ChemInform Abstract: Total Synthesis of (+)-Scyphostatin Featuring an Enantioselective and Highly Efficient Route to the Side-Chain via Zr-Catalyzed Asymmetric Carboalumination of Alkenes (ZACA).

ChemInform ◽  
2010 ◽  
Vol 41 (32) ◽  
pp. no-no
Author(s):  
Emmanuel Pitsinos ◽  
Nikolaos Athinaios ◽  
Zhaoqing Xu ◽  
Guangwei Wang ◽  
Ei-ichi Negishi
Keyword(s):  
Total Synthesis ◽  
Side Chain ◽  
Highly Efficient ◽  
Efficient Route

Total synthesis of (+)-scyphostatin featuring an enantioselective and highly efficient route to the side-chain via Zr-catalyzed asymmetric carboalumination of alkenes (ZACA)

2010 ◽  
Vol 46 (13) ◽  
pp. 2200 ◽  
Author(s):  
Emmanuel Pitsinos ◽  
Nikolaos Athinaios ◽  
Zhaoqing Xu ◽  
Guangwei Wang ◽  
Ei-ichi Negishi
Keyword(s):  
Total Synthesis ◽  
Side Chain ◽  
Highly Efficient ◽  
Efficient Route

A Ruthenium-Catalyzed C–H Activation Strategy as an Efficient Shortcut in the Total Synthesis of 6,8-Dimethoxy-1,3-dimethyl­isoquinoline

Synthesis ◽  
2019 ◽  
Vol 51 (20) ◽  
pp. 3908-3914
Author(s):  
Santiago Fonzo ◽  
Didier F. Vargas ◽  
Teodoro S. Kaufman
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Side Chain ◽  
One Pot ◽  
Microwave Assisted ◽  
Efficient Route ◽  
Carbon Side Chain

A short and convenient total synthesis of 6,8-dimethoxy-1,3-dimethylisoquinoline, employing a C–H activation/alkenylation strategy, is reported. The approach involves the CeCl3·7H2O-promoted methoximation of 2,4-dimethoxyacetophenone and a methoxime-directed ruthenium-catalyzed allylation. This was followed by a one-pot, ruthenium-catalyzed allyl to propenyl isomerization and a microwave-assisted 6π-azaelectrocylization to complete the sequence. This approach, which entails a shortcut in the synthetic management of the three-carbon side chain, is an improved and more efficient route toward the natural product, which facilitated its access in just three steps and 27.3% overall yield.

New Dithiazole Side Chain Benzodithiophene Containing D–A Copolymers for Highly Efficient Nonfullerene Solar Cells

2021 ◽  
pp. 2100053
Author(s):  
Muhammed L. Keshtov ◽  
Ionv O. Konstantinov ◽  
ILya E. Ostapov ◽  
Alexei R. Khokhlov ◽  
Vladimir G. Alekseev ◽  
...  
Keyword(s):  
Solar Cells ◽  
Side Chain ◽  
Highly Efficient

ChemInform Abstract: Total Synthesis of a New 7-Deoxyidarubicinone Derivative Through the Functionalization of an A-Ring Side Chain.

ChemInform ◽  
2000 ◽  
Vol 31 (49) ◽  
pp. no-no
Author(s):  
Young S. Rho ◽  
Hyun Kyoung Ko ◽  
Wan-Joong Kim ◽  
Dong Jin Yoo ◽  
Heun Soo Kang
Keyword(s):  
Total Synthesis ◽  
Side Chain

Direct-write printing of reactive oligomeric alkoxysilanes as an affordable and highly efficient route for promoting local adhesion of silver inks on polymer substrates

2016 ◽  
Vol 4 (11) ◽  
pp. 2211-2218 ◽  
Author(s):  
Marina N. Kirikova ◽  
Elena V. Agina ◽  
Alexander A. Bessonov ◽  
Alexey S. Sizov ◽  
Oleg V. Borshchev ◽  
...  
Keyword(s):  
Direct Write ◽  
Polymer Substrates ◽  
Highly Efficient ◽  
Novel Approach ◽  
Efficient Route ◽  
Polymeric Substrates

A novel approach for improving the printability and adhesion of silver inks on flexible and stretchable polymeric substrates is reported.

scholarly journals Stereocontrolled total synthesis of (+)-vinblastine

2003 ◽  
Vol 75 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Satoshi Yokoshima ◽  
T. Ueda ◽  
S. Kobayashi ◽  
A. Sato ◽  
Takeshi Kuboyama ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Coupling Reaction ◽  
Radical Cyclization ◽  
Critical Coupling ◽  
Efficient Manner ◽  
Complete Control ◽  
Highly Efficient ◽  
Indole Synthesis

Stereocontrolled total synthesis of (+)-vinblastine (1) has been achieved using a novel radical-mediated indole synthesis developed in our laboratories. The isothiocyanate 18, prepared readily from quinoline 17, underwent a facile addition of the malonate anion to give 19. The o-alkenylthioanilide 19 was then converted to indole 20 by radical cyclization and protection. (−)-Vindoline (2) was prepared from this key intermediate 20 in a highly efficient manner. The indole core of the 11-membered intermediate 3 was constructed similarly from quinoline. The critical coupling reaction between 2 and the chloroindolenine derived from 3 proceeded with complete control of stereochemistry to give the desired product 66 in 97 % yield, which could be successfully converted to (+)-vinblastine (1).

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