Co‐immobilized Whole Cells with ω‐Transaminase and Ketoreductase Activities for Continuous‐Flow Cascade Reactions

ChemBioChem ◽  
2018 ◽  
Vol 19 (17) ◽  
pp. 1845-1848 ◽  
Author(s):  
László Nagy‐Győr ◽  
Emese Abaházi ◽  
Viktória Bódai ◽  
Péter Sátorhelyi ◽  
Balázs Erdélyi ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Cascade Reactions ◽  
Whole Cells ◽  
Immobilized Whole Cells

scholarly journals Front Cover: Co‐immobilized Whole Cells with ω‐Transaminase and Ketoreductase Activities for Continuous‐Flow Cascade Reactions (ChemBioChem 17/2018)

ChemBioChem ◽  
2018 ◽  
Vol 19 (17) ◽  
pp. 1792-1792
Author(s):  
László Nagy‐Győr ◽  
Emese Abaházi ◽  
Viktória Bódai ◽  
Péter Sátorhelyi ◽  
Balázs Erdélyi ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Cascade Reactions ◽  
Front Cover ◽  
Whole Cells ◽  
Immobilized Whole Cells

Continuous-flow stereoselective reduction of prochiral ketones in a whole cell bioreactor with natural deep eutectic solvents

2021 ◽  
Author(s):  
Francesca Annunziata ◽  
Alessandra Guaglio ◽  
Paola Conti ◽  
Lucia Tamborini ◽  
Raffaella Gandolfi
Keyword(s):  
Continuous Flow ◽  
Flow Reactor ◽  
Deep Eutectic Solvents ◽  
Packed Bed ◽  
Efficient Production ◽  
Stereoselective Reduction ◽  
Whole Cells ◽  
Natural Deep Eutectic Solvents ◽  
Prochiral Ketones ◽  
Immobilized Whole Cells

Immobilized whole cells of Rhodotorula rubra MIM147 were used in a packed bed flow reactor for the enantioselective reduction of β-ketonitriles and for the efficient production of a key building...

Biochemical Energy Conversion by Immobilized Whole Cells.

1983 ◽  
Vol 413 (1 Biochemical E) ◽  
pp. 133-143 ◽  
Author(s):  
SHUICHI SUZUKI ◽  
ISAO KARUBE ◽  
HIDEAKI MATSUOKA ◽  
SATOSHI UEYAMA ◽  
HIROAKI KAWAKUBO ◽  
...  
Keyword(s):  
Energy Conversion ◽  
Whole Cells ◽  
Immobilized Whole Cells

Penicillin G production by immobilized whole cells ofPenicillium chrysogenum

1979 ◽  
Vol 21 (2) ◽  
pp. 261-270 ◽  
Author(s):  
Yasushi Morikawa ◽  
Isao Karube ◽  
Shuichi Suzuki
Keyword(s):  
Penicillin G ◽  
Whole Cells ◽  
Immobilized Whole Cells

scholarly journals Breaking Molecular Symmetry through Biocatalytic Reactions to Gain Access to Valuable Chiral Synthons

Symmetry ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1454
Author(s):  
Angela Patti ◽  
Claudia Sanfilippo
Keyword(s):  
Bioactive Compounds ◽  
Continuous Flow ◽  
Molecular Diversity ◽  
Molecular Symmetry ◽  
Flow Conditions ◽  
Reaction Conditions ◽  
Whole Cells ◽  
Efficient Approach ◽  
Substrate Tolerance ◽  
Gain Access

In this review the recent reports of biocatalytic reactions applied to the desymmetrization of meso-compounds or symmetric prochiral molecules are summarized. The survey of literature from 2015 up to date reveals that lipases are still the most used enzymes for this goal, due to their large substrate tolerance, stability in different reaction conditions and commercial availability. However, a growing interest is focused on the use of other purified enzymes or microbial whole cells to expand the portfolio of exploitable reactions and the molecular diversity of substrates to be transformed. Biocatalyzed desymmetrization is nowadays recognized as a reliable and efficient approach for the preparation of pharmaceuticals or natural bioactive compounds and many processes have been scaled up for multigram preparative purposes, also in continuous-flow conditions.

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