Comparative evaluation of antioxidant and anti‐inflammatory activity of active compounds identified in Ardisia elliptica extracts from different plant parts

2021 ◽  
Author(s):  
Hathairat Buraphaka ◽  
Watthika Puttha ◽  
Waraporn Putalun
Keyword(s):  
Comparative Evaluation ◽  
Inflammatory Activity ◽  
Active Compounds ◽  
Plant Parts ◽  
Anti Inflammatory ◽  
Ardisia Elliptica

Evaluation of antioxidant, anti-inflammatory activity and identification of active compounds of Humulus scandens

2021 ◽  
Vol 141 ◽  
pp. 126-132
Author(s):  
Dan zhang ◽  
Li-Hong tan ◽  
Yuan-Jiao feng ◽  
Ling yao ◽  
Xue-Wei yan ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Active Compounds ◽  
Anti Inflammatory ◽  
Humulus Scandens

scholarly journals Synthesis of Some 4,5-Dihydrothieno[3,2-e][1,2,4]Triazolo[4,3-a] Pyrimi-dine-2-Carboxamides as Anti-Inflammatory and Analgesic Agents

2013 ◽  
Vol 7 (1) ◽  
pp. 49-65 ◽  
Author(s):  
Omaima G. Shaaban ◽  
Ola H. Rizk ◽  
Aida E. Bayad ◽  
Ibrahim M. El-Ashmawy
Keyword(s):  
Analgesic Activity ◽  
Safety Margin ◽  
Docking Study ◽  
Inflammatory Activity ◽  
Onset Of Action ◽  
Safety Level ◽  
Active Compounds ◽  
Analgesic Agents ◽  
Anti Inflammatory ◽  
Derivatives Of

A new series 4,5-dihydrothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidine-2-carboxamide was synthesized. Twenty one newly synthesized compounds were investigated for their anti-inflammatory and analgesic activity using acute and subacute formalin-induced paw edema models and diclofenac Na as a reference. The acute toxicity (ALD50) and ulcerogenic effects of the active compounds were also determined. The thienotriazolopyrimidines 10a, 10c and 11c were found to exhibit remarkable anti-inflammatory activity at both models in addition to good analgesic activity with a delayed onset of action. Moreover, the active compounds showed high GI safety level and are well tolerated by experimental animals with high safety margin (ALD50 > 0.4 g/kg). Docking study using Molecular Operating Environment (MOE) version 2008.10 into COX-2 has been made for derivatives of highest anti-inflammatory activity.

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