scholarly journals Self‐Propelling Hybrid Gels Incorporating an Active Self‐Assembled Low‐Molecular‐Weight Gelator

2021 ◽  
Author(s):  
Carmen C. Piras ◽  
David K. Smith
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Hybrid Gels ◽  
Self Assembled ◽  
Low Molecular Weight Gelator

scholarly journals In between molecules and self-assembled fibrillar networks: highly stable nanogel particles from a low molecular weight hydrogelator

Soft Matter ◽  
2019 ◽  
Vol 15 (17) ◽  
pp. 3565-3572 ◽  
Author(s):  
Ana Torres-Martínez ◽  
César A. Angulo-Pachón ◽  
Francisco Galindo ◽  
Juan F. Miravet
Keyword(s):  
Thermal Stability ◽  
Molecular Weight ◽  
Low Molecular Weight ◽  
Self Assembled ◽  
Low Molecular Weight Gelator

A low molecular weight gelator forms reproducibly nanogel particles with good temporal and thermal stability and they present accessible hydrophobic domains.

scholarly journals Self-assembled low-molecular-weight gelator injectable microgel beads for delivery of bioactive agents

2021 ◽  
Author(s):  
Carmen C. Piras ◽  
Alasdair G. Kay ◽  
Paul G. Genever ◽  
David K. Smith
Keyword(s):  
Molecular Weight ◽  
Stem Cell ◽  
Cell Growth ◽  
Low Molecular Weight ◽  
Interpenetrating Networks ◽  
Delivery Vehicles ◽  
Self Assembled ◽  
Bioactive Agents ◽  
Enhance Stem Cell ◽  
Low Molecular Weight Gelator

We report microgel beads with diameters of ca. 800 nm based on interpenetrating networks of a low-molecular-weight gelator and a polymer gelator, and demonstrate their use as heparin delivery vehicles to enhance stem cell growth.

scholarly journals Wet spinning and radial self-assembly of a carbohydrate low molecular weight gelator into well organized hydrogel filaments

Nanoscale ◽  
2019 ◽  
Vol 11 (32) ◽  
pp. 15043-15056 ◽  
Author(s):  
Anaïs Chalard ◽  
Pierre Joseph ◽  
Sandrine Souleille ◽  
Barbara Lonetti ◽  
Nathalie Saffon-Merceron ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Self Assembly ◽  
Radial Diffusion ◽  
Wet Spinning ◽  
Low Molecular Weight ◽  
Diffusion Phenomena ◽  
Self Assembled ◽  
Low Molecular Weight Gelator

A molecular gel self-assembled by wet spinning forms ultra-hydrated continuous gel filaments and reveals the solvent's radial diffusion phenomena.

scholarly journals Thermally tunable selective formation of self-assembled fibers into two orthogonal directions in oriented liquid-crystalline smectic templates

2020 ◽  
Vol 56 (69) ◽  
pp. 9954-9957
Author(s):  
Daisuke Yamaguchi ◽  
Yuka Ikemoto ◽  
Takashi Kato
Keyword(s):  
Molecular Weight ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Layered Structures ◽  
Low Molecular Weight ◽  
Smectic A ◽  
Orthogonal Grid ◽  
Self Assembled ◽  
Low Molecular Weight Gelators ◽  
Selective Formation

Two orthogonal (grid-like) and one directional fibrous structures are selectively formed through anisotropic self-assembly of low-molecular-weight gelators in liquid-crystalline smectic A templates depending on thermally tuned layered structures.

Diaminomalenonitrile-decorated cholesterol-based supramolecular gelator: aggregation, multiple analyte (hydrazine, Hg2+ and Cu2+) detection and dye adsorption

2018 ◽  
Vol 42 (16) ◽  
pp. 13718-13725 ◽  
Author(s):  
Atanu Panja ◽  
Kumaresh Ghosh
Keyword(s):  
Molecular Weight ◽  
Functional Group ◽  
Dye Adsorption ◽  
Low Molecular Weight ◽  
Practical Applications ◽  
Supramolecular Gels ◽  
Low Molecular Weight Gelator

A low molecular weight gelator (LMWG) containing a diaminomalenonitrile functional group 1 forms supramolecular gels from DMF–H2O and 1,2-dichlorobenzene. The DMF/H2O gel is multi-analyte responsive (Hg2+, Cu2+ and hydrazine) with practical applications in dye adsorption from water.

scholarly journals Novel Hybrid Gels Made of High and Low Molecular Weight Hyaluronic Acid Induce Proliferation and Reduce Inflammation in an Osteoarthritis In Vitro Model Based on Human Synoviocytes and Chondrocytes

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Antonietta Stellavato ◽  
Valentina Vassallo ◽  
Annalisa La Gatta ◽  
Anna Virginia Adriana Pirozzi ◽  
Mario De Rosa ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Time Lapse ◽  
Human Chondrocytes ◽  
Low Molecular Weight ◽  
Hybrid Gels ◽  
Normal Functions ◽  
Human Primary Cells ◽  
Anti Inflammatory ◽  
Vitro Model

High molecular weight hyaluronan (H-HA) has a pivotal role in the maintenance of normal functions of synovial fluid and structure of the articular joint, but it has been shown that its concentration is reduced in patients affected by degenerative cartilage diseases, such as osteoarthritis (OA). The aim of this study was to investigate the anti-inflammatory effects and properties of hybrid cooperative complexes based on high and low molecular weight hyaluronan (HCC) compared to H-HA on human primary cells derived by pathological joints. In addition, the rheological behavior of HCC was evaluated in order to define their potential as viscosupplement gel in degenerated joints. The experiments were performed using an in vitro model of OA based on human chondrocytes and synoviocytes isolated from degenerated joints of patients hospitalized for surgical replacement. In order to assess the anti-inflammatory effects of HCC, we evaluated NF-kB, COMP-2, IL-6, and IL-8 as specific markers at the transcriptional and/or protein level. Moreover, the proliferative properties of HCC were assessed using time lapse video microscopy. We showed that chondrocytes and synoviocytes clearly presented an altered cytokine profile compatible with a severe ongoing inflammation status. H-HA and, above all, HCC significantly reduced levels of the specific biomarkers evaluated and improved cartilage healing. The rheological profile indicated HCC suitability for intra-articular injection in joint diseases. HCC viscoelastic properties and the protective/anti-inflammatory effect on human chondrocytes and synoviocytes suggest the novel HCC-based gels as a valid support for OA management.

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