Positive and negative ion chemical ionization mass spectrometry of trimethylsilyl derivatives of pyrrolizidine alkaloids using NH+ and OH− as the reactant ions

1986 ◽  
Vol 13 (6) ◽  
pp. 293-298 ◽  
Author(s):  
H. J. Huizing ◽  
F. De Boer ◽  
H. Hendriks ◽  
W. Balraadjsing ◽  
A. P. Bruins
Keyword(s):  
Mass Spectrometry ◽  
Chemical Ionization ◽  
Pyrrolizidine Alkaloids ◽  
Negative Ion ◽  
Ionization Mass Spectrometry ◽  
Chemical Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Negative Ion Chemical Ionization ◽  
Trimethylsilyl Derivatives ◽  
Derivatives Of

Plasma polyamines determined by negative-ion chemical ionization/mass spectrometry.

1979 ◽  
Vol 25 (9) ◽  
pp. 1564-1571 ◽  
Author(s):  
J R Shipe ◽  
D F Hunt ◽  
J Savory
Keyword(s):  
Mass Spectrometry ◽  
Chemical Ionization ◽  
Negative Ion ◽  
Ionization Mass Spectrometry ◽  
Chemical Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Internal Standards ◽  
Highly Sensitive ◽  
Negative Ion Chemical Ionization ◽  
Derivatives Of

Abstract We have developed an accurate and highly sensitive gas-chromatographic/mass-spectrometric procedure for determining di- and polyamines (putrescine, spermidine, and spermine) in plasma and erythrocytes. Deuterium-labeled analogs of putrescine, spermidine, and spermine were synthesized for use as internal standards. Trifluoroacetyl derivatives of the polyamines were formed during the procedure and then detected with negative-ion chemical ionization/mass spectrometry in combination with multiple ion monitoring. Limits of sensitivity ranged from 0.25 to 1.0 pmol of analyte injected into the instrument.

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