Palladium(0)-Catalyzed Cross-Coupling of Potassium (Z)-2-Chloroalk-1-enyl Trifluoroborates: A Chemo- and Stereoselective Access to (Z)-Chloroolefins and Trisubstituted Alkenes
A regio- and stereoselective synthesis of (Z)-β-halo alkenyl sulfides via K2CO3-promoted hydrothiolation of haloalkynes has been reported, permitting a new entry to trisubstituted alkenes featuring the iterative cross-coupling of carbon–halide and carbon–sulfur bonds.
Highly Stereo- and Regioselective Synthesis of (Z)-Trisubstituted Alkenes via 1-Bromo-1-alkyne Hydroboration−Migratory Insertion−Zn-Promoted Iodinolysis and Pd-Catalyzed Organozinc Cross-Coupling