Interkingdom Responses to Bacterial Quorum Sensing Signals Regulate Frequency and Rate of Nodulation in Legume-Rhizobia Symbiosis

ChemBioChem ◽  
2016 ◽  
Vol 17 (22) ◽  
pp. 2199-2205 ◽  
Author(s):  
Andrew G. Palmer ◽  
Arijit Mukherjee ◽  
Danielle M. Stacy ◽  
Stephen Lazar ◽  
Jean-Michel Ané ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Quorum Sensing Signals

scholarly journals Host modification of a bacterial quorum-sensing signal induces a phenotypic switch in bacterial symbionts

2017 ◽  
Vol 114 (40) ◽  
pp. E8488-E8497 ◽  
Author(s):  
Cleo Pietschke ◽  
Christian Treitz ◽  
Sylvain Forêt ◽  
Annika Schultze ◽  
Sven Künzel ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Bacterial Communities ◽  
Homoserine Lactone ◽  
Innate Immune ◽  
Expression Data ◽  
Phenotypic Switch ◽  
Host Colonization ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Quorum Sensing Signals

Bacterial communities colonize epithelial surfaces of most animals. Several factors, including the innate immune system, mucus composition, and diet, have been identified as determinants of host-associated bacterial communities. Here we show that the early branching metazoan Hydra is able to modify bacterial quorum-sensing signals. We identified a eukaryotic mechanism that enables Hydra to specifically modify long-chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterparts. Expression data revealed that Hydra’s main bacterial colonizer, Curvibacter sp., responds differentially to N-(3-hydroxydodecanoyl)-l-homoserine lactone (3OHC12-HSL) and N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL). Investigating the impacts of the different N-acyl-HSLs on host colonization elucidated that 3OHC12-HSL allows and 3OC12-HSL represses host colonization of Curvibacter sp. These results show that an animal manipulates bacterial quorum-sensing signals and that this modification leads to a phenotypic switch in the bacterial colonizers. This mechanism may enable the host to manipulate the gene expression and thereby the behavior of its bacterial colonizers.

scholarly journals Bacterial Quorum Sensing Signals Self-Assemble in Aqueous Media to Form Micelles and Vesicles: An Integrated Experimental and Molecular Dynamics Study

2020 ◽  
Vol 124 (18) ◽  
pp. 3616-3628
Author(s):  
Curran G. Gahan ◽  
Samarthaben J. Patel ◽  
Michelle E. Boursier ◽  
Kayleigh E. Nyffeler ◽  
James Jennings ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Quorum Sensing ◽  
Aqueous Media ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Quorum Sensing Signals

Inactivation of bacterial quorum sensing signals N-acyl homoserine lactones is widespread in yeasts

2018 ◽  
Vol 122 (1) ◽  
pp. 52-62 ◽  
Author(s):  
Ana Carolina del V. Leguina ◽  
Carolina Nieto ◽  
Hipólito F. Pajot ◽  
Elisa V. Bertini ◽  
Walter Mac Cormack ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Homoserine Lactones ◽  
Acyl Homoserine Lactones ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Quorum Sensing Signals
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