ChemInform Abstract: Discovery of GSK143 (I), a Highly Potent, Selective and Orally Efficacious Spleen Tyrosine Kinase Inhibitor.

Kinase Inhibitor ◽

Faculty Opinions recommendation of A spleen tyrosine kinase inhibitor reduces the severity of established glomerulonephritis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.2269956.1889054 ◽

2010 ◽

Author(s):

Jurg Schifferli ◽

Michael Mayr

Keyword(s):

Tyrosine Kinase ◽

Kinase Inhibitor ◽

The Orally Available Spleen Tyrosine Kinase Inhibitor 2-[7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide Dihydrochloride (BAY 61-3606) Blocks Antigen-Induced Airway Inflammation in Rodents

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.103.052316 ◽

2003 ◽

Vol 306 (3) ◽

pp. 1174-1181 ◽

Cited By ~ 135

Author(s):

Noriyuki Yamamoto ◽

Keisuke Takeshita ◽

Michitaka Shichijo ◽

Toshio Kokubo ◽

Masako Sato ◽

...

Keyword(s):

Tyrosine Kinase ◽

Airway Inflammation ◽

Kinase Inhibitor ◽

The Spleen Tyrosine Kinase (Syk) in Human Disease, Implications for Design of Tyrosine Kinase Inhibitor Based Therapy

Current Pharmaceutical Design ◽

10.2174/1381612043384493 ◽

2004 ◽

Vol 10 (15) ◽

pp. 1739-1744 ◽

Cited By ~ 14

Author(s):

Christopher Navara

Keyword(s):

Tyrosine Kinase ◽

Human Disease ◽

Kinase Inhibitor ◽

BI 1002494, a Novel Potent and Selective Oral Spleen Tyrosine Kinase Inhibitor, Displays Differential Potency in Human Basophils and B Cells

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.116.233155 ◽

2016 ◽

Vol 357 (3) ◽

pp. 554-561 ◽

Cited By ~ 8

Author(s):

D. J. Lamb ◽

S. L. Wollin ◽

A. Schnapp ◽

D. Bischoff ◽

K. J. Erb ◽

...

Keyword(s):

B Cells ◽

Tyrosine Kinase ◽

Kinase Inhibitor ◽

Spleen Tyrosine Kinase ◽

Human Basophils

The effect of spleen tyrosine kinase inhibitor R406 on diabetic retinopathy in experimental diabetic rats

International Ophthalmology ◽

10.1007/s10792-020-01422-4 ◽

2020 ◽

Vol 40 (9) ◽

pp. 2371-2383

Author(s):

Xian Su ◽

Zhao-Hui Sun ◽

Qian Ren ◽

Jun-Ru Liu ◽

Li Yin ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Tyrosine Kinase ◽

Kinase Inhibitor ◽

Diabetic Rats ◽

In silico Spleen Tyrosine Kinase Inhibitor Screening by ChooseLD

IPSJ Transactions on Bioinformatics ◽

10.2197/ipsjtbio.8.14 ◽

2015 ◽

Vol 8 (0) ◽

pp. 14-20

Author(s):

Hideaki Umeyama ◽

Mitsuo Iwadate ◽

Y-h. Taguchi

Keyword(s):

Tyrosine Kinase ◽

In Silico ◽

Kinase Inhibitor ◽

Spleen Tyrosine Kinase ◽

Inhibitor Screening

GSK2646264, a spleen tyrosine kinase inhibitor, attenuates the release of histamine in ex vivo human skin

British Journal of Pharmacology ◽

10.1111/bph.14610 ◽

2019 ◽

Vol 176 (8) ◽

pp. 1135-1142 ◽

Cited By ~ 6

Author(s):

Cesar Ramirez Molina ◽

Sidsel Falkencrone ◽

Per S. Skov ◽

Edward Hooper‐Greenhill ◽

Mike Barker ◽

...

Keyword(s):

Tyrosine Kinase ◽

Human Skin ◽

Kinase Inhibitor ◽

Ex Vivo ◽

Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis

Pharmacology Research & Perspectives ◽

10.1002/prp2.16 ◽

2013 ◽

Vol 1 (2) ◽

Cited By ~ 4

Author(s):

Greg Coffey ◽

Andreas Betz ◽

Jonathan Graf ◽

Gillian Stephens ◽

Pei Hua Lin ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

B Cells ◽

Tyrosine Kinase ◽

Peripheral Blood ◽

Kinase Inhibitor ◽

Correction to “R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation”

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.112.05er13 ◽

2013 ◽

Vol 345 (2) ◽

pp. 326-326 ◽

Cited By ~ 1

Keyword(s):

Tyrosine Kinase ◽

Immune Complex ◽

Kinase Inhibitor ◽

Fc Receptor ◽

Receptor Signaling ◽

Effects of Fostamatinib, an Oral Spleen Tyrosine Kinase Inhibitor, in Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate: Results From a Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study

Arthritis & Rheumatology ◽

10.1002/art.38851 ◽

2014 ◽

Vol 66 (12) ◽

pp. 3255-3264 ◽

Cited By ~ 66

Author(s):

Michael E. Weinblatt ◽

Mark C. Genovese ◽

Meilien Ho ◽

Sally Hollis ◽

Krystyna Rosiak-Jedrychowicz ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Tyrosine Kinase ◽

Kinase Inhibitor ◽

Phase Iii ◽

Inadequate Response ◽

Spleen Tyrosine Kinase ◽

Double Blind ◽

Double Blind Placebo ◽

Parallel Group