ChemInform Abstract: Chiral Oxazolidinones from N-Boc Derivatives of β-Amino Alcohols. Effect of a N-Methyl Substituent on Reactivity and Stereoselectivity.

ChemInform ◽  
2010 ◽  
Vol 24 (40) ◽  
pp. no-no
Author(s):  
C. AGAMI ◽  
F. COUTY ◽  
L. HAMON ◽  
O. VENIER
Keyword(s):  
Amino Alcohols ◽  
Methyl Substituent ◽  
Derivatives Of

Chiral oxazolidinones from N-Boc derivatives of β-amino alcohols. Effect of a N-methyl substituent on reactivity and stereoselectivity

1993 ◽  
Vol 34 (28) ◽  
pp. 4509-4512 ◽  
Author(s):  
Claude Agami ◽  
François Couty ◽  
Louis Hamon ◽  
Olivier Venier
Keyword(s):  
Amino Alcohols ◽  
Methyl Substituent ◽  
Derivatives Of

Coupling of Steroid O-(Carboxymethyl)oxime Derivatives with Amino Alcohols

1996 ◽  
Vol 61 (2) ◽  
pp. 288-297 ◽  
Author(s):  
Vladimír Pouzar ◽  
Ivan Černý
Keyword(s):  
Amino Acids ◽  
Hydroxy Group ◽  
Building Blocks ◽  
Amino Alcohols ◽  
New Approach ◽  
Alternative Synthesis ◽  
Oxime Derivatives ◽  
A Chain ◽  
Derivatives Of

New approach to the preparation of steroids with connecting bridge, based on an O-carboxymethyloxime (CMO) structure, and with terminal hydroxy group, is presented. 17-CMO derivatives of 3β-acetoxy- and 3β-methoxymethoxyandrost-5-en-17-one were condensed with α,ω-amino alcohols to give derivatives with a chain of seven to nine atoms. After THP-protection, these compounds were converted to 3-keto-4-ene derivatives. An alternative synthesis consisted in transformation of 17-CMO derivatives with bonded amino acids by reduction of the terminal carboxyl. The resulting compounds were designed as building blocks for the preparation of bis-haptens for sandwich immunoassays.

Studies in the Phenanthrene Series. XVI. Amino Alcohols and Miscellaneous Derivatives of Phenanthrene1

1938 ◽  
Vol 60 (6) ◽  
pp. 1321-1325 ◽  
Author(s):  
Jacob van de Kamp ◽  
Alfred Burger ◽  
Erich Mosettig
Keyword(s):  
Amino Alcohols ◽  
Derivatives Of

scholarly journals Synthesis and antitrypanosomal activities of a series of 7-deaza-5'-noraristeromycin derivatives with variations in the cyclopentyl ring substituents.

1997 ◽  
Vol 41 (8) ◽  
pp. 1658-1661 ◽  
Author(s):  
K L Seley ◽  
S W Schneller ◽  
D Rattendi ◽  
S Lane ◽  
C J Bacchi
Keyword(s):  
Methyl Substituent ◽  
Prototype Structure ◽  
Growth Activity ◽  
Derivatives Of ◽  
Related Compounds

Previous work in our laboratories has suggested that (+)-5'-nor-7-deazaaristeromycin (compound 1) may represent a prototype structure for a series of compounds with significant antitrypanosomal activities. To test this possibility, a series of derivatives of compound 1 with changes in the cyclopentyl substituents (compounds 3 to 10) have been studied. Although some growth activity was obtained with the L-like compound 5, related compounds 3 and 7 had little or no activity below 100 microM. D-like compounds 4 and 6 showed some activity at or below 100 microM, but the most interesting finding was that both the D- and L-like compounds having a methyl substituent on the 4' position were most active.

Reactions of alkoxy and amino derivatives of silacyclobutane with amino alcohols

2006 ◽  
Vol 76 (6) ◽  
pp. 931-935 ◽  
Author(s):  
V. A. Pestunovich ◽  
N. F. Lazareva ◽  
A. I. Albanov ◽  
E. N. Buravtseva ◽  
L. E. Gusel’nikov
Keyword(s):  
Amino Alcohols ◽  
Amino Derivatives ◽  
Derivatives Of

Chromatography of organometallic and organometalloidal derivatives of amino alcohols

1980 ◽  
Vol 200 ◽  
pp. 105-114 ◽  
Author(s):  
V.D. Shatz ◽  
V.A. Belikov ◽  
G.I. Zelchan ◽  
I.I. Solomenikiova ◽  
N.P. Yerchak ◽  
...  
Keyword(s):  
Amino Alcohols ◽  
Derivatives Of

Further studies of the diazo coupling reactions of pyrimidines

1983 ◽  
Vol 36 (8) ◽  
pp. 1659 ◽  
Author(s):  
DT Hurst
Keyword(s):  
Coupling Reactions ◽  
Methyl Substituent ◽  
Diazo Coupling ◽  
Acetyl Group ◽  
Derivatives Of

6-Arylazo derivatives of the following pyrimidines have been obtained: 2-acetamido-4,5-dihydroxy-, 4-amino-2,5-dihydroxy-, 2,4-diamino-5-hydroxy- and 4-amino-5-hydroxy-2-methyl-pyrimidine. However, some 5-substituted pyrimidines having other electron-releasing groups failed to undergo diazo coupling. 2,4-Dihydroxypyrimidin-5-yl acetate and 2-acetamido-4-hydroxypyrimidin-5-yl acetate lost the 5-acetyl group during the introduction of the arylazo group into the 6-position. However, 2-hydroxy-4,6-dimethylpyrimidin-5-yl acetate undergoes diazo coupling at the 4(6)-methyl substituent without loss of the 5-acetyl group. The mechanisms for these diazo couplings are discussed.

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