ChemInform Abstract: Enynones in Organic Synthesis. Part 7. Substituent Effects on the . alpha.-Tocopherol-Catalyzed Cyclization of Enynones to Methylenecyclopentenones. Convenient Syntheses of Members of the Methylenomycin Class of Antibiotics.

ChemInform ◽  
2010 ◽  
Vol 26 (10) ◽  
pp. no-no
Author(s):  
P. A. JACOBI ◽  
H. L. BRIELMANN ◽  
R. O. CANN
Keyword(s):  
Organic Synthesis ◽  
Substituent Effects ◽  
Alpha Tocopherol

scholarly journals Substituent Effects on Solvent-Free Synthesis (MWAOS) of Dihydroquinazolinones by the Addition of Isatoic Anhydride to a Series of Phenyl-Substituted N-(Phenylmethylidene) Anilines

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Abhilash Mullasseril
Keyword(s):  
Organic Synthesis ◽  
Substituent Effects ◽  
Microwave Oven ◽  
Solvent Free ◽  
Isatoic Anhydride ◽  
Atom Economy ◽  
Microwave Assisted ◽  
Solvent Free Synthesis

The present study concentrates on the synthesis of a series of dihydroquinazolinones by applying the green concept Microwave Assisted Organic Synthesis (MWAOS) with high atom economy. A series of phenyl-substituted N-(phenylmethylidene) anilines are coupled with isatoic anhydride using a microwave oven.

Mass Spectrometry in Organic Synthesis: Claisen–Schmidt Base-Catalyzed Condensation and Hammett Correlation of Substituent Effects

2014 ◽  
Vol 91 (11) ◽  
pp. 1985-1989 ◽  
Author(s):  
Ryan M. Bain ◽  
Christopher J. Pulliam ◽  
Xin Yan ◽  
Kassandra F. Moore ◽  
Thomas Müller ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Organic Synthesis ◽  
Substituent Effects ◽  
Hammett Correlation

Lithiated γ-Tosyl-Substituted Benzylmethallylamine:  New γ-Amino Methallyl Sulfone Anions in Organic Synthesis

1997 ◽  
Vol 62 (5) ◽  
pp. 1564-1564
Author(s):  
Diego A. Alonso ◽  
Larry R. Falvello ◽  
Balbino Mancheño ◽  
Carmen Nájera ◽  
Milagros Tomás
Keyword(s):  
Organic Synthesis

Alpha-Tocopherol Protects Cultured Human Cells from the Acute Lethal Cytotoxicity of Dioxin

2002 ◽  
Vol 72 (3) ◽  
pp. 147-153 ◽  
Author(s):  
Kei-Ichi Hirai ◽  
Jie-Hong Pan ◽  
Ying-Bo Shui ◽  
Eriko Simamura ◽  
Hiroki Shimada ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Damage ◽  
Smooth Endoplasmic Reticulum ◽  
Dehydroascorbic Acid ◽  
Human Cells ◽  
Alpha Tocopherol ◽  
Cervical Cancer Cells ◽  
Cultured Human Cells ◽  
Nuclear Damage ◽  
Conjunctival Epithelial Cells

The possible protection of cultured human cells from acute dioxin injury by antioxidants was investigated. The most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), caused vacuolization of the smooth endoplasmic reticulum and Golgi apparatus in cultured human conjunctival epithelial cells and cervical cancer cells. Subsequent nuclear damage included a deep irregular indentation resulting in cell death. A dosage of 30–40 ng/mL TCDD induced maximal intracellular production of H2O2 at 30 minutes and led to severe cell death (0–31% survival) at two hours. A dose of 1.7 mM alpha-tocopherol or 1 mM L-dehydroascorbic acid significantly protected human cells against acute TCDD injuries (78–97% survivals), but vitamin C did not provide this protection. These results indicate that accidental exposure to fatal doses of TCDD causes cytoplasmic free radical production within the smooth endoplasmic reticular systems, resulting in severe cytotoxicity, and that vitamin E and dehydroascorbic acid can protect against TCDD-induced cell damage.

Sign in / Sign up

Export Citation Format

Share Document