ChemInform Abstract: Reactivity of 4-Chlorobenzo[c][2,7]naphthyridines Towards Pd(0) Catalyzed Coupling Reactions and Nucleophilic Substitutions. Aroylation by Nucleophilic Substitution with Analogues of Acyl Anions.

ChemInform ◽  
2010 ◽  
Vol 33 (7) ◽  
pp. no-no
Author(s):  
G. Duvey ◽  
F. Nivoliers ◽  
P. Rocca ◽  
A. Godard ◽  
F. Marsais ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Coupling Reactions ◽  
Nucleophilic Substitutions

Organic Reactivity in Ionic Liquids: Some Mechanistic Insights into Nucleophilic Substitution Reactions

2005 ◽  
Vol 2005 (7) ◽  
pp. 413-417 ◽  
Author(s):  
N. Llewellyn Lancaster
Keyword(s):  
Ionic Liquids ◽  
Nucleophilic Substitution ◽  
Organic Reactions ◽  
Substitution Reactions ◽  
Nucleophilic Substitutions ◽  
Nucleophilic Substitution Reactions ◽  
Quantitative Studies ◽  
Alternative Solvents ◽  
Molecular Solvents ◽  
Organic Reactivity

Ionic liquids have been advanced as alternative solvents for organic reactions. In this paper, the principal findings of studies on nucleophilic substitutions in ionic liquids are reviewed. Thus our examination of halides (Cl-, Br- and I) in a range of ionic liquids is combined with our study of amine nucleophilicity into a single narrative. There have been a few other quantitative studies of nucleophilic substitutions in ionic liquids, and the results of these studies are also summarised in this work. These data are compared to related reactions in molecular solvents, and used to show where ionic liquids do (and do not) offer advantages over molecular solvents for nucleophilic substitutions.

scholarly journals Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains

2017 ◽  
Vol 13 ◽  
pp. 2115-2121 ◽  
Author(s):  
Layal Hariss ◽  
Kamal Bou Hadir ◽  
Mirvat El-Masri ◽  
Thierry Roisnel ◽  
René Grée ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Oxidative Coupling ◽  
Molecular Diversity ◽  
Side Chains ◽  
Coupling Reactions ◽  
Nucleophilic Substitutions ◽  
Heterocyclic Derivatives ◽  
Condensed Heterocycles

Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines. Condensed heterocycles of this type play an important role as key core structures of various bioactive compounds. Further, starting with a chloroimidazopyridazine derivative, Pd-catalyzed coupling reactions as well as nucleophilic substitutions have been performed successfully in order to increase the molecular diversity.

Copper-catalyzed synthesis of 2-aminophenyl benzothiazoles: a novel approach

2018 ◽  
Vol 16 (37) ◽  
pp. 8267-8272 ◽  
Author(s):  
S. N. Murthy Boddapati ◽  
Chandra Mohan Kurmarayuni ◽  
Baby Ramana Mutchu ◽  
Ramana Tamminana ◽  
Hari Babu Bollikolla
Keyword(s):  
Nucleophilic Substitution ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Reaction Conditions ◽  
Moderate Reaction ◽  
Cross Coupling Reactions ◽  
Novel Approach

Substituted 2-aminophenyl benzothiazoles have been constructed from thiourea via copper-catalyzed desulfurization/nucleophilic substitution followed by domino intra- and intermolecular C–N cross-coupling reactions under moderate reaction conditions.

Continuous flow solvent free organic synthesis involving solids (reactants/products) using a screw reactor

2019 ◽  
Vol 21 (20) ◽  
pp. 5639-5646 ◽  
Author(s):  
Brijesh M. Sharma ◽  
Ranjit S. Atapalkar ◽  
Amol A. Kulkarni
Keyword(s):  
Organic Synthesis ◽  
Continuous Flow ◽  
Aldol Condensation ◽  
Solvent Free ◽  
Coupling Reactions ◽  
Organic Transformations ◽  
Nucleophilic Substitutions ◽  
Screw Reactor

Various organic transformations such as aldol condensation, oxidation, nucleophilic substitutions, protection, acylations and coupling reactions are performed using a single mechanochemical platform.

Synthesis of aromatic functionalized cage-rearranged silsesquioxanes (T8, T10, and T12) via nucleophilic substitution reactions

2015 ◽  
Vol 44 (3) ◽  
pp. 916-919 ◽  
Author(s):  
Supansa Chimjarn ◽  
Rungthip Kunthom ◽  
Prapassorn Chancharone ◽  
Rapheepraew Sodkhomkhum ◽  
Preeyanuch Sangtrirutnugul ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Building Blocks ◽  
Polyhedral Oligomeric Silsesquioxanes ◽  
Substitution Reactions ◽  
Nucleophilic Substitutions ◽  
Inorganic Hybrid ◽  
Nucleophilic Substitution Reactions

Organic–inorganic hybrid nano-building blocks of aryl nitro-, aldehyde-, and bromo-functionalized polyhedral oligomeric silsesquioxanes (T8, T10, and T12) were easily prepared through nucleophilic substitutions.

Cytostatic 6-Arylpurine Nucleosides V. Synthesis of 8-Substituted 6-Phenylpurine Ribonucleosides

2003 ◽  
Vol 68 (5) ◽  
pp. 837-848 ◽  
Author(s):  
Michal Hocek ◽  
Dana Hocková ◽  
Jan Štambaský
Keyword(s):  
Phenylboronic Acid ◽  
Cross Coupling ◽  
Cytostatic Activity ◽  
Coupling Reactions ◽  
Nucleophilic Substitutions ◽  
Cross Coupling Reactions

Regioselective Suzuki-Miyaura reaction of 8-bromo-6-iodo-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine with phenylboronic acid gave 8-bromo-6-phenylpurine derivative that was used for cross-coupling reactions (with PhB(OH)2, Me3Al, Et3Al, BnZnCl) or nucleophilic substitutions (with NaOH, NaOMe, NH3, NHMe2 or thiourea). A series of 8-X-substituted 6-phenyl-9-(β-D-ribofuranosyl)purines (X = Ph, Me, Et, Bn, OH, OMe, NH2, NMe2, SH) was prepared in this way directly or after deprotection. None of the title nucleosides exhibited any considerable cytostatic activity.

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