Solution Phase Synthesis and Conformational Analysis of Glu-Ser-Leu-Ser-Ser-Ser-Glu-Glu-NHMe and Its Peptide Congeners (Non-Phosphorylated Region 14-21 of Bovine β-Casein A2)

1992 ◽  
Vol 45 (11) ◽  
pp. 1857 ◽  
Author(s):  
JW Perich ◽  
RB Johns
Keyword(s):  
Conformational Analysis ◽  
Peptide Synthesis ◽  
Reversed Phase ◽  
Solution Phase ◽  
High Yield ◽  
Reversed Phase Chromatography ◽  
Phase Synthesis ◽  
Solution Phase Synthesis ◽  
Yield And Purity ◽  
Protected Peptides

The octapeptide H-Glu-Ser-Leu-Ser-Ser-Ser-Glu-Glu-NHMe.CF3CO2H and its five shorter peptide congeners (from tripeptide to heptapeptide ) were prepared in high yield and purity by the Boc mode of solution phase peptide synthesis followed by palladium- catalysed hydrogenolytic deprotection of the six protected peptides in 50% CF3CO2H/CH3CO2H solution. The analysis of the six peptides by 13C n.m.r. spectroscopy and C18 reversed-phase chromatography suggested that a structural arrangement commenced at the hexapeptide stage and was considered to be due to the formation of a β-turn conformation.

Synthesis of O-Phosphotyrosine-Containing Peptides. II. Solution-Phase Synthesis of Asn-Glu-PTyr-Thr-Ala Through Methyl Phosphate Protection

1989 ◽  
Vol 42 (9) ◽  
pp. 1519 ◽  
Author(s):  
RM Valerio ◽  
JW Perich ◽  
EA Kitas ◽  
PF Alewood ◽  
RB Johns
Keyword(s):  
Trifluoroacetic Acid ◽  
Dimethyl Sulfide ◽  
Solution Phase ◽  
High Yield ◽  
Phase Synthesis ◽  
Rous Sarcoma ◽  
Naturally Occurring ◽  
Solution Phase Synthesis ◽  
Sarcoma Virus ◽  
Methyl Phosphate

The PTyr (O-phosphotyrosine) pentapeptide H-Asn-Glu-Tyr(PO3H2)-Thr-Ala-OH.HO2CCF3, which is a naturally occurring sequence from the autophosphorylated Rous sarcoma virus pp60V-SrC, was prepared in high yield by the use of Boc-Tyr(PO3Me2)-OH in the Boc mode of solution-phase peptide synthesis. The protected pentapeptide, Z-Asn-Glu(OBzl)-Tyr(PO3Me2)-Thr(Bzl)-Ala-OBzl, was deprotected by a two-stage procedure which involved initial palladium-catalysed hydrogenolysis followed by the removal of the phosphate methyl groups by the use of one of the following treatments: (A) 10% bromotrimethylsilane/acetonitrile, (B) 1 M bromotrimethylsilane/thioanisole in trifluoroacetic acid, or (C) trifluoromethanesulfonic acid/trifluoroacetic acid/dimethyl sulfide/m-cresol.

scholarly journals High-Yield Solution-Phase Synthesis of Di- and Trinucleotide Blocks Assisted by Polymer-Supported Reagents.

ChemInform ◽  
2005 ◽  
Vol 36 (44) ◽  
Author(s):  
Cecile Dueymes ◽  
Andreas Schoenberger ◽  
Ilaria Adamo ◽  
Aude-Emmanuelle Navarro ◽  
Albert Meyer ◽  
...  
Keyword(s):  
Solution Phase ◽  
High Yield ◽  
Phase Synthesis ◽  
Solution Phase Synthesis ◽  
Polymer Supported

High-Yield Solution-Phase Synthesis of Di- and Trinucleotide Blocks Assisted by Polymer-Supported Reagents

2005 ◽  
Vol 7 (16) ◽  
pp. 3485-3488 ◽  
Author(s):  
Cécile Dueymes ◽  
Andreas Schönberger ◽  
Ilaria Adamo ◽  
Aude-Emmanuelle Navarro ◽  
Albert Meyer ◽  
...  
Keyword(s):  
Solution Phase ◽  
High Yield ◽  
Phase Synthesis ◽  
Solution Phase Synthesis ◽  
Polymer Supported

