Feasibility of spectral pH measurement during the low‐pH virus inactivation step of continuous therapeutic antibody production

2020 ◽  
Vol 36 (4) ◽  
Author(s):  
Jeffrey D. Goby ◽  
Kenji Furuya ◽  
Eike Zimmermann ◽  
Justin A. Beller ◽  
John M. Schmitt ◽  
...  
Keyword(s):  
Antibody Production ◽  
Low Ph ◽  
Therapeutic Antibody ◽  
Ph Measurement ◽  
Virus Inactivation ◽  
Therapeutic Antibody Production

Current Therapeutic Antibody Production and Process Optimization

2006 ◽  
Vol 5 (4) ◽  
pp. 16-25 ◽  
Author(s):  
Feng Li ◽  
Brian Lee ◽  
Joe Zhou ◽  
Tim Tressel ◽  
Xiaoming Yang
Keyword(s):  
Process Optimization ◽  
Antibody Production ◽  
Therapeutic Antibody ◽  
Therapeutic Antibody Production

Single pass tangential flow filtration to debottleneck downstream processing for therapeutic antibody production

2011 ◽  
Vol 109 (4) ◽  
pp. 962-970 ◽  
Author(s):  
Jemelle Dizon-Maspat ◽  
Justin Bourret ◽  
Anna D'Agostini ◽  
Feng Li
Keyword(s):  
Antibody Production ◽  
Downstream Processing ◽  
Therapeutic Antibody ◽  
Tangential Flow Filtration ◽  
Single Pass ◽  
Tangential Flow ◽  
Flow Filtration ◽  
Therapeutic Antibody Production

scholarly journals A blueprint from nature: miRNome comparison of plasma cells and CHO cells to optimize therapeutic antibody production

2021 ◽  
Author(s):  
Nadja Raab ◽  
Nikolas Zeh ◽  
Patrick Schlossbauer ◽  
Sven Mathias ◽  
Benjamin Lindner ◽  
...  
Keyword(s):  
Antibody Production ◽  
Cho Cells ◽  
Plasma Cells ◽  
Therapeutic Antibody ◽  
Therapeutic Antibody Production

scholarly journals Simplified identification of disulfide, trisulfide, and thioether pairs with 213 nm UVPD

The Analyst ◽  
2018 ◽  
Vol 143 (21) ◽  
pp. 5176-5184 ◽  
Author(s):  
James Bonner ◽  
Lance E. Talbert ◽  
Nicholas Akkawi ◽  
Ryan R. Julian
Keyword(s):  
Clinical Efficacy ◽  
Antibody Production ◽  
Therapeutic Antibody ◽  
Negative Effects ◽  
And Storage ◽  
Therapeutic Antibody Production

Disulfide heterogeneity and other non-native crosslinks introduced during therapeutic antibody production and storage could have considerable negative effects on clinical efficacy, but tracking these modifications remains challenging.

Inactivation of deubiquitinase CYLD enhances therapeutic antibody production in Chinese hamster ovary cells

2018 ◽  
Vol 102 (14) ◽  
pp. 6081-6093 ◽  
Author(s):  
Yafang Lu ◽  
Qin Zhou ◽  
Qianqian Han ◽  
Pengfei Wu ◽  
Lanlan Zhang ◽  
...  
Keyword(s):  
Antibody Production ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Therapeutic Antibody ◽  
Ovary Cells ◽  
Therapeutic Antibody Production

Stable overexpression of mutated PTEN in Chinese hamster ovary cells enhances their performance and therapeutic antibody production

2021 ◽  
pp. 2000623
Author(s):  
Qin Zhou ◽  
Yujie Zhang ◽  
Xiaoxiang Lu ◽  
Chang Wang ◽  
Xinxin Pei ◽  
...  
Keyword(s):  
Antibody Production ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Therapeutic Antibody ◽  
Ovary Cells ◽  
Therapeutic Antibody Production

Continuous Low-pH Virus Inactivation: Challenges and Practical Solutions

2018 ◽  
Vol 38 (15) ◽  
pp. S13-S15
Author(s):  
Mark Schofield ◽  
David Johnson
Keyword(s):  
Low Ph ◽  
Virus Inactivation

Virus Inactivation at Moderately Low pH Varies with Virus and Buffer Properties

2021 ◽  
pp. 2100320
Author(s):  
Pratik U. Joshi ◽  
Christa L. Meingast ◽  
Xuankuo Xu ◽  
Melissa Holstein ◽  
Hasin Feroz ◽  
...  
Keyword(s):  
Low Ph ◽  
Virus Inactivation

scholarly journals Protein A chromatography increases monoclonal antibody aggregation rate during subsequent low pH virus inactivation hold

2015 ◽  
Vol 1415 ◽  
pp. 83-90 ◽  
Author(s):  
Alice R. Mazzer ◽  
Xavier Perraud ◽  
Jennifer Halley ◽  
John O’Hara ◽  
Daniel G. Bracewell
Keyword(s):  
Monoclonal Antibody ◽  
Protein A ◽  
Low Ph ◽  
Virus Inactivation ◽  
Aggregation Rate
Sign in / Sign up

Export Citation Format

Share Document