LINC00462 is involved in high glucose‐induced apoptosis of renal tubular epithelial cells via AKT pathway

2019 ◽  
Vol 44 (1) ◽  
pp. 286-294 ◽  
Author(s):  
Ruixin Wang ◽  
Yuehong Yan ◽  
Cuicui Li
Keyword(s):  
Epithelial Cells ◽  
High Glucose ◽  
Akt Pathway ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Renal Tubular ◽  
Induced Apoptosis

scholarly journals Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway

2017 ◽  
Vol 15 (6) ◽  
pp. 4319-4325 ◽  
Author(s):  
Min Yao ◽  
Feng Gao ◽  
Xiaomeng Wang ◽  
Yonghong Shi ◽  
Shuxia Liu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
High Glucose ◽  
Notch Pathway ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Renal Tubular ◽  
Induced Apoptosis

Zinc Modulates High Glucose-Induced Apoptosis by Suppressing Oxidative Stress in Renal Tubular Epithelial Cells

2014 ◽  
Vol 158 (2) ◽  
pp. 259-267 ◽  
Author(s):  
Xiuli Zhang ◽  
Yue Zhao ◽  
Qingqing Chu ◽  
Zhan-You Wang ◽  
Hongjuan Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
High Glucose ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Renal Tubular ◽  
Induced Apoptosis

Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells

2016 ◽  
Vol 480 (3) ◽  
pp. 387-393 ◽  
Author(s):  
Xiaocui Jiao ◽  
Ying Li ◽  
Tao Zhang ◽  
Maodong Liu ◽  
Yanqing Chi
Keyword(s):  
Epithelial Cells ◽  
High Glucose ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Renal Tubular ◽  
Induced Apoptosis

scholarly journals Burdock Fructooligosaccharide Attenuates High Glucose-Induced Apoptosis and Oxidative Stress Injury in Renal Tubular Epithelial Cells

2021 ◽  
Vol 12 ◽  
Author(s):  
Mengru Ding ◽  
Zhiyan Tang ◽  
Wei Liu ◽  
Taili Shao ◽  
Pingchuan Yuan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
High Glucose ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Stress Injury ◽  
Oxidative Stress Injury ◽  
Renal Tubular ◽  
Induced Apoptosis ◽  
And Oxidative Stress

Hyperglycemia-induced apoptosis and oxidative stress injury are thought to play important roles in the pathogenesis of diabetic nephropathy (DN). Attenuating high glucose (HG)-induced renal tubular epithelial cell injury has become a potential approach to ameliorate DN. In recent years, burdock fructooligosaccharide (BFO), a water-soluble inulin-type fructooligosaccharide extracted from burdock root, has been shown to have a wide range of pharmacological activities, including antiviral, anti-inflammatory, and hypolipidemic activities. However, the role and mechanism of BFO in rat renal tubular epithelial cells (NRK-52E cells) have rarely been investigated. The present study investigated the protective effect of BFO on HG-induced damage in NRK-52E cells. BFO could protect NRK-52E cells against the reduced cell viability and significantly increased apoptosis rate induced by HG. These anti-oxidative stress effects of BFO were related to the significant inhibition of the production of reactive oxygen species, stabilization of mitochondrial membrane potential, and increased antioxidant (superoxide dismutase and catalase) activities. Furthermore, BFO increased the expression of Nrf2, HO-1, and Bcl-2 and decreased the expression of Bax. In conclusion, these findings suggest that BFO protects NRK-52E cells against HG-induced damage by inhibiting apoptosis and oxidative stress through the Nrf2/HO-1 signaling pathway.

scholarly journals MiR-30c regulates cisplatin-induced apoptosis of renal tubular epithelial cells by targeting Bnip3L and Hspa5

2017 ◽  
Vol 8 (8) ◽  
pp. e2987-e2987 ◽  
Author(s):  
Bin Du ◽  
Xiao-meng Dai ◽  
Shuang Li ◽  
Guo-long Qi ◽  
Guang-xu Cao ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Renal Tubular ◽  
Induced Apoptosis
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