ChemInform Abstract: Isolation and Structure of Chaetomellic Acids A and B from Chaetomella acutiseta: Farnesyl Pyrophosphate Mimic Inhibitors of Ras Farnesyl- Protein Transferase.

ChemInform ◽  
2010 ◽  
Vol 24 (43) ◽  
pp. no-no ◽  
Author(s):  
S. B. SINGH ◽  
D. L. ZINK ◽  
J. M. LIESCH ◽  
M. A. GOETZ ◽  
R. G. JENKINS ◽  
...  
Keyword(s):  
Farnesyl Pyrophosphate ◽  
Farnesyl Protein Transferase

Phosphonate and bisphosphonate analogues of farnesyl pyrophosphate as potential inhibitors of farnesyl protein transferase

1998 ◽  
Vol 6 (6) ◽  
pp. 687-694 ◽  
Author(s):  
Sarah A Holstein ◽  
Diana M Cermak ◽  
David F Wiemer ◽  
Kriste Lewis ◽  
Raymond J Hohl
Keyword(s):  
Farnesyl Pyrophosphate ◽  
Farnesyl Protein Transferase ◽  
Potential Inhibitors

scholarly journals Ubiquitin-RAS peptide extensions as substrates for farnesyl-protein transferase and carboxymethyltransferase

1992 ◽  
Vol 285 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Y Yoo ◽  
S Watts ◽  
M Rechsteiner
Keyword(s):  
Heat Treatment ◽  
Binding Assay ◽  
Rabbit Reticulocyte Lysate ◽  
Farnesyl Pyrophosphate ◽  
Xenopus Egg Extract ◽  
Egg Extract ◽  
Farnesyl Protein Transferase ◽  
Reticulocyte Lysate ◽  
One Step ◽  
Xenopus Egg

Using oligonucleotide-mediated ‘loop-in’ mutagenesis strategies in M13, a heat-inducible ubiquitin (Ub) gene was extended by sequences coding for the C-terminal 11 amino acids of Ha-RAS. The resulting gene was transformed into AR13 and production of the Ub-peptide extension was induced by heat treatment. After one-step purification, the fusion protein (Ub-cRAS) was used as a substrate for farnesyl-protein transferase. Ub-cRAS was farnesylated on incubation in Xenopus egg extract or rabbit reticulocyte lysate. In contrast, when serine was substituted for the last cysteine in the RAS extension, transfer of the [3H]farnesyl group from [3H] farnesyl pyrophosphate to the modified Ub-cRAS was not observed. Farnesylation of Ub-cRAS permitted us to develop an easy membrane-binding assay for farnesyl-protein transferase enzyme activity. Using this assay, we partially purified the enzyme from rabbit reticulocyte lysate. We also detected methylation of the farnesylated Ub-cRAS terminus in Xenopus egg extract.

Isolation and structure of chaetomellic acids A and B from Chaetomella acutiseta: farnesyl pyrophosphate mimic inhibitors of ras farnesyl-protein transferase

Tetrahedron ◽  
1993 ◽  
Vol 49 (27) ◽  
pp. 5917-5926 ◽  
Author(s):  
Sheo B. Singh ◽  
Deborah L. Zink ◽  
Jerrold M. Liesch ◽  
Michael A. Goetz ◽  
Rosalind G. Jenkins ◽  
...  
Keyword(s):  
Farnesyl Pyrophosphate ◽  
Farnesyl Protein Transferase

Cloning and characterization of Farnesyl pyrophosphate synthase gene from Anoectochilus

2019 ◽  
Vol 52 (3) ◽  
Author(s):  
Lin Yang ◽  
Jun Cheng Zhang ◽  
Wan Chen Li ◽  
Jing Tao Qu ◽  
Hao Qiang Yu ◽  
...  
Keyword(s):  
Farnesyl Pyrophosphate ◽  
Farnesyl Pyrophosphate Synthase

scholarly journals Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

1993 ◽  
Vol 268 (11) ◽  
pp. 7617-7620
Author(s):  
J.B. Gibbs ◽  
D.L. Pompliano ◽  
S.D. Mosser ◽  
E. Rands ◽  
R.B. Lingham ◽  
...  
Keyword(s):  
Selective Inhibition ◽  
Farnesyl Protein Transferase

Brain Isoprenoids Farnesyl Pyrophosphate and Geranylgeranyl Pyrophosphate are Increased in Aged Mice

2012 ◽  
Vol 46 (1) ◽  
pp. 179-185 ◽  
Author(s):  
Gero P. Hooff ◽  
W. Gibson Wood ◽  
Ji-Hyun Kim ◽  
Urule Igbavboa ◽  
Wei-Yi Ong ◽  
...  
Keyword(s):  
Farnesyl Pyrophosphate ◽  
Geranylgeranyl Pyrophosphate ◽  
Aged Mice

scholarly journals Unusual Farnesyl Pyrophosphate Synthetase Reaction of an Artificial Substrate with Ni2+

1986 ◽  
Vol 15 (11) ◽  
pp. 1885-1888 ◽  
Author(s):  
Yuji Maki ◽  
Gotaro Watanabe ◽  
Akio Saito ◽  
Tanetoshi Koyama ◽  
Kyozo Ogura
Keyword(s):  
Artificial Substrate ◽  
Farnesyl Pyrophosphate
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