Authors' reply: Role of transplantation in the management of hepatic malignancy (Br J Surg 2007; 94: 1319–1330)

2008 ◽  
Vol 95 (5) ◽  
pp. 666-667
Author(s):  
S. R. Knight ◽  
P. J. Friend ◽  
P. J. Morris
Keyword(s):  
Hepatic Malignancy

scholarly journals The Role of MicroRNAs in Hepatoblastoma Tumors

Cancers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 409 ◽  
Author(s):  
Ion Cristóbal ◽  
Marta Sanz-Álvarez ◽  
Melani Luque ◽  
Cristina Caramés ◽  
Federico Rojo ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Therapeutic Strategies ◽  
Substantial Contribution ◽  
Hepatic Malignancy ◽  
Recent Advances

Hepatoblastoma is the most common hepatic malignancy during childhood. However, little is still known about the molecular mechanisms that govern the development of this disease. This review is focused on the recent advances regarding the study of microRNAs in hepatoblastoma and their substantial contribution to improv our knowledge of the pathogenesis of this disease. We show here that miRNAs represent valuable tools to identify signaling pathways involved in hepatoblastoma progression as well as useful biomarkers and novel molecular targets to develop alternative therapeutic strategies in this disease.

Primary hepatic malignancy: The role of liver transplantation

1990 ◽  
Vol 77 (9) ◽  
pp. 983-987 ◽  
Author(s):  
T. Ismail ◽  
L. Angrisani ◽  
B. K. Gunson ◽  
S. G. Hübscher ◽  
J. A. C. Buckets ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatic Malignancy

Liver Transplantation for Hepatocellular Carcinoma: An Update

2006 ◽  
Vol 4 (8) ◽  
pp. 762-767 ◽  
Author(s):  
Jean F. Botha ◽  
Alan N. Langnas
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Selection Criteria ◽  
Hepatic Cirrhosis ◽  
The United States ◽  
Treatment Modalities ◽  
Hepatic Malignancy ◽  
The Third ◽  
Small Hcc

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide and the most common primary hepatic malignancy. It arises on a background of hepatic cirrhosis in approximately 95% of the cases in the United States. A wide variety of treatment modalities have been applied in the treatment of HCC. Liver transplantation has emerged as the preferred treatment for patients with small HCC. Transplantation for patients whose tumors do not exceed the Milan criteria yields results equivalent to those of transplantation for non-HCC indications. Controversy now exists regarding the use of living donors, expansion of selection criteria, and role of adjuvant therapy.

Large adrenal tumours mimicking hepatic malignancy: the role of concurrent adrenalectomy and anterior approach hepatectomy

2021 ◽  
Author(s):  
Nitin Agarwal ◽  
Nihar Mohapatra ◽  
Nilesh S. Patil ◽  
Piyush K. Sinha ◽  
Gattu Tharun ◽  
...  
Keyword(s):  
Anterior Approach ◽  
Hepatic Malignancy ◽  
Adrenal Tumours

scholarly journals Role of Perfusion CT Differentiating Hemangiomas from Malignant Hepatic Lesions

2014 ◽  
Vol 4 ◽  
pp. 10 ◽  
Author(s):  
Jagjeet Singh ◽  
Sanjiv Sharma ◽  
Neeti Aggarwal ◽  
R G Sood ◽  
Shikha Sood ◽  
...  
Keyword(s):  
Predictive Value ◽  
Multidetector Ct ◽  
Ct Perfusion ◽  
Mean Transit Time ◽  
Liver Parenchyma ◽  
Study Data ◽  
Perfusion Ct ◽  
Hepatic Malignancy ◽  
Hepatic Lesions

