Aims:
A series of six 4-benzylidene-2-((1-phenyl-3,4-dihydro isoquinoline-2(1H)-yl)methyloxazol-
5(4H)-one derivatives were synthesized by condensation of substituted aryl aldehydes with 2-(2-(1-phenyl-3,4-
dihydro isoquinoline-2(1H)-acetamido)acetic acid in the presence of sodium acetate, acetic anhydride and zinc
oxide as catalysts.
Background:
Novel Synthesis of 4-Benzylidene-2-((1-phenyl-3,4-dihy droisoquinoline-2(1H)-yl)methyl)oxazol-
5(4H)-one derivatives using 1,2,3,Tetrahydroisoquinoline and their antimicrobial activity.
Objective:
The title compounds can be synthesized from 1,2,3,4-tetrahydroisoquinoline.
Methods:
The target molecules, i.e., 4-benzylidene-2-((1-phenyl-3, 4-dihydro isoquinoline-2(1H)-yl) methyl)
oxazol-5(4H)-one derivatives (8a-8f) have been synthesized from 1,2,3,4-tetrahydroisoquinoline which was
prepared from benzoic acid in few steps.
Results:
All the six compounds were evaluated based on advanced spectral data (1H NMR, 13C NMR &
LCMS), and the chemical structures of all compounds were determined by elemental analysis.
Conclusion:
Antibacterial activity of the derivatives was examined for the synthesized compounds and results
indicate that compound with bromine substitution has a good activity profile.
Chalcogen Bond versus Weak Hydrogen Bond: Changing Contributions in Determining the Crystal Packing of [1,2,5]-Chalcogenadiazole-Fused Tetracyanonaphthoquinodimethanes