Trichlorethylene anæsthesia. By GORDON OSTLERE, M.A., M.B., B. Chir. (Camb.), D.A., Deputy First Assistant, Nuffield Department of Anæsthetics, University of Oxford. 4 7/8 × 7 1/4 in. Pp. 83 + viii, with 5 illustrations. 1953. Edinburgh: E. & S. Livingstone Ltd. 7s. 6d.

1953 ◽  
Vol 40 (164) ◽  
pp. 631-631
Keyword(s):  
University Of Oxford ◽  
Nuffield Department

PRODUCTION OF THROMBOXANE B2 BY INTRA-UTERINE TISSUES FROM PREGNANT GOATS IN VITRO

1978 ◽  
Vol 78 (1) ◽  
pp. 159-160 ◽  
Author(s):  
M. D. MITCHELL ◽  
A. P. F. FLINT ◽  
E. J. KINGSTON ◽  
G. D. THORBURN ◽  
J. S. ROBINSON
Keyword(s):  
Thromboxane B2 ◽  
Basic Data ◽  
University Of Oxford ◽  
Obstetrics And Gynaecology ◽  
Nuffield Department ◽  
John Radcliffe Hospital ◽  
Prostaglandin F ◽  
Prostaglandins E

Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU (Received 9 February 1978) It has been shown that prostaglandins play an important role in the mechanism of parturition in many species, including the goat (Currie & Thorburn, 1977; Thorburn, Challis & Robinson, 1977). Recently we have demonstrated that intra-uterine tissues from pregnant goats, when superfused in vitro, produce prostaglandins E and F (PGE, PGF) and 13,14-dihydro-15-oxo-prostaglandin F at various rates (Mitchell, Flint, Robinson & Thorburn, 1978). The exciting discoveries of two potent prostaglandin-like compounds, thromboxane A2 (TXA2; Hamberg, Svensson & Samuelsson, 1975) and prostacyclin (PGI2; Moncada, Gryglewski, Bunting & Vane, 1976), have radically altered our thinking on prostaglandins and basic data are urgently required concerning these compounds. Since prostaglandin endoperoxides are the immediate precursors of both prostaglandins and TXA2 (and PGI2) and since TXA2 has been shown to cause contraction of a number

scholarly journals Immunocytochemical Labelling of Haematological Samples Using Monoclonal Antibodies

Cells ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 127
Author(s):  
Wendy N. Erber
Keyword(s):  
Bone Marrow ◽  
Alkaline Phosphatase ◽  
Monoclonal Antibodies ◽  
University Of Oxford ◽  
Alkaline Phosphatase Staining ◽  
Nuffield Department ◽  
Staining Methods ◽  
Biological Discovery ◽  
The University ◽  
Productive Time

I reflect on my experience working with David Y. Mason in the Leukaemia Research Laboratories in the Nuffield Department of Pathology at the University of Oxford in the early 1980s. This was soon after the first monoclonal antibodies had been produced, which led to an exciting and productive time in biological discovery and pathology diagnostics. A specific focus in the laboratory was the development of immunoenzymatic staining methods that would enable monoclonal antibodies to be applied in diagnostic practice. This paper describes the work that led to the performance of immuno-alkaline phosphatase staining on blood and bone marrow smears, the success of which changed leukaemia diagnosis.

scholarly journals Association of Increased Body Mass Index and Waist to Hip Ratio with Kidney Stone Disease: a prospective analysis of 493,410 UK Biobank participants

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Catherine Lovegrove
Keyword(s):  
Waist Circumference ◽  
Kidney Stones ◽  
Kidney Stone ◽  
Stone Disease ◽  
Uk Biobank ◽  
Kidney Stone Disease ◽  
University Of Oxford ◽  
Increased Risk ◽  
Nuffield Department ◽  
The Uk

Catherine E Lovegrove1,2 – [email protected] Littlejohns3- [email protected] Allen3- [email protected] A Howles1,4- [email protected] W Turney 1,2- [email protected] 1 Department of Urology, Oxford University Hospitals NHS Trust, Oxford, Oxfordshire, UK2 University of Oxford Nuffield Department of Surgical Sciences, Oxford, Oxfordshire, UK3 University of Oxford Nuffield Department of Public Health, Oxford, Oxfordshire, UK4 Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK   Objectives To investigate the relationship between measures of adiposity and risk of incident kidney stone disease. Patients and methods The UK Biobank is a prospective cohort study of ~500,000 participants whose height, weight, BMI, waist circumference, hip circumference, waist:hip ratio (WHR), total fat mass, fat-free mass, body-fat percentage and percentage truncal fat were measured at enrolment with linkage to medical records. ICD-10 and OPCS codes were used to identify individuals with a new diagnosis of nephrolithiasis from 2006-2010. Individuals with a history of kidney stones or incomplete data were excluded. Multivariate Cox-proportional hazard models were used to assess associations between anthropometric measures and incident kidney stones. Results From the UK Biobank, 493,410 individuals were identified for inclusion; 3,466 developed a kidney stone during the study period. Increasing weight, BMI, waist and hip circumferences, WHR, and body and truncal fat were associated with increased risk of incident kidney stone disease. However, after adjustment for BMI, only waist circumference and WHR remained significantly associated with risk of nephrolithiasis. In overweight patients, high (men 94-102cm, women 80-88cm) waist circumference or WHR (men >0.9, women >0.85) conferred >40% increased risk of stone formation. Conclusion This study indicates that android fat distribution is independently associated with increased risk of developing nephrolithiasis. Kidney stone disease is known to be associated with hypertension, cardiovascular disease, and diabetes, all of which are linked to android body shape. Our findings provide insight into anthropometric risk factors for stone disease, will facilitate identification of patients at greatest risk of stone recurrence, and will inform prevention strategies.

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