ChemInform Abstract: One-Pot Three Components Synthesis of O-Acetylcyanohydrins with TMSCN, Acetic Anhydride and Carbonyl Compounds under Solvent-Free Condition.
A highly efficient and improved synthetic methodology for the preparation of 3,4-dihydropyrimidin-2(1H)-one derivatives in good to excellent yield via Biginelli reaction of β-ketoesters/β-diketone, urea/thiourea and various aldehydes using new, efficient and recyclable sulfated polyborate catalyst under the solvent-free condition is reported.