ChemInform Abstract: Effect of Acetophenone Derived Mannich Bases (I) on Cellular Glutathione Level in Jurkat Cells - A Possible Mechanism of Action.

ChemInform ◽  
2010 ◽  
Vol 32 (47) ◽  
pp. no-no
Author(s):  
Mustafa Gul ◽  
Halise Inci Gul ◽  
Jouko Vepsalainen ◽  
Ercin Erciyas ◽  
Osmo Hanninen
Keyword(s):  
Mechanism Of Action ◽  
Mannich Bases ◽  
Jurkat Cells ◽  
Glutathione Level

Effect of Acetophenone Derived Mannich Bases on Cellular Glutathione Level in Jurkat Cells

2011 ◽  
Vol 51 (08) ◽  
pp. 679-682 ◽  
Author(s):  
Mustafa Gul ◽  
Halise Gul ◽  
Jouko Vepsalainen ◽  
Ercin Erciyas ◽  
Osmo Hanninen
Keyword(s):  
Mannich Bases ◽  
Jurkat Cells ◽  
Glutathione Level

scholarly journals Octahydroquinoxalin-2(1H)-One-Based Aminophosphonic Acids and Their Derivatives—Biological Activity towards Cancer Cells

Materials ◽  
2020 ◽  
Vol 13 (10) ◽  
pp. 2393
Author(s):  
Jakub Iwanejko ◽  
Elżbieta Wojaczyńska ◽  
Eliza Turlej ◽  
Magdalena Maciejewska ◽  
Joanna Wietrzyk
Keyword(s):  
Cell Line ◽  
Mechanism Of Action ◽  
Caspase 3 ◽  
Antitumor Agents ◽  
Leukemia Cell ◽  
Mannich Bases ◽  
Leukemia Cell Line ◽  
Preliminary Evaluation ◽  
Aminophosphonic Acids ◽  
Low Cytotoxicity

In the search for new antitumor agents, aminophosphonic acids and their derivatives based on octahydroquinoxalin-2(1H)-one scaffold were obtained and their cytotoxic properties and a mechanism of action were evaluated. Phosphonic acid and phosphonate moieties increased the antiproliferative activity in comparison to phenolic Mannich bases previously reported. Most of the obtained compounds revealed a strong antiproliferative effect against leukemia cell line (MV-4-11) with simultaneous low cytotoxicity against normal cell line (mouse fibroblasts-BALB/3T3). The most active compound was diphenyl-[(1R,6R)-3-oxo-2,5-diazabicyclo[4.4.0]dec-4-yl]phosphonate. Preliminary evaluation of the mechanism of action showed the proapoptotic effect associated with caspase 3/7 induction.

Synthesis of some Mannich bases with dimethylamine and their hydrazones and evaluation of their cytotoxicity against Jurkat cells

2011 ◽  
Vol 61 (06) ◽  
pp. 366-371 ◽  
Author(s):  
Kaan Kucukoglu ◽  
Mustafa Gul ◽  
Mustafa Atalay ◽  
Ebru Mete ◽  
Cavit Kazaz ◽  
...  
Keyword(s):  
Mannich Bases ◽  
Jurkat Cells

scholarly journals Cytotoxicity of Some Azines of Acetophenone Derived Mono-Mannich Bases against Jurkat Cells

2003 ◽  
Vol 26 (5) ◽  
pp. 631-637 ◽  
Author(s):  
Halise Inci Gul ◽  
Mustafa Gul ◽  
Jouko Vepsälainen ◽  
Ercin Erciyas ◽  
Osmo Hänninen
Keyword(s):  
Mannich Bases ◽  
Jurkat Cells

The effects of some Mannich bases on heat shock proteins HSC70 and GRP75, and thioredoxin and glutaredoxin levels in Jurkat cells

2005 ◽  
Vol 19 (5) ◽  
pp. 573-580 ◽  
Author(s):  
Mustafa Gul ◽  
Mustafa Atalay ◽  
Halise Inci Gul ◽  
Chitose Nakao ◽  
Jani Lappalainen ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Mannich Bases ◽  
Jurkat Cells ◽  
Shock Proteins

Cytotoxic activities of mono and bis Mannich bases derived from acetophenone against Renca and Jurkat cells

2000 ◽  
Vol 74 (4) ◽  
pp. 393-398 ◽  
Author(s):  
H.Inci Gul ◽  
Jouko Vepsalainen ◽  
Mustafa Gul ◽  
Ercin Erciyas ◽  
Osmo Hanninen
Keyword(s):  
Mannich Bases ◽  
Jurkat Cells ◽  
Cytotoxic Activities
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