Coronary fractional flow reserve derived from intravascular ultrasound imaging: Validation of a new computational method of fusion between anatomy and physiology

2018 ◽  
Vol 93 (2) ◽  
pp. 266-274 ◽  
Author(s):  
Cristiano G. Bezerra ◽  
Alexandre Hideo‐Kajita ◽  
Carlos A. Bulant ◽  
Gonzalo D. Maso‐Talou ◽  
Jose Mariani ◽  
...  
Keyword(s):  
Intravascular Ultrasound ◽  
Ultrasound Imaging ◽  
Fractional Flow Reserve ◽  
Computational Method ◽  
Fractional Flow ◽  
Anatomy And Physiology ◽  
Intravascular Ultrasound Imaging ◽  
Flow Reserve

Diagnostic accuracy of intravascular ultrasound-derived minimal lumen area compared with fractional flow reserve

2017 ◽  
Vol 65 (3) ◽  
Author(s):  
Joao P. Lopes ◽  
Michelle K. Jordan ◽  
Hiram Bezerra ◽  
Marco A. Costa ◽  
Guilherme Attizzani
Keyword(s):  
Diagnostic Accuracy ◽  
Intravascular Ultrasound ◽  
Fractional Flow Reserve ◽  
Lumen Area ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Minimal Lumen Area

scholarly journals Comparison of Instantaneous Wave-Free Ratio (iFR) and Fractional Flow Reserve (FFR) with respect to Their Sensitivities to Cardiovascular Factors: A Computational Model-Based Study

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Xinyang Ge ◽  
Youjun Liu ◽  
Zhaofang Yin ◽  
Shengxian Tu ◽  
Yuqi Fan ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Fractional Flow Reserve ◽  
Aortic Valve Disease ◽  
Computational Method ◽  
Valve Disease ◽  
Fractional Flow ◽  
Coronary Syndrome ◽  
Flow Reserve ◽  
Large Patient ◽  
Discordant Diagnosis

While coronary revascularization strategies guided by instantaneous wave-free ratio (iFR) are, in general, noninferior to those guided by fractional flow reserve (FFR) with respect to the rate of major adverse cardiac events at one-year follow-up in patients with stable angina or an acute coronary syndrome, the overall accuracy of diagnosis with iFR in large patient cohorts is about 80% compared with the diagnosis with FFR. So far, it remains incompletely understood what factors contribute to the discordant diagnosis between iFR and FFR. In this study, a computational method was used to systemically investigate the respective effects of various cardiovascular factors on FFR and iFR. The results showed that deterioration in aortic valve disease (e.g., regurgitation or stenosis) led to a marked decrease in iFR and a mild increase in FFR given fixed severity of coronary artery stenosis and that increasing coronary microvascular resistance caused a considerable increase in both iFR and FFR, but the degree of increase in iFR was lower than that in FFR. These findings suggest that there is a high probability of discordant diagnosis between iFR and FFR in patients with severe aortic valve disease or coronary microcirculation dysfunction.

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