Application of Tandem Ugi Reaction/Ring-Closing Metathesis in Multicomponent Synthesis of Unsaturated Nine-Membered Lactams.

ChemInform ◽  
2004 ◽  
Vol 35 (1) ◽  
Author(s):  
Luca Banfi ◽  
Andrea Basso ◽  
Giuseppe Guanti ◽  
Renata Riva
Keyword(s):  
Ugi Reaction ◽  
Multicomponent Synthesis ◽  
Ring Closing Metathesis

scholarly journals Ugi reaction-derived prolyl peptide catalysts grafted on the renewable polymer polyfurfuryl alcohol for applications in heterogeneous enamine catalysis

2019 ◽  
Vol 15 ◽  
pp. 1210-1216 ◽  
Author(s):  
Alexander F de la Torre ◽  
Gabriel S Scatena ◽  
Oscar Valdés ◽  
Daniel G Rivera ◽  
Márcio W Paixão
Keyword(s):  
Multicomponent Reactions ◽  
Supported Catalysts ◽  
Ugi Reaction ◽  
Multicomponent Synthesis ◽  
Polyfurfuryl Alcohol ◽  
Peptide Catalysts ◽  
Asymmetric Michael Addition ◽  
Enamine Catalysis ◽  
Work Supports ◽  
Peptide Catalyst

The multicomponent synthesis of prolyl pseudo-peptide catalysts using the Ugi reaction with furfurylamines or isocyanides is described. The incorporation of such a polymerizable furan handle enabled the subsequent polymerization of the peptide catalyst with furfuryl alcohol, thus rendering polyfurfuryl alcohol-supported catalysts for applications in heterogeneous enamine catalysis. The utilization of the polymer-supported catalysts in both batch and continuous-flow organocatalytic procedures proved moderate catalytic efficacy and enantioselectivity, but excellent diastereoselectivity in the asymmetric Michael addition of n-butanal to β-nitrostyrene that was used as a model reaction. This work supports the potential of multicomponent reactions towards the assembly of catalysts and their simultaneous functionalization for immobilization.

ChemInform Abstract: Multicomponent Synthesis of Cyclic Depsipeptide Mimics by Ugi Reaction Including Cyclic Hemiacetals Derived from Asymmetric Organocatalysis.

ChemInform ◽  
2016 ◽  
Vol 47 (25) ◽  
Author(s):  
Alexander F. de la Torre ◽  
Daniel G. Rivera ◽  
Odette Concepcion ◽  
Radell Echemendia ◽  
Arlene G. Correa ◽  
...  
Keyword(s):  
Ugi Reaction ◽  
Multicomponent Synthesis ◽  
Cyclic Depsipeptide ◽  
Asymmetric Organocatalysis

Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones

2011 ◽  
Vol 47 (24) ◽  
pp. 6966 ◽  
Author(s):  
Riccardo Mossetti ◽  
Tracey Pirali ◽  
Dèsirèe Saggiorato ◽  
Gian Cesare Tron
Keyword(s):  
Ugi Reaction ◽  
Multicomponent Synthesis ◽  
One Pot

ChemInform Abstract: Imides: Forgotten Players in the Ugi Reaction. One-Pot Multicomponent Synthesis of Quinazolinones.

ChemInform ◽  
2011 ◽  
Vol 42 (43) ◽  
pp. no-no
Author(s):  
Riccardo Mossetti ◽  
Tracey Pirali ◽  
Desiree Saggiorato ◽  
Gian Cesare Tron
Keyword(s):  
Ugi Reaction ◽  
Multicomponent Synthesis ◽  
One Pot

Multicomponent Synthesis of Cyclic Depsipeptide Mimics by Ugi Reaction Including Cyclic Hemiacetals Derived from Asymmetric Organocatalysis

2016 ◽  
Vol 81 (3) ◽  
pp. 803-809 ◽  
Author(s):  
Alexander F. de la Torre ◽  
Daniel G. Rivera ◽  
Odette Concepción ◽  
Radell Echemendia ◽  
Arlene G. Correa ◽  
...  
Keyword(s):  
Ugi Reaction ◽  
Multicomponent Synthesis ◽  
Cyclic Depsipeptide ◽  
Asymmetric Organocatalysis

scholarly journals Multicomponent synthesis of artificial nucleases and their RNase and DNase activity

2011 ◽  
Vol 7 ◽  
pp. 1135-1140 ◽  
Author(s):  
Anton V Gulevich ◽  
Lyudmila S Koroleva ◽  
Olga V Morozova ◽  
Valentina N Bakhvalova ◽  
Vladimir N Silnikov ◽  
...  
Keyword(s):  
Amino Acid ◽  
Nuclease Activity ◽  
Ugi Reaction ◽  
Amino Acid Residues ◽  
Multicomponent Synthesis ◽  
Artificial Ribonucleases ◽  
Circular Dna ◽  
Artificial Nucleases ◽  
Target Molecules ◽  
New Compounds

The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and double-stranded circular DNA.

Nickel-Catalyzed Inter- and Intramolecular Carbon-Sulfur Bond Metathesis by Reversible Arylation

2019 ◽  
Author(s):  
Tristan Delcaillau ◽  
Alessandro Bismuto ◽  
Zhong Lian ◽  
Bill Morandi
Keyword(s):  
Good Yield ◽  
Functional Group ◽  
Product Formation ◽  
Single Bond ◽  
Ring Closing Metathesis ◽  
Catalytic Systems ◽  
Metathesis Reactions ◽  
New Applications ◽  
Further Development ◽  
Sulfur Bond

A nickel-catalyzed carbon-sulfur bond metathesis has been developed to access high-value thioethers. 1,2-bis(dicyclohexylphosphino)ethane (dcype) is essential to promote this highly functional group tolerant reaction. Further, synthetically challenging macrocycles could be obtained in good yield in an unusual example of ring-closing metathesis which does not involve alkene bonds. In-depth organometallic studies support a reversible Ni(0)-Ni(II) pathway to product formation. Overall, this work does not only disclose a more sustainable and more functional group tolerant alternative to previous catalytic systems based on Pd, but also presents new applications and mechanistic information which are highly relevant to the further development and application of unusual single bond metathesis reactions.

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