Development and validation of a HPLC method for determination of levonorgestrel and quinestrol in rat plasma

2009 ◽  
Vol 24 (7) ◽  
pp. 706-710 ◽  
Author(s):  
Tao Tang ◽  
Pingliang Li ◽  
Laixin Luo ◽  
Dazhao Shi ◽  
Jianqiang Li ◽  
...  
Keyword(s):  
Rat Plasma ◽  
Hplc Method ◽  
Development And Validation

Ecofriendly chromatographic methods for determination of co-prescribed drugs, olanzapine and metformin, in rat plasma

Bioanalysis ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 597-613
Author(s):  
Aml A Emam ◽  
Neven M Habib ◽  
Hamada M Mahmoud ◽  
Nada S Abdelwhab ◽  
Maha M Abdelrahman
Keyword(s):  
Pharmaceutical Preparation ◽  
Rat Plasma ◽  
Reversed Phase ◽  
Hplc Method ◽  
Hypoglycemic Agent ◽  
Chromatographic Methods ◽  
Rp Hplc ◽  
Development And Validation ◽  
Developing System

Background: Olanzapine (OLZ) is one of most recommended drugs for the treatment of schizophrenia while metformin (MET) is the most commonly used hypoglycemic agent. Aim: Development and validation of two green, sensitive and accurate chromatographic methods for the simultaneous determination of OLZ along with the co-prescribed, MET. Materials & methods: TLC-densitometric method with a developing system consisting of methylene chloride:methanol:ethyl acetate:triethylamine (4:4:5:0.1, by volume) and a reversed-phase (RP)-HPLC method where the chromatographic separation was performed using ethanol:water mixture (50: 50, v/v) as a mobile phase. Results: TLC-densitometric method had linearity over concentration ranges of 160–4000 ng/band for OLZ and 150–4500 ng/band for MET, while RP-HPLC method was linear and validated over concentration range of 300–20000 ng/ml for OLZ and MET. Conclusion: Pharmacokinetic study was successfully performed and suggested the possibility of co-administration of MET with OLZ and their further formulation in one pharmaceutical preparation to enhance patient’s compliance.

scholarly journals Development and Validation of a Dual Column HPLC Method for Determination of Albendazole and Its Metabolites in Rat Plasma

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
SUDDHASATTYA DEY ◽  
Sudip Mandal ◽  
Mithun Bhowmick ◽  
Manik Ghosh ◽  
Pankaj Dagur ◽  
...  
Keyword(s):  
Rat Plasma ◽  
Hplc Method ◽  
Dual Column ◽  
Development And Validation

Development and Validation of RP-HPLC Method for Determination of Eprosartan Mesylate in Rat Plasma: Application to Preclinical Pharmacokinetic Study

2015 ◽  
Vol 6 (2) ◽  
pp. 100-104 ◽  
Author(s):  
Pankaj Vijay Dangre ◽  
Shashikanth Nivrutti Dhole
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc ◽  
Development And Validation

Development and validation of a reversed-phase HPLC method for determination of nitrendipine in rat plasma: application to pharmacokinetic studies

2007 ◽  
Vol 21 (4) ◽  
pp. 363-368 ◽  
Author(s):  
Vinay Kumar Venishetty ◽  
Chandrasekar Durairaj ◽  
Ramakrishna Sistla ◽  
Madhusudhan Rao Yamsani ◽  
Prakash V. Diwan
Keyword(s):  
Rat Plasma ◽  
Reversed Phase ◽  
Hplc Method ◽  
Pharmacokinetic Studies ◽  
Reversed Phase Hplc ◽  
Development And Validation

scholarly journals Development and Validation of a New HPLC Method for the Determination of Quetiapine and its Metabolites 7-Hydroxy Quetiapine and Quetiapine Sulfoxide in Rat Plasma

2016 ◽  
Vol 13 (1) ◽  
pp. 10-21 ◽  
Author(s):  
Sakine Atila Karaca ◽  
Işıl Tan Yılmaz ◽  
Erol Şener ◽  
Duygu Yeniceli Uğur
Keyword(s):  
Rat Plasma ◽  
Hplc Method ◽  
Development And Validation

scholarly journals Development and Validation of a HPLC Method for Determination of Isochlorogenic Acid A in Rat Plasma and Application to Pharmacokinetic Study

2017 ◽  
Vol 55 (10) ◽  
pp. 1037-1042 ◽  
Author(s):  
Meifeng Cen ◽  
Heng Liang ◽  
Xiaohong Xiong ◽  
Jie Zeng ◽  
Xuange Cheng ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Development And Validation

Development and Validation of a RP-HPLC Method for Simultaneous Determination of Levofloxacin and Moxifloxacin in Pharmaceutical Dosage Forms

2014 ◽  
Vol 12 (2) ◽  
Author(s):  
Farjahan Nur ◽  
Asma Rahman ◽  
Md. Zakir Sultan ◽  
Md. Gias Uddin ◽  
Mohammad A Rashid
Keyword(s):  
Simultaneous Determination ◽  
Dosage Forms ◽  
Hplc Method ◽  
Pharmaceutical Dosage Forms ◽  
Rp Hplc ◽  
Development And Validation
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