A Low Temperature, Solution Phase Synthesis of III-V Semiconductor Nanocrystals

1994 ◽  
Vol 351 ◽  
Author(s):  
Shreyas S. Kher ◽  
Richard L. Wells
Keyword(s):  
Semiconductor Nanocrystals ◽  
Solution Phase ◽  
High Yield ◽  
Group V ◽  
Phase Synthesis ◽  
Group Iii ◽  
Wide Range ◽  
Solution Phase Synthesis ◽  
Temperature Solution ◽  
High Yields

ABSTRACTNanocrystalline materials have been intensely investigated in the recent past due to the novel properties associated with size-quantized particles. We have developed a new method for high yield, solution phase synthesis of nanocrystalline III-V semiconductors which eliminates the use of substituted or unsubstituted Group V hydrides and Group III alkyls. Our approach consists of in situ syntheses of (Na/K)3E (E = P, As, Sb) in aromatic solvents and subsequent reactions of these pnictides with Group III halide solutions in coordinating solvents. The nanocrystalline III-V semiconductors GaP, GaAs, GaSb, InP, InAs and InSb are readily prepared in a wide range of particle sizes (4–36 nm) and in high yields. The resultant Ill-V materials have been characterized by XRD, EDXA, TEM and elemental analyses.

Solution-Phase Peptide Synthesis; Synthesis of 'North-Western' and 'South-Eastern' Fragments of the Antifungal Cyclodepsipeptide Petriellin A

2008 ◽  
Vol 61 (8) ◽  
pp. 615 ◽  
Author(s):  
Luigi Aurelio ◽  
Robert T. C. Brownlee ◽  
Andrew B. Hughes
Keyword(s):  
Peptide Synthesis ◽  
Solution Phase ◽  
Phase Synthesis ◽  
South Eastern ◽  
Cyclic Depsipeptide ◽  
Solution Phase Synthesis ◽  
Modified Peptides ◽  
North Western

The solution-phase synthesis of two highly modified peptides, a hexamer and a heptamer, that constitute the two halves of the antifungal cyclic depsipeptide, Petriellin A, is reported.

Rapid and high-yield solution-phase synthesis of DOTA-Tyr3-octreotide and DOTA-Tyr3-octreotate using unprotected DOTA

2003 ◽  
Vol 44 (11) ◽  
pp. 2393-2396 ◽  
Author(s):  
Margret Schottelius ◽  
Markus Schwaiger ◽  
Hans-Jürgen Wester
Keyword(s):  
Solution Phase ◽  
High Yield ◽  
Phase Synthesis ◽  
Solution Phase Synthesis

scholarly journals Solution-phase-peptide synthesis via the group-assisted purification (GAP) chemistry without using chromatography and recrystallization

2014 ◽  
Vol 50 (10) ◽  
pp. 1259-1261 ◽  
Author(s):  
Jianbin Wu ◽  
Guanghui An ◽  
Siqi Lin ◽  
Jianbo Xie ◽  
Wei Zhou ◽  
...  
Keyword(s):  
Amino Acids ◽  
Liquid Phase ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Environmentally Friendly ◽  
Solution Phase ◽  
Silica Gels ◽  
Phase Synthesis ◽  
Solution Phase Synthesis

The solution phase synthesis of N-protected amino acids and peptides has been achieved through GAP chemistry by avoiding disadvantages of the solid-phase-peptide synthesis (SPPS) and liquid-phase-peptide synthesis. The environmentally friendly GAP synthesis can substantially reduce the use of solvents, silica gels, energy and manpower.

Solution phase synthesis of oligonucleotides by the phosphoramidite method using solid supported reagents

2005 ◽  
Author(s):  
François Morvan ◽  
Aude-Emmanuelle Navarro ◽  
Cécile Dueymes ◽  
Ilaria Adamo ◽  
Andreas Schoenberger ◽  
...  
Keyword(s):  
Solution Phase ◽  
Phase Synthesis ◽  
Solution Phase Synthesis
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