Classification of and cytoreductive surgery for low-grade appendiceal mucinous neoplasms

2012 ◽  
Vol 99 (7) ◽  
pp. 987-992 ◽  
Author(s):  
J. R. McDonald ◽  
S. T. O'Dwyer ◽  
S. Rout ◽  
B. Chakrabarty ◽  
K. Sikand ◽  
...  
Keyword(s):  
Cytoreductive Surgery ◽  
Low Grade ◽  
Mucinous Neoplasms

Ki67 Does Not Predict Recurrence for Low Grade Appendiceal Mucinous Neoplasms with Peritoneal Dissemination after Cytoreductive Surgery and HIPEC

2021 ◽  
Author(s):  
Erin P. Ward ◽  
Luke Okamuro ◽  
Sohini Khan ◽  
Morgan Hosseini ◽  
Mark A. Valasek ◽  
...  
Keyword(s):  
Cytoreductive Surgery ◽  
Peritoneal Dissemination ◽  
Low Grade ◽  
Mucinous Neoplasms

scholarly journals Low-Grade Appendiceal Mucinous Neoplasm Involving the Endometrium and Presenting with Mucinous Vaginal Discharge

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Vera Vavinskaya ◽  
Joel M. Baumgartner ◽  
Albert Ko ◽  
Cheryl C. Saenz ◽  
Mark A. Valasek
Keyword(s):  
Pseudomyxoma Peritonei ◽  
Vaginal Discharge ◽  
Low Grade ◽  
Invasive Adenocarcinoma ◽  
Peritoneal Disease ◽  
Mucinous Neoplasm ◽  
Mucinous Neoplasms ◽  
Pathological Evaluation ◽  
Classification Management

Primary appendiceal mucinous lesions are uncommon and represent a spectrum from nonneoplastic mucous retention cysts to invasive adenocarcinoma. Low-grade appendiceal mucinous neoplasms (LAMNs) represent an intermediate category on this spectrum and can be classified according to whether or not they are confined to the appendix. Although LAMNs are frequently confined to the appendix, they can also spread to the peritoneum and clinically progress as pseudomyxoma peritonei (i.e., mucinous ascites). Thus, the appropriate classification of appendiceal primary neoplasia is essential for prognosis and influences clinical management. In addition, the precise classification, management, and clinical outcome of patients with disseminated peritoneal disease remain controversial. Here, we report an unusual case of LAMN with pseudomyxoma peritonei that initially presented with mucinous and bloody vaginal discharge. Pathological evaluation revealed low-grade appendiceal mucinous neoplasm with secondary involvement of the peritoneum, ovaries, and endometrial surface. Therefore, LAMN should be considered in the differential diagnosis of mucinous vaginal discharge.

scholarly journals Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for perforated low-grade appendiceal mucinous neoplasms

2020 ◽  
Vol 34 (12) ◽  
pp. 5516-5521 ◽  
Author(s):  
Haytham Abudeeb ◽  
Chelliah R. Selvasekar ◽  
Sarah T. O’Dwyer ◽  
Bipasha Chakrabarty ◽  
Lee Malcolmson ◽  
...  
Keyword(s):  
Intraperitoneal Chemotherapy ◽  
Cytoreductive Surgery ◽  
Hyperthermic Intraperitoneal Chemotherapy ◽  
Operative Time ◽  
Significant Proportion ◽  
Low Grade ◽  
Short Term ◽  
Open Operation ◽  
High Dependency ◽  
Mucinous Neoplasms

Abstract Introduction Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is an established treatment for pseudomyxoma peritonei (PMP) from perforated low-grade appendiceal mucinous neoplasms (LAMN II). In a selected group of LAMN II patients without established PMP, CRS/HIPEC can be performed laparoscopically (L-CRS/HIPEC); however the short-term benefits and safety of this approach have yet to be determined. This study aims to determine the short-term outcomes from a series of L-CRS/HIPEC LAMN II patients compared to those who have undergone a similar open operation (O-CRS/HIPEC) for low-volume PMP. Methods LAMN II patients undergoing L-CRS/HIPEC at a UK national peritoneal tumour centre were compared to O-CRS/HIPEC patients (peritoneal cancer index ≤ 7). Outcomes of interest included Clavien–Dindo complication grade, operative time, blood transfusions, high dependency unit (HDU) admission, length of hospital stay, and histopathological findings. Results 55 L-CRS/HIPEC were compared to 29 O-CRS/HIPEC patients (2003–2017). Groups were matched for age, sex, and procedures. Median operative time was 8.8 (IQR 8.1–9.5) h for L-CRS/HIPEC versus 7.3 (IQR 6.7–8) h for O-CRS/HIPEC (Mann–Whitney test p < 0.001). Post-operative HDU admission was 56% versus 97% (OR 0.04 95% CI 0.01–0.34) and median length of stay = 6 (IQR 5–8) versus 10 (IQR 8–11) days (p < 0.001) for L- versus O-CRS/HIPEC. Despite a normal pre-operative CT scan, 13/55 (23.6%) L-CRS/HIPEC patients had acellular mucin and 2/55 (3.5%) had mucin with epithelium present in their specimens. Residual appendix tumour was identified in 2/55 patients (3.6%). Clavien–Dindo Grade 1–4 complications were similar in both groups with no mortality. Conclusion L-CRS/HIPEC for LAMN II takes longer; however patients have significantly reduced length of HDU and overall stay, without increased post-operative complications. A significant proportion of LAMN II patients undergoing L-CRS/HIPEC have extra-appendiceal acellular mucin with some cases demonstrating residual cellular epithelium from the LAMN II. The risk of these patients developing PMP without surgery is under current review.

Machine Learning Classification of Low-grade and High-grade Chondrosarcomas Based on MRI-based Texture Analysis

2019 ◽  
Author(s):  
S. Gitto ◽  
D. Albano ◽  
V. Chianca ◽  
R. Cuocolo ◽  
L. Ugga ◽  
...  
Keyword(s):  
Machine Learning ◽  
Texture Analysis ◽  
Low Grade ◽  
High Grade ◽  
Machine Learning Classification

Classification of low-grade neuroendocrine tumors of midgut and unknown origin

2002 ◽  
Vol 33 (11) ◽  
pp. 1126-1132 ◽  
Author(s):  
Susanne van Eeden ◽  
Pascal F.H.J. Quaedvlieg ◽  
Babs G. Taal ◽  
G.Johan A. Offerhaus ◽  
Cornelis B.H.W. Lamers ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Unknown Origin ◽  
Low Grade

Necessity of posttreatment surveillance for low‐grade appendiceal mucinous neoplasms

2021 ◽  
Author(s):  
Aakash R. Gupta ◽  
Brian C. Brajcich ◽  
Anthony D. Yang ◽  
David J. Bentrem ◽  
Ryan P. Merkow
Keyword(s):  
Low Grade ◽  
Mucinous Neoplasms
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