Dynamic Microfluidic Bioreactor ‐ Hip simulator (DMBH) system for Implant Toxicity Monitoring

2021 ◽  
Author(s):  
Ravindra V. Badhe ◽  
Divya Bijukumar ◽  
Pedro Mesquita ◽  
Kai Yuan Cheng ◽  
Remya Ampadi Ramachandran ◽  
...  
Keyword(s):  
Toxicity Monitoring ◽  
Hip Simulator

Telomere Length and Arsenic: Improving Animal Models of Toxicity by Choosing Mice With Shorter Telomeres

2021 ◽  
Vol 40 (3) ◽  
pp. 211-217
Author(s):  
Brayden Whitlock
Keyword(s):  
Animal Models ◽  
Telomere Length ◽  
Mouse Models ◽  
Arsenic Exposure ◽  
Tumor Formation ◽  
The Body ◽  
Cancer Resistance ◽  
Selective Pressures ◽  
Toxicity Monitoring ◽  
In Captivity

Arsenic is both a chemotherapeutic drug and an environmental toxicant that affects hundreds of millions of people each year. Arsenic exposure in drinking water has been called the worst poisoning in human history. How arsenic is handled in the body is frequently studied using rodent models to investigate how arsenic both causes and treats disease. These models, used in a variety of arsenic-related testing, from tumor formation to drug toxicity monitoring, have virtually always been developed from animals with telomeres that are unnaturally long, likely because of accidental artificial selective pressures. Mice that have been bred in captivity in laboratory conditions, often for over 100 years, are the standard in creating animal models for this research. Using these mice introduces challenges to any work that can be affected by the length of telomeres and the related capacities for tissue repair and cancer resistance. However, arsenic research is particularly susceptible to the misuse of such animal models due to the multiple and various interactions between arsenic and telomeres. Researchers in the field commonly find mouse models and humans behaving very differently upon exposure to acute and chronic arsenic, including drug therapies which seem safe in mice but are toxic in humans. Here, some complexities and apparent contradictions of the arsenic carcinogenicity and toxicity research are reconciled by an explanatory model that involves telomere length explained by the evolutionary pressures in laboratory mice. A low-risk hypothesis is proposed which has the power to determine whether researchers can easily develop more powerful and accurate mouse models by simply avoiding mouse lineages that are very old and have strangely long telomeres. Swapping in newer mouse lineages for the older, long-telomere mice may vastly improve our ability to research arsenic toxicity with virtually no increase in cost or difficulty of research.

Simple isolation method for the bulk isolation of wear particles from metal on metal bearing surfaces generated in a hip simulator test

2012 ◽  
Vol 23 (4) ◽  
pp. 891-901 ◽  
Author(s):  
Fang Lu ◽  
Matt Royle ◽  
Ferdinand V. Lali ◽  
Alister J. Hart ◽  
Simon Collins ◽  
...  
Keyword(s):  
Wear Particles ◽  
Isolation Method ◽  
Hip Simulator ◽  
Metal On Metal ◽  
Simulator Test

A pilot study: dose adaptation of capecitabine using mobile phone toxicity monitoring — supporting patients in their homes

2014 ◽  
Vol 22 (10) ◽  
pp. 2677-2685 ◽  
Author(s):  
Andrew Weaver ◽  
Sharon B. Love ◽  
Mark Larsen ◽  
Milensu Shanyinde ◽  
Rachel Waters ◽  
...  
Keyword(s):  
Pilot Study ◽  
Mobile Phone ◽  
Dose Adaptation ◽  
Toxicity Monitoring ◽  
Study Dose

A hip simulator evaluation of different forms of highly cross-linked polyethylene

1998 ◽  
Vol 31 ◽  
pp. 167 ◽  
Author(s):  
C.R. Bragdon ◽  
D.O. O'Connor ◽  
O.K. Muratoglu ◽  
B. Ramamurti ◽  
M. Jasty ◽  
...  
Keyword(s):  
Hip Simulator

Reducing fretting-initiated crevice corrosion in hip simulator tests using a zirconia-toughened alumina femoral head

2017 ◽  
Vol 106 (8) ◽  
pp. 2815-2826 ◽  
Author(s):  
Masayuki Kyomoto ◽  
Yuichi Shoyama ◽  
Kenichi Saiga ◽  
Toru Moro ◽  
Kazuhiko Ishihara
Keyword(s):  
Femoral Head ◽  
Crevice Corrosion ◽  
Hip Simulator ◽  
Zirconia Toughened Alumina

Hip simulator wear testing according to the newly introduced standard ISO 14242

2005 ◽  
Vol 38 (3) ◽  
pp. 641-642
Author(s):  
V. Saikko ◽  
O. Calonius
Keyword(s):  
Wear Testing ◽  
Hip Simulator

Investigating MoP bearing wear behavior in a hip simulator with muscular properties

2021 ◽  
Vol 10 (1) ◽  
pp. 7-17
Author(s):  
Erkan Bahçe ◽  
Derya Karaman
Keyword(s):  
Wear Behavior ◽  
Hip Simulator

Multiarray Biosensors for Toxicity Monitoring and Bacterial Pathogens

2006 ◽  
pp. 521-538 ◽  
Author(s):  
Jason Karasinski ◽  
Omowunmi Sadik ◽  
Silvana Andreescu
Keyword(s):  
Bacterial Pathogens ◽  
Toxicity Monitoring
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