N-Thiolated 2-Oxazolidinones: A New Family of Antibacterial Agents for Methicillin-Resistant Staphylococcus aureus and Bacillus anthracis.

Purpose. This study describes the antibacterial effect of extracts and compounds isolated from the aerial part of Chelidonium majus Linn. (Papaveraceae) acting against clinical strains of methicillin-resistant Staphylococcus aureus (MRSA). Methods. The activities were evaluated by using the macrobroth dilution method and reported as the MICs/MBCs. Results. Bioassay-guided fractionation of the most active extract from the aerial parts (EtOAc) led to the isolation of benzo[c]phenanthridine-type alkaloids 8-hydroxydihydrosanguinarine (hhS), 8-hydroxydihydrochelerythrine (hhC), which were potently active against MRSA strains. Conclusions. The selective antibacterial activity reported in this paper for 8-hydroxylated benzo[c]phenanthridine-type alkaloids isolated from C.majus opens the possibility that they could be helpful for the developing of new antibacterial agents for treating the infection of MRSA which has created nosocomial problem worldwide.

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In vitro synergism of magnolol and honokiol in combination with antibacterial agents against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA)

BMC Complementary and Alternative Medicine ◽

10.1186/s12906-015-0938-3 ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 9

Author(s):

Guo-Ying Zuo ◽

Xin-Juan Zhang ◽

Jun Han ◽

Yu-Qing Li ◽

Gen-Chun Wang

Keyword(s):

Staphylococcus Aureus ◽

Antibacterial Agents ◽

Methicillin Resistant Staphylococcus Aureus ◽

Clinical Isolates ◽

Methicillin Resistant

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Mullein and red clover extracts are effective antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and four skin and soft tissue infection (SSTI)-associated bacteria

BIOS ◽

10.1893/bios-d-18-00027 ◽

2020 ◽

Vol 91 (1) ◽

pp. 42

Author(s):

Courtney N. Shade ◽

Kisun Peters-Diaz ◽

Sarah E. Ruffell

Keyword(s):

Staphylococcus Aureus ◽

Soft Tissue ◽

Soft Tissue Infection ◽

Antibacterial Agents ◽

Methicillin Resistant Staphylococcus Aureus ◽

Red Clover ◽

Tissue Infection ◽

Associated Bacteria ◽

Methicillin Resistant

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ComparativeIn VitroActivities of Oritavancin, Dalbavancin, and Vancomycin against Methicillin-Resistant Staphylococcus aureus Isolates in a Nondividing State

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00169-16 ◽

2016 ◽

Vol 60 (7) ◽

pp. 4342-4345 ◽

Cited By ~ 8

Author(s):

Adam Belley ◽

David Lalonde Seguin ◽

Francis Arhin ◽

Greg Moeck

Keyword(s):

Staphylococcus Aureus ◽

Bactericidal Activity ◽

Antibacterial Agents ◽

Methicillin Resistant Staphylococcus Aureus ◽

Methicillin Resistant ◽

Content Type ◽

Skin Structure ◽

Persistent Infections ◽

Time Kill

ABSTRACTAntibacterial agents that kill nondividing bacteria may be of utility in treating persistent infections. Oritavancin and dalbavancin are bactericidal lipoglycopeptides that are approved for acute bacterial skin and skin structure infections in adults caused by susceptible Gram-positive pathogens. Using time-kill methodology, we demonstrate that oritavancin exerts bactericidal activity against methicillin-resistantStaphylococcus aureus(MRSA) isolates that are maintained in a nondividing statein vitro, whereas dalbavancin and the glycopeptide vancomycin do not.

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