scholarly journals Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor

2018 ◽  
Vol 24 (31) ◽  
pp. 7861-7865 ◽  
Author(s):  
Franziska Kappert ◽  
Sridhar Sreeramulu ◽  
Hendrik R. A. Jonker ◽  
Christian Richter ◽  
Vladimir V. Rogov ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Small Molecule ◽  
Structural Characterization ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Allosteric Inhibitor

scholarly journals Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
Yanan Liu ◽  
Canwei Wang ◽  
Jifa Li ◽  
Jiandong Zhu ◽  
Chengguang Zhao ◽  
...  
Keyword(s):  
Growth Factor ◽  
Ligand Binding ◽  
Fibroblast Growth Factor ◽  
Small Molecule ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Cancer Development ◽  
Tyrosine Kinase Receptor ◽  
Fibroblast Growth ◽  
Receptor Family

Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding. Excessive expression of the receptor and its ligand, especially FGF19, occurs in many types of cancer. Abnormal FGFR4 production explains these cancer formations, and therefore, this receptor has emerged as a potential target for inhibiting cancer development. This review discusses the diverse mechanisms of oncogenic activation of FGFR4 and highlights some currently available inhibitors targeting FGFR4.

Biophysical characterization of drug-resistant mutants of fibroblast growth factor receptor 1

2016 ◽  
Vol 21 (10) ◽  
pp. 1049-1058 ◽  
Author(s):  
Kaito Yoza ◽  
Rika Himeno ◽  
Shinjiro Amano ◽  
Yoshihiro Kobashigawa ◽  
Shun Amemiya ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Drug Resistant ◽  
Fibroblast Growth ◽  
Biophysical Characterization ◽  
Resistant Mutants

Characterization of Fibroblast Growth Factor Receptor 1 RNA Expression in the Embryonic Mouse Heart

1995 ◽  
Vol 752 (1 Cardiac Growt) ◽  
pp. 406-416 ◽  
Author(s):  
KISHORE B. S. PASUMARTHI ◽  
YAN JIN ◽  
MARGARET E. BOCK ◽  
ARISTIDES LYTRAS ◽  
ELISSAVET KARDAMI ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Mouse Heart ◽  
Rna Expression ◽  
Fibroblast Growth ◽  
Embryonic Mouse

scholarly journals Characterization of Fibroblast Growth Factor Receptor 1 in Small-Cell Lung Cancer

2014 ◽  
Vol 9 (4) ◽  
pp. 567-571 ◽  
Author(s):  
Anish Thomas ◽  
Jih-Hsiang Lee ◽  
Zied Abdullaev ◽  
Kang-Seo Park ◽  
Marbin Pineda ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Small Cell Lung Cancer ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Small Cell ◽  
Fibroblast Growth ◽  
Small Cell Lung
Sign in / Sign up

Export Citation Format

Share Document