Objective: The purpose of the study was to determine the role of computed tomography (CT) perfusion in differentiating hemangiomas from malignant hepatic lesions. Materials and Methods: This study was approved by the institutional review board. All the patients provided informed consent. CT perfusion was performed with 64 multidetector CT (MDCT) scanner on 45 patients including 27 cases of metastasis, 9 cases of hepatocellular carcinoma (HCC), and 9 cases of hemangiomas. A 14 cm span of the liver was covered during the perfusion study. Data was analyzed to calculate blood flow (BF), blood volume (BV), permeability surface area product (PS), mean transit time (MTT), hepatic arterial fraction (HAF), and induced residue fraction time of onset (IRFTO). CT perfusion parameters at the periphery of lesions and background liver parenchyma were compared. Results: Significant changes were observed in the perfusion parameters at the periphery of different lesions. Of all the perfusion parameters BF, HAF, and IRFTO showed most significant changes. In our study we found: BF of more than 400 ml/100 g/min at the periphery of the hemangiomas showed sensitivity of 88.9%, specificity of 83.3%, positive predictive value (PPV) of 57.1%, and negative predictive value (NPV) of 96.7% in differentiating hemangiomas from hepatic malignancy; HAF of more than 60% at the periphery of hemangiomas showed sensitivity of 77.8%, specificity of 86.1%, PPV of 58.3% and NPV of 93.9% in differentiating hemangiomas from hepatic malignancy; IRFTO of more than 3 s at the periphery of hemangiomas showed sensitivity of 77.8%, specificity of 86.1%, PPV of 58.3%, and NPV of 93.9% in differentiating hemangiomas from hepatic malignancy. Conclusion: Perfusion CT is a helpful tool in differentiating hemangiomas from hepatic malignancy by its ability to determine changes in perfusion parameters of the lesions.

Role of staging laparoscopy in the treatment of hepatic malignancy

1994 ◽  
Vol 167 (1) ◽  
pp. 151-155 ◽  
Author(s):  
Timothy J. Babineau ◽  
W.David Lewis ◽  
Roger L. Jenkins ◽  
Ronald Bleday ◽  
Glenn D. Steele ◽  
...  
Keyword(s):  
Staging Laparoscopy ◽  
Hepatic Malignancy

Role of transplantation in the management of hepatic malignancy

2007 ◽  
Vol 94 (11) ◽  
pp. 1319-1330 ◽  
Author(s):  
S. R. Knight ◽  
P. J. Friend ◽  
P. J. Morris
Keyword(s):  
Hepatic Malignancy

Role of transplantation in the management of hepatic malignancy (Br J Surg 2007; 94: 1319–1330)

2008 ◽  
Vol 95 (5) ◽  
pp. 666-666
Author(s):  
N. Jamieson ◽  
A. Gimson ◽  
R. Freeman
Keyword(s):  
Hepatic Malignancy

Radioembolization for Cholangiocarcinoma

2021 ◽  
Author(s):  
Aamir Ali ◽  
Komal Manzoor ◽  
Jeffrey L. Weinstein ◽  
Salomao Faintuch ◽  
Muneeb Ahmed ◽  
...  
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Systemic Chemotherapy ◽  
Standard Of Care ◽  
Hepatic Malignancy ◽  
Current Standard ◽  
Transarterial Radioembolization ◽  
Total Cancer ◽  
Localized Disease ◽  
Yttrium 90

AbstractCholangiocarcinoma is the second most common primary hepatic malignancy which accounts for 13% of total cancer mortality worldwide. Surgical resection is the only curative treatment for localized disease; however, the majority of patients present when the tumor is unresectable. The incidence of the intrahepatic subtype of cholangiocarcinoma is increasing worldwide. Current standard of care in patients with unresectable intrahepatic cholangiocarcinoma is systemic chemotherapy; however, yttrium-90 transarterial radioembolization (Y90-TARE) is under investigation for the treatment of intrahepatic cholangiocarcinoma with promising trials and published clinical experience. This review critically evaluates the role of Y90-TARE in the management of intrahepatic cholangiocarcinoma.

Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  
Wilms Tumor
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