scholarly journals Sandacrabins – Structurally unique antiviral RNA polymerase inhibitors from a rare myxobacterium

2022 ◽  
Author(s):  
Chantal D. Bader ◽  
Fabian Panter ◽  
Ronald Garcia ◽  
Egor P. Tchesnokov ◽  
Sibylle Haid ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Polymerase Inhibitors

scholarly journals The Fight against the Influenza A Virus H1N1: Synthesis, Molecular Modeling, and Biological Evaluation of Benzofurazan Derivatives as Viral RNA Polymerase Inhibitors

ChemMedChem ◽  
2013 ◽  
Vol 9 (1) ◽  
pp. 129-150 ◽  
Author(s):  
Mafalda Pagano ◽  
Daniele Castagnolo ◽  
Martina Bernardini ◽  
Anna Lucia Fallacara ◽  
Ilaria Laurenzana ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Rna Polymerase ◽  
Influenza A Virus ◽  
Influenza A ◽  
Biological Evaluation ◽  
Viral Rna ◽  
Virus H1n1 ◽  
Polymerase Inhibitors

scholarly journals Structure-Based Ligand Design of Novel Bacterial RNA Polymerase Inhibitors

2011 ◽  
Vol 2 (10) ◽  
pp. 729-734 ◽  
Author(s):  
Martin J. McPhillie ◽  
Rachel Trowbridge ◽  
Katherine R. Mariner ◽  
Alex J. O’Neill ◽  
A. Peter Johnson ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Ligand Design ◽  
Polymerase Inhibitors ◽  
Bacterial Rna

scholarly journals RNA Polymerase Inhibitors with Activity against Rifampin-Resistant Mutants of Staphylococcus aureus

2000 ◽  
Vol 44 (11) ◽  
pp. 3163-3166 ◽  
Author(s):  
Alexander O'Neill ◽  
Brunello Oliva ◽  
Christopher Storey ◽  
Anthony Hoyle ◽  
Colin Fishwick ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Drug Development ◽  
Rna Polymerase ◽  
Gene Mutations ◽  
Β Subunit ◽  
Polymerase Inhibitors ◽  
Resistant Mutants ◽  
Sorangicin A

ABSTRACT A collection of rifampin-resistant mutants of Staphylococcus aureus with characterized RNA polymerase β-subunit (rpoB) gene mutations was cross-screened against a number of other RNA polymerase inhibitors to correlate susceptibility with specific rpoB genotypes. The rpoB mutants were cross-resistant to streptolydigin and sorangicin A. In contrast, thiolutin, holomycin, corallopyronin A, and ripostatin A retained activity against the rpoB mutants. The second group of inhibitors may be of interest as drug development candidates.

scholarly journals Further Characterization ofBacillus subtilisAntibiotic Biosensors and Their Use for Antibacterial Mode-of-Action Studies

2011 ◽  
Vol 55 (4) ◽  
pp. 1784-1786 ◽  
Author(s):  
Katherine R. Mariner ◽  
Nicola Ooi ◽  
Deborah Roebuck ◽  
Alex J. O'Neill ◽  
Ian Chopra
Keyword(s):  
Bacillus Subtilis ◽  
Rna Polymerase ◽  
Mode Of Action ◽  
Trna Synthetase ◽  
Dna Intercalators ◽  
Peptidoglycan Synthesis ◽  
Modes Of Action ◽  
Polymerase Inhibitors

ABSTRACTWe further examined the usefulness of previously reportedBacillus subtilisbiosensors for antibacterial mode-of-action studies. The biosensors could not detect the tRNA synthetase inhibitors mupirocin, indolmycin, and borrelidin, some inhibitors of peptidoglycan synthesis, and most membrane-damaging agents. However, the biosensors confirmed the modes of action of several RNA polymerase inhibitors and DNA intercalators and provided new insights into the possible modes of action of ciprofloxacin, anhydrotetracycline, corralopyronin, 8-hydroxyquinoline, and juglone.

Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part II: Sulfonamides

2005 ◽  
Vol 2 (6) ◽  
pp. 456-461 ◽  
Author(s):  
S. Ponzi ◽  
C. Giuliano ◽  
M. Donghi ◽  
M. Poma ◽  
V. Matassa ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Dependent Rna Polymerase ◽  
Polymerase Inhibitors ◽  
Hcv Ns5b
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