Synthesis and SAR Studies of 4-(Heteroarylpiperidin-1-yl-methyl)-pyrrolidin-1-yl-acetic Acid Antagonists of the Human CCR5 Chemokine Receptor.

K. Shankaran; et al. et al.

doi:10.1002/chin.200442159

Synthesis and SAR Studies of 4-(Heteroarylpiperidin-1-yl-methyl)-pyrrolidin-1-yl-acetic Acid Antagonists of the Human CCR5 Chemokine Receptor.

ChemInform ◽

10.1002/chin.200442159 ◽

2004 ◽

Vol 35 (42) ◽

Author(s):

K. Shankaran ◽

et al. et al.

Keyword(s):

Acetic Acid ◽

Chemokine Receptor ◽

Ccr5 Chemokine Receptor ◽

Sar Studies ◽

Human Ccr5

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Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(04)00593-1 ◽

2004 ◽

Author(s):

K SHANKARAN

Keyword(s):

Acetic Acid ◽

Chemokine Receptor ◽

Ccr5 Chemokine Receptor ◽

Sar Studies ◽

Human Ccr5

Download Full-text

Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.04.078 ◽

2004 ◽

Vol 14 (13) ◽

pp. 3419-3424 ◽

Cited By ~ 15

Author(s):

K. Shankaran ◽

Karla L. Donnelly ◽

Shrenik K. Shah ◽

Ravindra N. Guthikonda ◽

Malcolm MacCoss ◽

...

Keyword(s):

Acetic Acid ◽

Chemokine Receptor ◽

Ccr5 Chemokine Receptor ◽

Sar Studies ◽

Human Ccr5

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Investigation of the Structural Requirement for Blocking the Human CCR5 Chemokine Receptor. An Insight from Quantitative Structure Activity Relationships Study

Letters in Drug Design & Discovery ◽

10.2174/157018009787582615 ◽

2009 ◽

Vol 6 (2) ◽

pp. 114-124 ◽

Cited By ~ 1

Author(s):

Nigus Dessalew

Keyword(s):

Chemokine Receptor ◽

Quantitative Structure ◽

Structural Requirement ◽

Ccr5 Chemokine Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Human Ccr5

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Structure prediction of GPCRs using piecewise homologs and application to the human CCR5 chemokine receptor: validation through agonist and antagonist docking

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2013.817952 ◽

2013 ◽

Vol 32 (8) ◽

pp. 1274-1289 ◽

Cited By ~ 9

Author(s):

Karthik Arumugam ◽

Serge Crouzy ◽

Andy Chevigne ◽

Carole Seguin-Devaux ◽

Jean-Claude Schmit

Keyword(s):

Chemokine Receptor ◽

Structure Prediction ◽

Ccr5 Chemokine Receptor ◽

Agonist And Antagonist ◽

Human Ccr5

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Modeling the Structural Basis of Human CCR5 Chemokine Receptor Function: From Homology Model Building and Molecular Dynamics Validation to Agonist and Antagonist Docking.

ChemInform ◽

10.1002/chin.200630234 ◽

2006 ◽

Vol 37 (30) ◽

Author(s):

A. Fano ◽

D. W. Ritchie ◽

A. Carrieri

Keyword(s):

Molecular Dynamics ◽

Chemokine Receptor ◽

Model Building ◽

Homology Model ◽

Structural Basis ◽

Receptor Function ◽

Ccr5 Chemokine Receptor ◽

Agonist And Antagonist ◽

Human Ccr5

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Modeling the Structural Basis of Human CCR5 Chemokine Receptor Function: From Homology Model Building and Molecular Dynamics Validation to Agonist and Antagonist Docking

Journal of Chemical Information and Modeling ◽

10.1021/ci050490k ◽

2006 ◽

Vol 46 (3) ◽

pp. 1223-1235 ◽

Cited By ~ 28

Author(s):

A. Fano ◽

D. W. Ritchie ◽

A. Carrieri

Keyword(s):

Molecular Dynamics ◽

Chemokine Receptor ◽

Model Building ◽

Homology Model ◽

Structural Basis ◽

Receptor Function ◽

Ccr5 Chemokine Receptor ◽

Agonist And Antagonist ◽

Human Ccr5

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Faculty Opinions recommendation of Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718106759.793484827 ◽

2013 ◽

Author(s):

Dimitrios Morikis

Keyword(s):

Chemokine Receptor ◽

Entry Inhibitor ◽

Ccr5 Chemokine Receptor ◽

Hiv Entry

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The dual CCR2/CCR5 chemokine receptor antagonist Cenicriviroc reduces macrophage infiltration and disease severity in Duchenne muscular dystrophy (Dmdmdx-4Cv) mice

PLoS ONE ◽

10.1371/journal.pone.0194421 ◽

2018 ◽

Vol 13 (3) ◽

pp. e0194421 ◽

Cited By ~ 10

Author(s):

Feng Liang ◽

Christian Giordano ◽

Dong Shang ◽

Qian Li ◽

Basil J. Petrof

Keyword(s):

Duchenne Muscular Dystrophy ◽

Muscular Dystrophy ◽

Receptor Antagonist ◽

Disease Severity ◽

Chemokine Receptor ◽

Macrophage Infiltration ◽

Ccr5 Chemokine Receptor ◽

Chemokine Receptor Antagonist

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Response: To force the expression of CCR4 and/or of CCR5 chemokine receptor in T cells for immunotherapy of Hodgkin lymphoma: that is the question

Blood ◽

10.1182/blood-2009-11-248302 ◽

2010 ◽

Vol 115 (3) ◽

pp. 748-748 ◽

Cited By ~ 1

Author(s):

Gianpietro Dotti ◽

Barbara Savoldo

Keyword(s):

T Cells ◽

Hodgkin Lymphoma ◽

Chemokine Receptor ◽

Ccr5 Chemokine Receptor

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4,4-Disubstituted cyclohexylamine based CCR5 chemokine receptor antagonists as anti-HIV-1 agents

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.07.074 ◽

2009 ◽

Vol 19 (17) ◽

pp. 4988-4992 ◽

Cited By ~ 8

Author(s):

Maosheng Duan ◽

Christopher Aquino ◽

George F. Dorsey ◽

Robert Ferris ◽

Wieslaw M. Kazmierski

Keyword(s):

Chemokine Receptor ◽

Receptor Antagonists ◽

Ccr5 Chemokine Receptor ◽

Anti Hiv ◽

Hiv 1

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