vol 170 (1) ◽  
pp. 132-140 ◽  
Author(s):  
Margaret R. Duffy ◽  
Alan L. Parker ◽  
Eric R. Kalkman ◽  
Katie White ◽  
Dmytro Kovalskyy ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Small Molecule ◽  
High Throughput ◽  
High Throughput Screening ◽  
Small Molecule Inhibitors ◽  
Screening Approach

scholarly journals Identification of hepcidin antagonists through a high throughput screening approach

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Eileen Fung ◽  
Jason Hsu ◽  
Robert Damoiseaux ◽  
Tomas Ganz ◽  
Elizabeta Nemeth
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Screening Approach

scholarly journals High-Throughput Screening Approach for Nanoporous Materials Genome Using Topological Data Analysis: Application to Zeolites

2018 ◽  
Vol 14 (8) ◽  
pp. 4427-4437 ◽  
Author(s):  
Yongjin Lee ◽  
Senja D. Barthel ◽  
Paweł Dłotko ◽  
Seyed Mohamad Moosavi ◽  
Kathryn Hess ◽  
...  
Keyword(s):  
Data Analysis ◽  
High Throughput ◽  
High Throughput Screening ◽  
Nanoporous Materials ◽  
Topological Data Analysis ◽  
Screening Approach ◽  
Analysis Application ◽  
Materials Genome ◽  
Topological Data

The Discovery of Novel Protein Tyrosine Phosphatase ε Inhibitors Using a High-throughput Screening Approach

2017 ◽  
Vol 38 (1) ◽  
pp. 44-53 ◽  
Author(s):  
Hye-Yeoung Yun ◽  
Bonsu Ku ◽  
Hye Seon Lee ◽  
Ho-Chul Shin ◽  
Jun-Beom Park ◽  
...  
Keyword(s):  
High Throughput ◽  
Protein Tyrosine Phosphatase ◽  
High Throughput Screening ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine ◽  
Screening Approach ◽  
Novel Protein

scholarly journals A High-Throughput Screening Approach for the Optoelectronic Properties of Conjugated Polymers

2018 ◽  
Author(s):  
Liam Wilbraham ◽  
Enrico Berardo ◽  
Lukas Turcani ◽  
Kim Jelfs ◽  
Martijn Zwijnenburg
Keyword(s):  
Conjugated Polymers ◽  
Electronic Properties ◽  
High Throughput ◽  
High Throughput Screening ◽  
Density Functional ◽  
Tight Binding ◽  
Computational Cost ◽  
Quality Data ◽  
Minor Variation ◽  
Screening Approach

<p>We propose a general high-throughput virtual screening approach for the optical and electronic properties of conjugated polymers. This approach makes use of the recently developed xTB family of low-computational-cost density functional tight-binding methods from Grimme and co-workers, calibrated here to (TD-)DFT data computed for a representative diverse set of (co-)polymers. Parameters drawn from the resulting calibration using a linear model can then be applied to the xTB derived results for new polymers, thus generating near DFT-quality data with orders of magnitude reduction in computational cost. As a result, after an initial computational investment for calibration, this approach can be used to quickly and accurately screen on the order of thousands of polymers for target applications. We also demonstrate that the (opto)electronic properties of the conjugated polymers show only a very minor variation when considering different conformers and that the results of high-throughput screening are therefore expected to be relatively insensitive with respect to the conformer search methodology applied.</p>

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