ChemInform Abstract: Regioselective Syntheses of Ether-Linked Porphyrin Dimers and Trimers Related to Photofrin-II.

ChemInform ◽  
2010 ◽  
Vol 23 (12) ◽  
pp. no-no
Author(s):  
R. K. PANDEY ◽  
F.-Y. SHIAU ◽  
T. J. DOUGHERTY ◽  
K. M. SMITH
Keyword(s):  
Photofrin Ii ◽  
Porphyrin Dimers

The Photodynamic Therapy (PDT) Anticancer Activity of a Range of Porphyrin Dimers and Related Compounds Derived from Hematoporphyrin

2004 ◽  
Vol 57 (11) ◽  
pp. 1091 ◽  
Author(s):  
Christopher J. Byrne ◽  
Mathew A. Cooper ◽  
Prudence A. Cowled ◽  
Robert A. W. Johnstone ◽  
Lorraine Mackenzie ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Anticancer Activity ◽  
Side Chains ◽  
Hematoporphyrin Derivative ◽  
Synthetic Compounds ◽  
Photofrin Ii ◽  
Photodynamic Activity ◽  
Related Compounds ◽  
Porphyrin Dimers

The synthesis of diporphyrins and analogous compounds related to those present in the oligomeric fraction (Photofrin II) obtained from hematoporphyrin derivative (HPD) is described. The photodynamic activity of these compounds, in vivo, varies from inactive to as active as Photofrin II. Factors that are important in determining this anticancer activity of the synthetic compounds are the presence of hydrophobic side chains, as well as the propionic acid side chains of the hematoporphyrin derived materials, and the nature of the linking group between the porphyrins.

Regioselective syntheses of ether-linked porphyrin dimers and trimers related to photofrin-II®

Tetrahedron ◽  
1991 ◽  
Vol 47 (46) ◽  
pp. 9571-9584 ◽  
Author(s):  
Ravindra K. Pandey ◽  
Fuu-Yau Shiau ◽  
Thomas J. Dougherty ◽  
Kevin M. Smiths
Keyword(s):  
Photofrin Ii ◽  
Porphyrin Dimers

scholarly journals Adventures in molecular recognition. The ins and outs of templating

2000 ◽  
Vol 72 (12) ◽  
pp. 2265-2274 ◽  
Author(s):  
Jeremy K. M. Sanders
Keyword(s):  
Molecular Recognition ◽  
Combinatorial Chemistry ◽  
Biological Systems ◽  
Design Approach ◽  
Supramolecular Systems ◽  
Disulfide Exchange ◽  
Dynamic Combinatorial Chemistry ◽  
Evolutionary Features ◽  
Selection Approach ◽  
Porphyrin Dimers

Two different approaches are described for the creation of supramolecular systems potentially capable of recognition and catalysis. Using the design approach, we have been able to accelerate and influence two different Diels­Alder reactions within the cavities of porphyrin dimers and trimers; this is templating from the outside inwards. The selection approach is a synthetic chemical attempt to capture some of the key evolutionary features of biological systems: dynamic combinatorial chemistry is used to create equilibrating mixtures of potential receptors, and then a template is used to select and amplify the desired system. Five potential reactions for such dynamic chemistry are discussed: base-catalyzed transesterification, hydrazone exchange, disulfide exchange, alkene metathesis, and Pd-catalyzed allyl exchange, and preliminary templating results (inside outwards) are presented.

Clinical LIF pharmacokinetic measurements with Photofrin II for optimizing the photodetection of early cancer

1992 ◽  
Author(s):  
Daniel Braichotte ◽  
Georges A. Wagnieres ◽  
J. M. Philippoz ◽  
Roland Bays ◽  
Hans-Beat Ris ◽  
...  
Keyword(s):  
Early Cancer ◽  
Photofrin Ii

Excited-state properties of water-soluble porphyrin dimers

1986 ◽  
Vol 130 (6) ◽  
pp. 555-559 ◽  
Author(s):  
U. Hofstra ◽  
R.B.M. Koehorst ◽  
T.J. Schaafsma
Keyword(s):  
Excited State ◽  
Water Soluble ◽  
Water Soluble Porphyrin ◽  
Porphyrin Dimers

Self-assembly of chiral-twisted porphyrin dimers

2000 ◽  
Vol 24 (3) ◽  
pp. 113-114 ◽  
Author(s):  
Mutsumi Kimura ◽  
Takuya Kitamura ◽  
Motonori Sano ◽  
Tsuyoshi Muto ◽  
Kenji Hanabusa ◽  
...  
Keyword(s):  
Self Assembly ◽  
Porphyrin Dimers

Sonodynamically induced antitumor effect of Photofrin II on colon 26 carcinoma

2000 ◽  
Vol 126 (10) ◽  
pp. 601-606 ◽  
Author(s):  
Nagahiko Yumita ◽  
Ryuichiro Nishigaki ◽  
Shin-ichiro Umemura
Keyword(s):  
Antitumor Effect ◽  
Colon 26 ◽  
Photofrin Ii

Two- and four-armed hetero porphyrin dimers: Influence of the number of arms on the stability and specific recognition behaviour

2021 ◽  
Author(s):  
Masaki Ueda ◽  
Masaki Kimura ◽  
Shinobu Miyagawa ◽  
Masaya Naito ◽  
Hikaru Takaya ◽  
...  
Keyword(s):  
Salt Bridges ◽  
Specific Recognition ◽  
Self Assembled ◽  
The Stability ◽  
Porphyrin Dimers

In this study we self-assembled the four-armed porphyrin hetero dimer capsule Cap4, stabilized through amidinium–carboxylate salt bridges, in CH2Cl2 and CHCl3. The dimer capsule Cap4 was kinetically and thermodynamically more...

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