Ultramild Protein-Mediated Click Chemistry Creates Efficient Oligonucleotide Probes for Targeting and Detecting Nucleic Acids

ChemBioChem ◽  
2015 ◽  
Vol 16 (8) ◽  
pp. 1163-1167 ◽  
Author(s):  
Lina J. Nåbo ◽  
Charlotte S. Madsen ◽  
Knud J. Jensen ◽  
Jacob Kongsted ◽  
Kira Astakhova
Keyword(s):  
Nucleic Acids ◽  
Click Chemistry ◽  
Oligonucleotide Probes

Corrigendum: Ultramild Protein-Mediated Click Chemistry Creates Efficient Oligonucleotide Probes for Targeting and Detecting Nucleic Acids

ChemBioChem ◽  
2015 ◽  
Vol 16 (8) ◽  
pp. 1132-1132
Author(s):  
Lina J. Nåbo ◽  
Charlotte S. Madsen ◽  
Knud J. Jensen ◽  
Jacob Kongsted ◽  
Kira Astakhova
Keyword(s):  
Nucleic Acids ◽  
Click Chemistry ◽  
Oligonucleotide Probes

scholarly journals A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids

2021 ◽  
Author(s):  
Nicolò Zuin Fantoni ◽  
Afaf H. El-Sagheer ◽  
Tom Brown
Keyword(s):  
Nucleic Acids ◽  
Click Chemistry

scholarly journals Modified Nucleosides, Nucleotides and Nucleic Acids via Click Azide-Alkyne Cycloaddition for Pharmacological Applications

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3100
Author(s):  
Daniela Perrone ◽  
Elena Marchesi ◽  
Lorenzo Preti ◽  
Maria Luisa Navacchia
Keyword(s):  
Cancer Therapy ◽  
Nucleic Acids ◽  
Click Chemistry ◽  
Nucleoside Analogs ◽  
Modified Nucleosides ◽  
Biological Molecules ◽  
Dipolar Cycloaddition ◽  
Virus Diseases ◽  
Reaction Conditions ◽  
Hybrid Compounds

The click azide = alkyne 1,3-dipolar cycloaddition (click chemistry) has become the approach of choice for bioconjugations in medicinal chemistry, providing facile reaction conditions amenable to both small and biological molecules. Many nucleoside analogs are known for their marked impact in cancer therapy and for the treatment of virus diseases and new targeted oligonucleotides have been developed for different purposes. The click chemistry allowing the tolerated union between units with a wide diversity of functional groups represents a robust means of designing new hybrid compounds with an extraordinary diversity of applications. This review provides an overview of the most recent works related to the use of click chemistry methodology in the field of nucleosides, nucleotides and nucleic acids for pharmacological applications.

scholarly journals Sequence-defined vinyl sulfonamide click nucleic acids (VS-CNAs) and their assembly into dynamically responsive materials

2020 ◽  
Vol 56 (76) ◽  
pp. 11263-11266
Author(s):  
Bryan P. Sutherland ◽  
Paige J. LeValley ◽  
Derek J. Bischoff ◽  
April M. Kloxin ◽  
Christopher J. Kloxin
Keyword(s):  
Nucleic Acids ◽  
Click Chemistry ◽  
Polymer Support ◽  
Soluble Polymer ◽  
Responsive Materials ◽  
Synthetic Strategy ◽  
The Creation

A scalable synthetic strategy was developed towards the creation of sequence-defined DNA analogues employing thiol-Michael click chemistry and a soluble polymer support.

The application of click chemistry for targeting quadruplex nucleic acids

2019 ◽  
Vol 55 (6) ◽  
pp. 731-750 ◽  
Author(s):  
Puja Saha ◽  
Deepanjan Panda ◽  
Jyotirmayee Dash
Keyword(s):  
Nucleic Acids ◽  
Click Chemistry ◽  
Click Reaction ◽  
Dipolar Cycloaddition

The Cu(i)-catalyzed azide and alkyne 1,3-dipolar cycloaddition (CuAAC), commonly known as the “click reaction”, has emerged as a versatile synthetic tool for targeting quadruplex nucleic acids.

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