Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer
Keyword(s):
Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding. Excessive expression of the receptor and its ligand, especially FGF19, occurs in many types of cancer. Abnormal FGFR4 production explains these cancer formations, and therefore, this receptor has emerged as a potential target for inhibiting cancer development. This review discusses the diverse mechanisms of oncogenic activation of FGFR4 and highlights some currently available inhibitors targeting FGFR4.
2011 ◽
Vol 54
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pp. 7066-7083
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1992 ◽
Vol 11
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pp. 4273-4280
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2007 ◽
Vol 367
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pp. 111-121
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1996 ◽
Vol 271
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pp. 20119-20125
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2004 ◽
Vol 317
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pp. 253-258
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