ChemInform Abstract: DCC-Celite Hybrid Immobilized Solid Support as a New, Highly Efficient Reagent for the Synthesis of O-Alkyl Hydrogen Alkylphosphonates under Solvent-Free Conditions.
Abstract
A highly efficient and green protocol for the synthesis of pyrimido[4,5-b]quinolines has been described. The one-pot multicomponent reaction of dimedone with arylaldehydes and 6-amino-1,3-dimethyluracil in the presence of N,N-diethyl-N-sulfoethanaminium chloride ([Et3N–SO3H][Cl]) as an ionic liquid (IL) catalyst under solvent-free conditions afforded the mentioned compounds in high yields and short reaction times. Our protocol is superior to many of the reported protocols in terms of two or more of these factors: the reaction times, yields, conditions (solvent-free versus usage of organic solvents), temperature and catalyst amount.
This work provides a highly efficient and feasible strategy for the synthesis of symmetric methylene diesters, involving the direct diesterification of various carboxylates with 1,n-dihaloalkanes under solvent-free conditions.
A highly efficient way for the direct (trans)esterification of acyl acids (esters) and alcohols in a strict 1 : 1 ratio using a zirconocene complex (1, 1 mol%), a strong Lewis acid of good water tolerance, as a catalyst under solvent-free conditions has been developed.
An efficient three-component, catalyst-, solvent-, and column chromatography-free procedure was developed for the synthesis of 3-(1H-pyrrol-3-yl)indolin-2-ones.
Solvent-free synthesis of symmetric methylene diesters via direct reaction of aromatic carboxylates with 1,n-dihaloalkanes