scholarly journals High-Yield Solution-Phase Synthesis of Di- and Trinucleotide Blocks Assisted by Polymer-Supported Reagents.

ChemInform ◽  
2005 ◽  
Vol 36 (44) ◽  
Author(s):  
Cecile Dueymes ◽  
Andreas Schoenberger ◽  
Ilaria Adamo ◽  
Aude-Emmanuelle Navarro ◽  
Albert Meyer ◽  
...  
Keyword(s):  
Solution Phase ◽  
High Yield ◽  
Phase Synthesis ◽  
Solution Phase Synthesis ◽  
Polymer Supported

High-Yield Solution-Phase Synthesis of Di- and Trinucleotide Blocks Assisted by Polymer-Supported Reagents

2005 ◽  
Vol 7 (16) ◽  
pp. 3485-3488 ◽  
Author(s):  
Cécile Dueymes ◽  
Andreas Schönberger ◽  
Ilaria Adamo ◽  
Aude-Emmanuelle Navarro ◽  
Albert Meyer ◽  
...  
Keyword(s):  
Solution Phase ◽  
High Yield ◽  
Phase Synthesis ◽  
Solution Phase Synthesis ◽  
Polymer Supported

Synthesis of O-Phosphotyrosine-Containing Peptides. II. Solution-Phase Synthesis of Asn-Glu-PTyr-Thr-Ala Through Methyl Phosphate Protection

1989 ◽  
Vol 42 (9) ◽  
pp. 1519 ◽  
Author(s):  
RM Valerio ◽  
JW Perich ◽  
EA Kitas ◽  
PF Alewood ◽  
RB Johns
Keyword(s):  
Trifluoroacetic Acid ◽  
Dimethyl Sulfide ◽  
Solution Phase ◽  
High Yield ◽  
Phase Synthesis ◽  
Rous Sarcoma ◽  
Naturally Occurring ◽  
Solution Phase Synthesis ◽  
Sarcoma Virus ◽  
Methyl Phosphate

The PTyr (O-phosphotyrosine) pentapeptide H-Asn-Glu-Tyr(PO3H2)-Thr-Ala-OH.HO2CCF3, which is a naturally occurring sequence from the autophosphorylated Rous sarcoma virus pp60V-SrC, was prepared in high yield by the use of Boc-Tyr(PO3Me2)-OH in the Boc mode of solution-phase peptide synthesis. The protected pentapeptide, Z-Asn-Glu(OBzl)-Tyr(PO3Me2)-Thr(Bzl)-Ala-OBzl, was deprotected by a two-stage procedure which involved initial palladium-catalysed hydrogenolysis followed by the removal of the phosphate methyl groups by the use of one of the following treatments: (A) 10% bromotrimethylsilane/acetonitrile, (B) 1 M bromotrimethylsilane/thioanisole in trifluoroacetic acid, or (C) trifluoromethanesulfonic acid/trifluoroacetic acid/dimethyl sulfide/m-cresol.

Solution Phase Synthesis and Conformational Analysis of Glu-Ser-Leu-Ser-Ser-Ser-Glu-Glu-NHMe and Its Peptide Congeners (Non-Phosphorylated Region 14-21 of Bovine β-Casein A2)

1992 ◽  
Vol 45 (11) ◽  
pp. 1857 ◽  
Author(s):  
JW Perich ◽  
RB Johns
Keyword(s):  
Conformational Analysis ◽  
Peptide Synthesis ◽  
Reversed Phase ◽  
Solution Phase ◽  
High Yield ◽  
Reversed Phase Chromatography ◽  
Phase Synthesis ◽  
Solution Phase Synthesis ◽  
Yield And Purity ◽  
Protected Peptides

The octapeptide H-Glu-Ser-Leu-Ser-Ser-Ser-Glu-Glu-NHMe.CF3CO2H and its five shorter peptide congeners (from tripeptide to heptapeptide ) were prepared in high yield and purity by the Boc mode of solution phase peptide synthesis followed by palladium- catalysed hydrogenolytic deprotection of the six protected peptides in 50% CF3CO2H/CH3CO2H solution. The analysis of the six peptides by 13C n.m.r. spectroscopy and C18 reversed-phase chromatography suggested that a structural arrangement commenced at the hexapeptide stage and was considered to be due to the formation of a β-turn conformation.

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