Synthetic Approaches for 15N‐labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for 15N NMR Signal Amplification By Reversible Exchange in Microtesla Magnetic Fields

2021 ◽  
Author(s):  
Nikita V. Chukanov ◽  
Roman V. Shchepin ◽  
Sameer M. Joshi ◽  
Mohammad S. H. Kabir ◽  
Oleg G. Salnikov ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Magnetic Fields ◽  
Signal Amplification ◽  
Imaging Agents ◽  
15N Nmr ◽  
Molecular Imaging Agents ◽  
Synthetic Approaches

scholarly journals A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors

2020 ◽  
Vol 13 (8) ◽  
pp. 199
Author(s):  
Joseph Lau ◽  
Julie Rousseau ◽  
Daniel Kwon ◽  
François Bénard ◽  
Kuo-Shyan Lin
Keyword(s):  
Molecular Imaging ◽  
Smooth Muscle Contraction ◽  
Therapeutic Interventions ◽  
Imaging Agents ◽  
Kinin System ◽  
Normal Tissues ◽  
Molecular Imaging Agents ◽  
Inflammatory State ◽  
B2 Receptors ◽  
Tissue Trauma

Kinins, bradykinin and kallidin are vasoactive peptides that signal through the bradykinin B1 and B2 receptors (B1R and B2R). B2R is constitutively expressed in healthy tissues and mediates responses such as vasodilation, fluid balance and retention, smooth muscle contraction, and algesia, while B1R is absent in normal tissues and is induced by tissue trauma or inflammation. B2R is activated by kinins, while B1R is activated by kinins that lack the C-terminal arginine residue. Perturbations of the kinin system have been implicated in inflammation, chronic pain, vasculopathy, neuropathy, obesity, diabetes, and cancer. In general, excess activation and signaling of the kinin system lead to a pro-inflammatory state. Depending on the disease context, agonism or antagonism of the bradykinin receptors have been considered as therapeutic options. In this review, we summarize molecular imaging agents targeting these G protein-coupled receptors, including optical and radioactive probes that have been used to interrogate B1R/B2R expression at the cellular and anatomical levels, respectively. Several of these preclinical agents, described herein, have the potential to guide therapeutic interventions for these receptors.

scholarly journals Dual-Modality Activity-Based Probes as Molecular Imaging Agents for Vascular Inflammation

2016 ◽  
Vol 57 (10) ◽  
pp. 1583-1590 ◽  
Author(s):  
N. P. Withana ◽  
T. Saito ◽  
X. Ma ◽  
M. Garland ◽  
C. Liu ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Vascular Inflammation ◽  
Imaging Agents ◽  
Dual Modality ◽  
Molecular Imaging Agents

scholarly journals Intelligent Design of Nano-Scale Molecular Imaging Agents

2012 ◽  
Vol 13 (12) ◽  
pp. 16986-17005 ◽  
Author(s):  
Sung Kim ◽  
Mitsuru Hattori ◽  
Takeaki Ozawa
Keyword(s):  
Molecular Imaging ◽  
Intelligent Design ◽  
Imaging Agents ◽  
Nano Scale ◽  
Molecular Imaging Agents

Development of new PTK7-targeting aptamer-fluorescent and -radiolabelled probes for evaluation as molecular imaging agents: Lymphoma and melanoma in vivo proof of concept

2017 ◽  
Vol 25 (3) ◽  
pp. 1163-1171 ◽  
Author(s):  
Victoria Calzada ◽  
María Moreno ◽  
Jessica Newton ◽  
Joel González ◽  
Marcelo Fernández ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Imaging Agents ◽  
Proof Of Concept ◽  
Molecular Imaging Agents

Pre-clinical Validation of Near-Infrared Molecular Imaging Agents and Devices for Intraoperative Guidance

2013 ◽  
Author(s):  
Eva M. Sevick-Muraca ◽  
Banghe Zhu ◽  
Barrett R. Harvey ◽  
Mary A. Hall ◽  
Kenneth L. Pinkston ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Near Infrared ◽  
Imaging Agents ◽  
Clinical Validation ◽  
Molecular Imaging Agents ◽  
Intraoperative Guidance
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