Faculty Opinions recommendation of Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex.

2013 ◽  
Author(s):  
Dimitrios Morikis
Keyword(s):  
Chemokine Receptor ◽  
Entry Inhibitor ◽  
Ccr5 Chemokine Receptor ◽  
Hiv Entry

scholarly journals Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

Science ◽  
2013 ◽  
Vol 341 (6152) ◽  
pp. 1387-1390 ◽  
Author(s):  
Q. Tan ◽  
Y. Zhu ◽  
J. Li ◽  
Z. Chen ◽  
G. W. Han ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Entry Inhibitor ◽  
Ccr5 Chemokine Receptor ◽  
Hiv Entry

Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA)

2005 ◽  
Vol 67 (2) ◽  
pp. 83-92 ◽  
Author(s):  
Maria T. Polianova ◽  
Francis W. Ruscetti ◽  
Candace B. Pert ◽  
Michael R. Ruff
Keyword(s):  
Chemokine Receptor ◽  
Entry Inhibitor ◽  
Peptide T ◽  
Inhibitor Peptide ◽  
Hiv Entry ◽  
Chemokine Receptor 5

scholarly journals Prevention and treatment of SHIVAD8 infection in rhesus macaques by a potent d-peptide HIV entry inhibitor

2020 ◽  
Vol 117 (36) ◽  
pp. 22436-22442
Author(s):  
Yoshiaki Nishimura ◽  
J. Nicholas Francis ◽  
Olivia K. Donau ◽  
Eric Jesteadt ◽  
Reza Sadjadpour ◽  
...  
Keyword(s):  
Rhesus Macaques ◽  
Entry Inhibitor ◽  
High Dose ◽  
Combination Antiretroviral Therapy ◽  
Promising Candidate ◽  
Macaque Model ◽  
Prevention And Treatment ◽  
Hiv Entry ◽  
Virus Isolates ◽  
Primary Virus

Cholesterol-PIE12-trimer (CPT31) is a potentd-peptide HIV entry inhibitor that targets the highly conserved gp41 N-peptide pocket region. CPT31 exhibited strong inhibitory breadth against diverse panels of primary virus isolates. In a simian-HIV chimeric virus AD8 (SHIVAD8) macaque model, CPT31 prevented infection from a single high-dose rectal challenge. In chronically infected animals, CPT31 monotherapy rapidly reduced viral load by ∼2 logs before rebound occurred due to the emergence of drug resistance. In chronically infected animals with viremia initially controlled by combination antiretroviral therapy (cART), CPT31 monotherapy prevented viral rebound after discontinuation of cART. These data establish CPT31 as a promising candidate for HIV prevention and treatment.

4,4-Disubstituted cyclohexylamine based CCR5 chemokine receptor antagonists as anti-HIV-1 agents

2009 ◽  
Vol 19 (17) ◽  
pp. 4988-4992 ◽  
Author(s):  
Maosheng Duan ◽  
Christopher Aquino ◽  
George F. Dorsey ◽  
Robert Ferris ◽  
Wieslaw M. Kazmierski
Keyword(s):  
Chemokine Receptor ◽  
Receptor Antagonists ◽  
Ccr5 Chemokine Receptor ◽  
Anti Hiv ◽  
Hiv 1

CCR5 chemokine receptor gene evolution in New World monkeys (Platyrrhini, Primates): implication on resistance to lentiviruses

2005 ◽  
Vol 5 (3) ◽  
pp. 271-280 ◽  
Author(s):  
Ieda P. Ribeiro ◽  
Carlos G. Schrago ◽  
Esmeralda A. Soares ◽  
Alcides Pissinatti ◽  
Hector N. Seuanez ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
New World ◽  
Gene Evolution ◽  
Receptor Gene ◽  
New World Monkeys ◽  
Ccr5 Chemokine Receptor ◽  
Chemokine Receptor Gene
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