Early measurement of interstitial fibrosis predicts long-term renal function and graft survival in renal transplantation

1996 ◽  
Vol 83 (8) ◽  
pp. 1082-1085 ◽  
Author(s):  
M. L. Nicholson ◽  
T. A. McCulloch ◽  
S. J. Harper ◽  
T. J. Wheatley ◽  
C. M. Edwards ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Transplantation ◽  
Graft Survival ◽  
Interstitial Fibrosis ◽  
Early Measurement

scholarly journals Preimplantation Biopsy Predicts Delayed Graft Function, Glomerular Filtration Rate and Long-Term Graft Survival of Transplanted Kidneys

2016 ◽  
Vol 2 (1) ◽  
pp. pocj.5000192
Author(s):  
José A. Pedroso ◽  
Konstantinos Giannakakis ◽  
Evaldo Favi ◽  
Maria P. Salerno ◽  
Gionata Spagnoletti ◽  
...  
Keyword(s):  
Renal Function ◽  
Graft Survival ◽  
Patient Survival ◽  
Interstitial Fibrosis ◽  
Graft Function ◽  
Histological Finding ◽  
Delayed Graft Function ◽  
Increased Risk ◽  
Preimplantation Biopsy

Background The predictive value of preimplantation biopsies for long-term graft function is often limited by conflicting results. The aim of this study was to evaluate the influence of time-zero graft biopsy histological scores on early and late graft function, graft survival and patient survival, at different time points. Methods We retrospectively analyzed 284 preimplantation biopsies at a single center, in a cohort of recipients with grafts from live and deceased donors (standard and nonstandard), and their impact in posttransplant renal function after a mean follow-up of 7 years (range 1–16). Implantation biopsy score (IBS), a combination score derived from 4 histopathological aspects, was determined from each sample. The correlation with incidence of delayed graft function (DGF), creatinine clearance (1st, 3rd and 5th posttransplant year) and graft and patient survival at 1 and 5 years were evaluated. Results Preimplantation biopsies provided somewhat of a prognostic index of early function and outcome of the transplanted kidney in the short and long term. In the immediate posttransplantation period, the degree of arteriolosclerosis and interstitial fibrosis correlated better with the presence of DGF. IBS values between 4 and 6 were predictive of worst renal function at 1st and 3rd years posttransplant and 5-year graft survival. The most important histological finding, in effectively transplanted grafts, was the grade of interstitial fibrosis. Patient survival was not influenced by IBS. Conclusions Higher preimplantation biopsy scores predicted an increased risk of early graft losses, especially primary nonfunction. Graft survival (at 1st and 5th years after transplant) but not patient survival was predicted by IBS.

Achievement of Renal Function Recovery and Long-Term Graft Survival After Renal Transplantation.

2014 ◽  
Vol 98 ◽  
pp. 74-75
Author(s):  
S. Wan ◽  
M. Cantarovich ◽  
I. Mucsi ◽  
D. Baran ◽  
S. Paraskevas ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Transplantation ◽  
Graft Survival ◽  
Renal Function Recovery ◽  
Function Recovery

scholarly journals Risk factors for long-term renal survival after renal transplantation: a role for angiotensin-converting enzyme (insertion/deletion) polymorphism?

1998 ◽  
Vol 9 (11) ◽  
pp. 2075-2081 ◽  
Author(s):  
J Broekroelofs ◽  
C A Stegeman ◽  
G Navis ◽  
A M Tegzess ◽  
D De Zeeuw ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Function ◽  
Renal Transplantation ◽  
High Risk ◽  
Graft Survival ◽  
Graft Loss ◽  
Converting Enzyme ◽  
Function Loss

Chronic progressive renal function loss is a main cause of long-term graft loss after initially successful renal transplantation. Transplanted kidneys share some risk factors for renal function loss, such as hypertension or proteinuria, with diseased native kidneys. Recently, it has been shown that renal function loss is influenced by the angiotensin-converting enzyme (ACE) (insertion/deletion [I/D]) genotype in renal disease in diseased native kidneys. This study examines whether donor or recipient ACE (I/D) genotype is a risk factor for graft loss after renal transplantation. To avoid bias by acute events, graft survival was studied, with patients dying with a functioning graft censored, starting at 12 mo after transplantation in a cohort of 367 patients transplanted between 1987 and 1994 with at least 2 yr of follow-up. Mean follow-up was 58 mo. ACE (I/D) genotype was determined by PCR on stored donor and recipient lymphocytes. Neither donor nor recipient ACE (I/D) genotype was associated with graft survival. However, Cox proportional hazards analysis identified recipient, but not donor, ACE (I/D) genotype D-allele to be independently associated with a shorter time to graft loss in subgroups of patients at high risk for graft loss defined by a creatinine clearance <50 ml/min (n = 108, P = 0.017) or proteinuria > or =0.5 g/24 h at 12 mo (n = 97, P = 0.0051) after transplantation. In conclusion, recipient ACE (I/D) genotype was associated with time to graft loss in a specific high-risk subgroup of the study population. This suggests that the effect of ACE (I/D) genotype on graft survival only becomes apparent when other risk factors are simultaneously present.

scholarly journals Inferior long-term graft survival after end-to-side reconstruction for two renal arteries in living donor renal transplantation

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0199629 ◽  
Author(s):  
Shigeyoshi Yamanaga ◽  
Angel Rosario ◽  
Danny Fernandez ◽  
Takaaki Kobayashi ◽  
Mehdi Tavakol ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Graft Survival ◽  
Living Donor ◽  
Renal Arteries

Long-Term Outcomes of Renal Function After Adult Intestinal Transplantation at a Single Small-Volume Center: 2 Cases of Renal Transplantation

2019 ◽  
Vol 51 (5) ◽  
pp. 1525-1530
Author(s):  
Kyung Jai Ko ◽  
Hye Kyung Chang ◽  
Su-Kyung Kwon ◽  
Young Hwa Kim ◽  
Mi-Hyeong Kim ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Transplantation ◽  
Small Volume ◽  
Intestinal Transplantation ◽  
Long Term Outcomes

Use of 12-Month Renal Function and Baseline Clinical Factors to Predict Long-Term Graft Survival

2012 ◽  
Vol 93 (2) ◽  
pp. 172-181 ◽  
Author(s):  
Mark A. Schnitzler ◽  
Krista L. Lentine ◽  
David Axelrod ◽  
Adrian Gheorghian ◽  
Min You ◽  
...  
Keyword(s):  
Renal Function ◽  
Graft Survival ◽  
Clinical Factors

The differences between late graft loss group and long-term graft survival group in renal transplantation

2001 ◽  
Vol 15 ◽  
pp. 16-21 ◽  
Author(s):  
Toshiyuki Tanaka ◽  
Shiro Takahara ◽  
Motoaki Hatori ◽  
Kiyohide Toki ◽  
Jing-Ding Wang ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Graft Survival ◽  
Graft Loss ◽  
Survival Group
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