ChemInform Abstract: Total Synthesis of Marine Natural Products Driven by Novel Structure, Potent Biological Activity, and/or Synthetic Methodology

ChemInform ◽  
2001 ◽  
Vol 32 (11) ◽  
pp. no-no
Author(s):  
D. Romo ◽  
R. M. Rzasa ◽  
W. D. Schmitz ◽  
J. Yang ◽  
S. T. Cohn ◽  
...  
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Total Synthesis ◽  
Marine Natural Products ◽  
Synthetic Methodology ◽  
Novel Structure

scholarly journals Marine-Derived Natural Lead Compound Disulfide-Linked Dimer Psammaplin A: Biological Activity and Structural Modification

Marine Drugs ◽  
2019 ◽  
Vol 17 (7) ◽  
pp. 384 ◽  
Author(s):  
Qinxue Jing ◽  
Xu Hu ◽  
Yanzi Ma ◽  
Jiahui Mu ◽  
Weiwei Liu ◽  
...  
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Total Synthesis ◽  
Marine Natural Products ◽  
Structural Modification ◽  
Research Focus ◽  
Chemical Structures ◽  
Therapeutic Drugs ◽  
Psammaplin A ◽  
Derivatives Of

Marine natural products are considered to be valuable resources that are furnished with diverse chemical structures and various bioactivities. To date, there are seven compounds derived from marine natural products which have been approved as therapeutic drugs by the U.S. Food and Drug Administration. Numerous bromotyrosine derivatives have been isolated as a type of marine natural products. Among them, psammaplin A, including the oxime groups and carbon–sulfur bonds, was the first identified symmetrical bromotyrosine-derived disulfide dimer. It has been found to have a broad bioactive spectrum, especially in terms of antimicrobial and antiproliferative activities. The highest potential indole-derived psammaplin A derivative, UVI5008, is used as an epigenetic modulator with multiple enzyme inhibitory activities. Inspired by these reasons, psammaplin A has gradually become a research focus for pharmacologists and chemists. To the best of our knowledge, there is no systematic review about the biological activity and structural modification of psammaplin A. In this review, the pharmacological effects, total synthesis, and synthesized derivatives of psammaplin A are summarized.

Total synthesis of marine natural products separacenes A and B

2017 ◽  
Vol 15 (22) ◽  
pp. 4842-4850 ◽  
Author(s):  
Subhendu Das ◽  
Rajib Kumar Goswami
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Marine Natural Products

Total synthesis of the potent antifungal agents bengazole C and E

2009 ◽  
Vol 74 (6) ◽  
pp. 887-900 ◽  
Author(s):  
Álvaro Enríquez-García ◽  
Steven V. Ley
Keyword(s):  
Natural Products ◽  
Antifungal Activity ◽  
Total Synthesis ◽  
Marine Natural Products ◽  
Antifungal Agents ◽  
Nitrile Oxide ◽  
Total Syntheses ◽  
Unique Structure

The bengazoles are marine natural products with unique structure, containing two oxazole rings flanking a single carbon. They show very potent antifungal activity. The total syntheses of bengazole C and E are described following a convergent route which involves diastereoselective cycloaddition of an appropriately substituted nitrile oxide with a butane-1,2-diacetal-protected alkenediol as the key step.

Total Synthesis of Natural Products and the Synergy with Synthetic Methodology

2012 ◽  
pp. 33-79
Author(s):  
Qian Wang ◽  
Jie-Ping Zhu ◽  
Kyriacos C. Nicolaou ◽  
Henry N. C. Wong ◽  
Wei-Dong Li
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Synthetic Methodology

ChemInform Abstract: MARINE NATURAL PRODUCTS FROM THE ATLANTIC ZONE. PART 27. TOTAL SYNTHESIS OF OBTUSENOL

1982 ◽  
Vol 13 (13) ◽  
Author(s):  
A. G. GONZALEZ ◽  
J. D. MARTIN ◽  
C. PEREZ ◽  
M. A. RAMIREZ ◽  
F. RAVELO
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Marine Natural Products
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