ChemInform Abstract: Clerodane Diterpenoids and Related Natural Products: Biological Properties and Synthetic Studies

ChemInform ◽  
1989 ◽  
Vol 20 (33) ◽  
Author(s):  
A. S. SARMA
Keyword(s):  
Natural Products ◽  
Biological Properties ◽  
Clerodane Diterpenoids ◽  
Synthetic Studies

Synthetic studies on biologically active natural products by a chemicoenzymatic approach

Tetrahedron ◽  
1984 ◽  
Vol 40 (1) ◽  
pp. 145-152 ◽  
Author(s):  
Masaji Ohno ◽  
Yukishige Ito ◽  
Masafumi Arita ◽  
Tomoyuki Shibata ◽  
Kunitomo Adachi ◽  
...  
Keyword(s):  
Natural Products ◽  
Biologically Active ◽  
Synthetic Studies ◽  
Active Natural

ChemInform Abstract: Synthetic Studies on Natural Products. Part 69. A New Strategy for the Synthesis of Crucigasterin A, and Cytotoxic Activity of this Compound and Its Related Analogues.

ChemInform ◽  
2014 ◽  
Vol 45 (4) ◽  
pp. no-no
Author(s):  
Jayprakash Narayan Kumar ◽  
Parigi Raghavendra Reddy ◽  
Biswanath Das ◽  
C. Ganesh Kumar ◽  
Pombala Sujitha
Keyword(s):  
Natural Products ◽  
Cytotoxic Activity ◽  
New Strategy ◽  
Synthetic Studies

Synthesis of new cyclopeptide analogues of the miuraenamides

2021 ◽  
Vol 18 ◽  
Author(s):  
Sarah Kappler ◽  
Andreas Siebert ◽  
Uli Kazmaier
Keyword(s):  
Natural Products ◽  
Biological Properties ◽  
Amide Bond ◽  
Side Chain ◽  
Aromatic Side Chain ◽  
Highly Active ◽  
C Terminus ◽  
Terminal Amino ◽  
High Cytotoxicity ◽  
Derivatives Of

Introduction: Miuraenamides belong to marine natural compounds with interesting biological properties. Materials and Methods: They initiate polymerization of monomeric actin and therefore show high cytotoxicity by influencing the cytoskeleton. New derivatives of the miuraenamides have been synthesized containing a N-methylated amide bond instead of the more easily hydrolysable ester in the natural products. Results: Incorporation of an aromatic side chain onto the C-terminal amino acid of the tripeptide fragment also led to highly active new miuraenamides. Conclusion: We could show that the ester bond of the natural product miuraenamide can be replaced by an N-methyl amide. The yields in the cyclization step are high and generally much better that with the corresponding esters. On the other hand, the biological activity of the new amide analogs are lower compared to the natural products, but the activity can significantly be increased by incorporation of a p-nitrophenyl group at the C-terminus of the peptide fragment.

The [4.3.0] piperidine alkaloids: architectures, biology, biosyntheses and the complete details of the asymmetric syntheses of streptazone A and abikoviromycin

Synlett ◽  
2021 ◽  
Author(s):  
Gustav J. Wørmer ◽  
Thomas Bjørnskov Poulsen
Keyword(s):  
Natural Products ◽  
Biological Properties ◽  
Piperidine Alkaloids ◽  
Complete Coverage ◽  
Asymmetric Syntheses ◽  
Concise Overview ◽  
Michael Acceptors

Piperidine alkaloids continue to challenge the synthetic community by featuring densely functionalized scaffolds which often requires careful chemical orchestration. Streptazone A and abikoviromycin are small and highly functionalized piperidine alkaloids both accommodating Michael acceptors and a labile epoxide. These moieties are loaded into a [4.3.0] bicyclic core also present in other structurally related natural products including the well-known piperidine alkaloid streptazolin. Herein, we cover ring-closing strategies employed in prior streptazolin syntheses, provide a concise overview of structures, biological properties and biosyntheses of selected [4.3.0] piperidine alkaloids, and finally we disclose a complete coverage of our recent asymmetric syntheses of streptazone A and abikoviromycin.

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