Green and efficient synthesis of 1, 2, 4-Triazolidine-3-thiones using guanidine hydrochloride as a recyclable catalyst under the aqueous condition

A rapid and highly efficient methodology for the synthesis of 1, 2, 4-Triazolidine-3-thiones derivatives has been developed in the presence of a catalytic amount of guanidine hydrochloride using water as a solvent. The reaction of thiosemicarbazide with different aryl aldehydes resulted in the formation of title compounds in good yields (85% -95%) with a convenient reaction time (20-30 min). The key advantages of this approach are shorter reaction time, energy efficiency, easy work-up procedure, and wide substrate scope tolerance. Further, the catalyst was recycled without significant loss of its catalytic activity

Insights into Cascade and Sequential one pot pathways for reductive amination of aldehydes paired with bio-derived levulinic acid to N-substituted pyrrolidones using molecular hydrogen

This work aims to explore cascade and sequential one pot syntheses pathways for N-substituted pyrrolidones from aryl aldehydes and bio-derived levulinic acid (LA) using molecular hydrogen and ammonia. This process...

Facile Preparation of Aryl Nitriles from Aryl Aldehydes in PEG-DME 250

: A facie and efficient method for one-pot transformation of aryl aldehydes to aryl nitriles using hydroxylamine hydrochloride and phosphorus tribromide in PEG-DME 250 is reported. The conversion of various aryl aldehydes to the corresponding aryl nitriles occurred smoothly in high yields under the present reaction conditions.

Copper ferrite catalyst for direct arylation of acidic C-H bonds in azoles with aryl aldehydes

Coupling reagents toward direct arylation of C2-H bonds in aryl azoles are often limited to aryl halides. Herein we report a functionalization of the acidic sp2 C-H bonds in benzothiazoles with benzaldehyde derivatives. Reactions proceeded in the presence of commercially ready CuFe2O4 catalyst. Scope of functional groups included chloro, nitro, cyano, and ester groups.