Potential of co-culture of nucleus pulposus mesenchymal stem cells and nucleus pulposus cells in hyperosmotic microenvironment for intervertebral disc regeneration

2013 ◽  
Vol 37 (8) ◽  
pp. 826-834 ◽  
Author(s):  
Yi-Qing Tao ◽  
Cheng-Zhen Liang ◽  
Hao Li ◽  
Yu-Jie Zhang ◽  
Fang-Cai Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Nucleus Pulposus Cells ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration

scholarly journals Generation of human nucleus pulposus cells from stem cells: First steps towards intervertebral disc regeneration.

2016 ◽  
Vol 24 ◽  
pp. S11-S12 ◽  
Author(s):  
P. Colombier ◽  
J. Clouet ◽  
C. Chariau ◽  
C. Chedeville ◽  
J. Lesoeur ◽  
...  
Keyword(s):  
Stem Cells ◽  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Nucleus Pulposus Cells ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration

Transplantation of mesenchymal stem cells and nucleus pulposus cells in a degenerative disc model in rabbits: a comparison of 2 cell types as potential candidates for disc regeneration

2011 ◽  
Vol 14 (3) ◽  
pp. 322-329 ◽  
Author(s):  
Ganjun Feng ◽  
Xianfeng Zhao ◽  
Hao Liu ◽  
Huina Zhang ◽  
Xiangjun Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Nucleus Pulposus ◽  
Disc Degeneration ◽  
Signal Intensity ◽  
Disc Height ◽  
Nucleus Pulposus Cells ◽  
Disc Regeneration ◽  
Disc Model

Object The aim of this study was to compare transplanted mesenchymal stem cells (MSCs) with nucleus pulposus cells (NPCs) in a degenerative disc model in rabbits to determine the better candidate for disc cell therapy. Methods Mesenchymal stem cells and NPCs were transplanted in a rabbit model of disc degeneration. Changes in disc height, according to plain radiography, T2-weighted signal intensity on MR imaging, histology, sulfated glycosaminoglycan (sGAG)/DNA, and associated gene expression levels, were evaluated among healthy controls without surgery, sham-operated animals in which only disc degeneration was induced, MSC-transplanted animals, and NPC-transplanted animals for a 16-week period. Results Sixteen weeks after cell transplantation, in the MSC- and NPC-transplanted groups, the decline in the disc height index was reduced and T2-weighted signal intensity increased compared with the sham-operated group. Safranin O staining showed a high GAG content, which was also supported by sGAG/DNA assessment. Disc regeneration was also confirmed at the gene expression level using real-time polymerase chain reaction. However, no significant differences in expression were found between the NPC- and MSC-transplanted groups. Conclusions Study data showed that MSC transplantation is effective for the treatment of disc degeneration and seems to be an ideal substitute for NPCs.

P34. Tissue-engineered Composite of Three Dimensional PLGA Scaffold Seeded with Nucleus Pulposus Cells for Intervertebral Disc Regeneration

2008 ◽  
Vol 8 (5) ◽  
pp. 117S-119S ◽  
Author(s):  
Chao Zhang ◽  
Ruan Dike ◽  
Rongfeng Zhang ◽  
Shenguo Wang ◽  
Fei Yang
Keyword(s):  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Three Dimensional ◽  
Plga Scaffold ◽  
Nucleus Pulposus Cells ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration

scholarly journals Intervertebral disc regeneration using platelet-rich plasma-containing bone marrow-derived mesenchymal stem cells: A preliminary investigation

2016 ◽  
Vol 13 (4) ◽  
pp. 3475-3481 ◽  
Author(s):  
SHAN-ZHENG WANG ◽  
JI-YANG JIN ◽  
YU-DONG GUO ◽  
LIANG-YU MA ◽  
QING CHANG ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Intervertebral Disc ◽  
Platelet Rich Plasma ◽  
Preliminary Investigation ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration

scholarly journals Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration

Methods ◽  
2016 ◽  
Vol 99 ◽  
pp. 69-80 ◽  
Author(s):  
Stephen M. Richardson ◽  
Gauthaman Kalamegam ◽  
Peter N. Pushparaj ◽  
Csaba Matta ◽  
Adnan Memic ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Regenerative Medicine ◽  
Intervertebral Disc ◽  
Disc Regeneration ◽  
Intervertebral Disc Regeneration
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