A new procedure for the preparation of 3,4-dihydropyrimidin-2(1H)-one and octahydroquinazolinone derivatives catalyzed by SCMNPs@CA-EA-SO3H under solvent-free conditions

Catalyzed with SCMNPs@CA-EA-SO3H, as a green and heterogeneous solid acid catalyst, 3,4-dihydropyrimidin-2(1H)-one and octahydroquinazolinone derivatives were obtained in high-to-excellent yields and in short reaction times via the one-pot multi-component condensation of ethyl acetoacetate or dimedone, urea, and aldehyde compounds under solvent-free conditions. More importantly, the green catalytic system could be easily collected from the reaction solution utilizing an external magnet and reused for five runs with a negligible decrease in yields and reaction rate.

An Efficient Multicomponent Synthesis of Octahydroquinazolinone Derivatives Using Novel Recyclable Grafted Fe APA-Complex Catalyst

Recoverable and recyclable heterogeneous grafted Fe-APA complex efficiently catalyzed the one-pot synthesis of octahydroquinazolinone derivatives via multicomponent reaction of dimedone, aromatic aldehyde, and urea using methanol as a solvent. The desired products were obtained with 84–96 % yields. The present approach offers several significants such as short reaction time, high yield, easy purification, minimum catalyst loading, and use as an alternative catalyst. Grafted Fe APA complex were synthesized and characterized by various analytical investigative techniques like FTIR, NMR, Mass, XRD, SEM, EDAX, TEM with SAED, and BET surface area.