Fractional flow reserve from intravascular ultrasound imaging: Computational fluid dynamics to the rescue?

2019 ◽  
Vol 93 (2) ◽  
pp. 275-277 ◽  
Author(s):  
Morton J. Kern ◽  
Arnold H. Seto
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Intravascular Ultrasound ◽  
Ultrasound Imaging ◽  
Fractional Flow Reserve ◽  
Fractional Flow ◽  
Intravascular Ultrasound Imaging ◽  
Flow Reserve

Fractional flow reserve derived from conventional coronary angiograms and computational fluid dynamics

2015 ◽  
Vol 190 ◽  
pp. 187-189 ◽  
Author(s):  
Anastasios Kopanidis ◽  
Ioannis Pantos ◽  
Andreas Theodorakakos ◽  
Efthalia Tzanalaidou ◽  
Demosthenes Katritsis
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Fractional Flow Reserve ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Coronary Angiograms

scholarly journals Fractional Flow Reserve Computed from Noninvasive CT Angiography Data: Diagnostic Performance of an On-Site Clinician-operated Computational Fluid Dynamics Algorithm

Radiology ◽  
2015 ◽  
Vol 274 (3) ◽  
pp. 674-683 ◽  
Author(s):  
Adriaan Coenen ◽  
Marisa M. Lubbers ◽  
Akira Kurata ◽  
Atsushi Kono ◽  
Admir Dedic ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Ct Angiography ◽  
Fractional Flow Reserve ◽  
Diagnostic Performance ◽  
Fractional Flow ◽  
Flow Reserve

scholarly journals The relationship between coronary stenosis morphology and fractional flow reserve: a computational fluid dynamics modelling study

2021 ◽  
Author(s):  
Roberto T F Newcombe ◽  
Rebecca C Gosling ◽  
Vignesh Rammohan ◽  
Patricia V Lawford ◽  
D Rodney Hose ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Coronary Artery ◽  
Fractional Flow Reserve ◽  
Computational Modelling ◽  
Fractional Flow ◽  
Cfd Modelling ◽  
Flow Reserve ◽  
The Relationship ◽  
Lesion Severity

Abstract Background International guidelines mandate the use of fractional flow reserve (FFR) and/or non-hyperaemic pressure ratios to assess the physiological significance of moderate coronary artery lesions to guide revascularisation decisions. However, they remain underused such that visual estimation of lesion severity continues to be the predominant decision-making tool. It would be pragmatic to have an improved understanding of the relationship between lesion morphology and haemodynamics. Aims To compute virtual FFR (vFFR) in idealised coronary artery geometries with a variety of stenosis and vessel characteristics Methods Coronary artery geometries were modelled, based upon physiologically realistic branched arteries. Common stenosis characteristics were studied, including % narrowing, length, eccentricity, shape, number, position relative to branch, and distal (myocardial) resistance. Computational fluid dynamics (CFD) modelling was used to calculate vFFRs using the VIRTUheartTM system. Results Percentage lesion severity had the greatest effect upon FFR. Any ≥80% diameter stenosis in two views (i.e. concentric) was physiologically significant (FFR ≤ 0.80), irrespective of length, shape or vessel diameter. Almost all eccentric stenoses and all 50% concentric stenoses were physiologically non-significant, whilst 70% uniform concentric stenoses about 10mm long straddled the ischaemic threshold (FFR 0.80). A low microvascular resistance (MVR) reduced FFR on average by 0.05, and a high MVR increased it by 0.03. Conclusions Using computational modelling, we have produced an analysis of virtual FFR that relates stenosis characteristics to haemodynamic significance. The strongest predictor of a positive virtual FFR was a concentric, ≥80% diameter stenosis. The importance of MVR was quantified. Other lesion characteristics have a limited impact.

On-site evaluation of CT-based fractional flow reserve using simple boundary conditions for computational fluid dynamics

2019 ◽  
Vol 36 (2) ◽  
pp. 337-346 ◽  
Author(s):  
Yusuke Yoshikawa ◽  
Masahiko Nakamoto ◽  
Masanori Nakamura ◽  
Takeharu Hoshi ◽  
Erika Yamamoto ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Boundary Conditions ◽  
Fractional Flow Reserve ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Simple Boundary ◽  
Site Evaluation
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